[Printing Process Quality Control of Bioprinting Medical Devices].

Objective: This study analyzes the risk points in the quality control of bioink and the main processes of bioprinting, clarifies and explores the quality control and supervision model for bioprinting medical devices, and provides theoretical and practical guidance to ensure the safety and effectiveness of bioprinting medical devices.

Methods: The quality control risk points throughout the bioprinting process were comprehensively analyzed, with a particular focus on bioprinting materials and key processes. The regulatory model and methods for bioprinting medical devices were examined.

Three-dimensional bioprinted BMSCs-laden highly adhesive artificial periosteum containing gelatin-dopamine and graphene oxide nanosheets promoting bone defect repair.

The periosteum is a connective tissue membrane adhering to the surface of bone tissue that primarily provides nutrients and regulates osteogenesis during bone development and injury healing. However, building an artificial periosteum with good adhesion properties and satisfactory osteogenesis for bone defect repair remains a challenge, especially using three-dimensional (3D) bioprinting. In this study, dopamine was first grafted onto the molecular chain of gelatin using-(3-dimethylaminopropyl)-'-ethylcarbodiimide hydrochloride and-hydroxysuccinimide (NHS) to activate the carboxyl group and produce modified gelatin-dopamine (GelDA).

Study on Chinese Farmland Ecosystem Service Value Transfer Based on Meta Analysis.

An analytic database was built based on meta-regression analysis (MRA) method, mainly including ecosystem service type, farmland division, cultivated land type, value assessment method, and farmland characteristics. The feasible weighted least square (FWLS) method was adopted to comprehensively investigate the seventy observations from empirical studies. The results indicate that: (1) except the negative impact of farmland area on farmland value, such factors as paddy field, good soil conservation function, mainly providing agricultural products, and using market value method for assessment all produce positive effect on the promotion of farmland value.

Research Progress of Robot Technology in 3D Bioprinting.

Three-dimensional (3D) bioprinting is an emerging research direction in bio-manufacturing, a landmark in the shift from traditional manufacturing to high-end manufacturing. It integrates manufacturing science, biomedicine, information technology, and material science. bioprinting is a type of 3D bioprinting which aims to print tissues or organs directly on defective sites in the human body.

A Nanozyme-Immobilized Hydrogel with Endogenous ROS-Scavenging and Oxygen Generation Abilities for Significantly Promoting Oxidative Diabetic Wound Healing.

Non-healing wound is a common complication of diabetic patients associated with high morbidity and mortality. Engineered therapeutic hydrogels have enviable advantages in tissue regeneration, however, they are suboptimal for the healing of diabetic wounds characterized by reactive oxygen species (ROS) accumulation and chronic hypoxia. Here, a unique biological metabolism-inspired hydrogel, for ameliorating this hostile diabetic microenvironment, is presented.

[Analysis of Technical Evaluation for Current Regulation of 3D Printed Customized Medical Device].

This paper summarizes the current research status of 3D printed customized medical devices regulations in US and EU. Based on the discussion of 3D printed customized medical devices in the US and the European Union, some thoughts are put forward from design, manufacturing, testing and other aspects.

Hybridization oscillation in the one-dimensional Kondo-Heisenberg model with Kondo holes.

We use the density matrix renormalization group method to study the properties of the one-dimensional Kondo-Heisenberg model doped with Kondo holes. We find that the perturbation of the Kondo holes to the local hybridization exhibits spatial oscillation pattern and its amplitude decays exponentially with distance away from the Kondo hole sites. The hybridization oscillation is correlated with both the charge density oscillation of the conduction electrons and the oscillation in the correlation function of the Heisenberg spins.