Publications by authors named "Xie Jin"

,-Dimethylformamide (DMF) is a widely used solvent, and its green and low-carbon synthesis methods are in high demand. Herein, we report a new approach for DMF synthesis using a continuous flow reaction system with a fixed-bed reactor and a ZnO-TiO solid solution catalyst. This catalyst effectively utilizes CO, H, and dimethylamine (DMA) as feedstocks, demonstrating performance with 99% DMF selectivity and single-pass DMA conversion approaching thermodynamic equilibrium.

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Tuberculosis (TB), caused by (), remains a major global health challenge, primarily due to the increasing prevalence of drug resistance. Consequently, the development of drugs with novel modes of action (MOAs) is urgently required. In this study, we discovered and characterized two potent inhibitors, Pi-1-58 and Pi-2-26, targeting the prokaryotic ubiquitin-like protein (Pup) ligase PafA of .

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ATP (adenosine triphosphate) and HMGB1 (high mobility group box 1 protein) are key players in treatments that induce immunogenic cell death (ICD). However, conventional therapies, including radiotherapy, are often insufficient to induce ICD. In this study, we explore a strategy using nanoparticle-loaded macrophages as a source of ATP and HMGB1 to complement radiation-induced intrinsic and adaptive immune responses.

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Calcium signaling plays a crucial role in the activation of T lymphocytes. However, modulating calcium levels to control T cell activation in vivo remains a challenge. In this study, we investigate T cell activation using 12-myristate 13-acetate (PMA)-encapsulated CaCO nanoparticles.

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This study introduces a novel approach of precisely depositing InO nanoislands on the edges of BN sheets using selective atomic layer deposition. The modified catalysts demonstrated a significant improvement and characterization results revealed that the presence of InO nanoislands, when free of BO overlayers, is crucial in mitigating side reactions.

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Vapor phase infiltration (VPI) facilitates the incorporation of inorganic components into organic polymers, emerging as an effective technique for fabricating organic-inorganic hybrid materials. However, the complexity of diffusion behavior during the VPI process presents challenges in studying diffusion kinetics, particularly for highly reactive precursor-polymer systems such as trimethylaluminum (TMA) and poly(ethylene oxide) (PEO). In this study, we investigate the VPI process of TMA in PEO using in situ quartz crystal microgravimetry (QCM), which enables measurement of diffusion behavior and kinetics with high precision due to its high temporal resolution.

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Background: Hypotension after induction of general anesthesia may lead to severe complications in elderly patients. This study investigated whether the respiratory variation of velocity time integral (ΔVTI) and peak velocity (ΔVpeak) of left ventricular outflow tract (LVOT) could predict hypotension after induction of general anesthesia in elderly patients.

Methods: 120 elderly patients undergoing selective operation under general anesthesia were enrolled in this study.

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This study investigated the macro & micro properties of the composite gels formed by soy protein isolate (SPI) and peach pectin fractions: water-soluble pectin (WSP), chelator-soluble pectin (CSP), and sodium carbonate soluble pectin (NSP). Specially, the interaction between pectin fractions and SPI was studied to explain the formation mechanism of the composite gels. WSP, as a high methoxyl pectin, exhibited rich branching (sugar ratio B = 3.

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Objective: To explore the changes of Pigment Epithelium-Derived Factor (PEDF), Matrix Metalloproteinase-2 (MMP-2), and Transforming Growth Factor-β2 (TGF-β2) levels in the aqueous humor of cataract patients and their correlation with disease severity.

Methods: 93 cataract patients and 56 healthy subjects were study objects. PEDF, MMP-2, and TGF-β2 levels of aqueous humor were compared, and the correlation between each index and Lens Opacity Classification System (LOCS) III classification was analyzed.

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ConspectusAlkenes and alkynes are fundamental building blocks in organic synthesis due to their commercial availability, bench-stability, and easy preparation. Selective functionalization of alkenes and alkynes is a crucial step for the synthesis of value-added compounds. Precise control over these reactions allows efficient construction of complex molecules with new functionalities.

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Developing an efficient strategy to replace the conventional synthesis method for producing isoindolinone (IIO) scaffold, a crucial structural motif for constructing pharmaceutical molecules, remains to be a great challenge. Herein, a single-atom Pd/TiO tandem catalysis has been developed for the IIO scaffold synthesis by using readily available phthalic anhydride (PA), ammonia, and H. The single-atom Pd/TiO catalyst demonstrates superior catalytic performance, achieving a PA conversion of 99 %, an IIO selectivity of 91 %, and a turnover frequency (TOF) up to 4807 h.

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Ethnopharmacological Relevance: Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by non-specific inflammation. Managing UC presents significant challenges due to its chronic nature and high recurrence rates. Indigo naturalis has emerged as a potential therapeutic agent in clinical UC treatment, demonstrating advantages in alleviating refractory UC and maintaining remission periods compared to other therapeutic approaches.

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Ulcerative colitis (UC) poses a threat to human health. The present study attempts to unravel the efficacy and potential mechanisms of paeoniflorin (PF), a naturally sourced active ingredient, for the management of UC. By establishing a DSS (dextran sulphate sodium)-induced experimental rat model of UC, this study found that PF was effective in ameliorating UC symptoms, inhibiting oxidative stress, inflammation and apoptosis, and repairing colonic epithelial damage.

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A shock-tube facility capable of generating a planar shock with the Mach number higher than 3.0 is developed for studying Richtmyer-Meshkov instability induced by a strong shock wave (referred to as strong-shock RMI). Shock enhancement is realized through the convergence of shock within a channel with the profile determined by using shock dynamics theory.

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Article Synopsis
  • - The research addresses the challenge of low optical nonlinearity in silica-based photonic crystal fibers (PCFs) that limits supercontinuum generation (SCG) efficiency and explores a new method using solid-state 2D MoS atomic layers embedded in PCF air-holes to enhance this process.
  • - The results show a 4.8 times increase in the nonlinear coefficient and a 70% decrease in the power threshold for SCG in the MoS-PCF hybrid, which can produce light spanning an octave.
  • - It was observed that the enhancement of SCG is dependent on the number of MoS layers, with optimal results occurring at a thickness of five atomic layers, highlighting the importance of carefully selecting layer
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Reliable and precise straightness profile measurements are crucial for manufacturing ultra-precision components and are capable of further enhancing their accuracy. The Fourier three-probe (F3P) straightness measurement allows for precise assessment of the workpiece profile on the machine by eliminating the harmful influence of the error motion of the sliding table. However, the probe spacing uncertainty deteriorates the measurement accuracy remarkably; and, the affecting mechanism behind this phenomenon has not yet been studied in detail.

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Excitation of multiple acoustic wave modes on a single chip is beneficial to implement diversified acoustofluidic functions. Conventional acoustic wave devices made of bulk LiNbO substrates generally generate few acoustic wave modes once the crystal-cut and electrode pattern are defined, limiting the realization of acoustofluidic diversity. In this paper, we demonstrated diversity of acoustofluidic behaviors using multiple modes of acoustic waves generated on piezoelectric-thin-film-coated aluminum sheets.

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Selective activation of the benzylic C(sp)-H bond is pivotal for the construction of complex organic frameworks. Achieving precise selectivity among C-H bonds with comparable energetic and steric profiles remains a profound synthetic challenge. Herein, we unveil a site- and stereoselective benzylic C(sp)-H alkenylation utilizing metallaphotoredox catalysis.

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We synthesized MgO NPs via sol-gel reaction and investigated them as carriers to deliver Mg to the affected joint for osteoarthritis (OA). The physicochemical properties of samples were characterized by transmission electron microscope (TEM), dynamic light scattering (DLS) and x-ray diffraction (XRD). The release of Mg was monitored by ICP-MS.

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Multi-modal 3D object detection is instrumental in identifying and localizing objects within 3D space. It combines RGB images from cameras and point-clouds data from lidar sensors, serving as a fundamental technology for autonomous driving applications. Current methods commonly employ simplistic element-wise additions or multiplications to aggregate multi-modal features extracted from point-clouds and images.

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In multistate non-Hermitian systems, higher-order exceptional points and exotic phenomena with no analogues in two-level systems arise. A paradigm is the exceptional nexus (EX), a third-order EP as the cusp singularity of exceptional arcs (EAs), that has a hybrid topological nature. Using atomic Bose-Einstein condensates to implement a dissipative three-state system, we experimentally realize an EX within a two-parameter space, despite the absence of symmetry.

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Article Synopsis
  • The study aimed to evaluate how changes in alpha-fetoprotein (AFP) levels can predict outcomes in patients with unresectable hepatocellular carcinoma (u-HCC) treated with a combination of therapies, including hepatic artery infusion chemotherapy (HAIC), lenvatinib, and camrelizumab.
  • Researchers analyzed 63 patients, finding that those who showed a significant early decrease in AFP levels had better overall survival (OS) and progression-free survival (PFS) compared to those who didn’t.
  • The findings suggest that monitoring AFP responses can serve as important biomarkers for determining the effectiveness of these treatments in u-HCC patients.
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Hemicellulose is one of the most important natural polysaccharides in nature. Hemicellulose from different sources varies in chemical composition and structure, which in turn affects the modification effects and industrial applications. Grain and oil by-products (GOBPs) are important raw materials for hemicellulose.

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Intermittent hydroxylamine (NHOH) dosing strategy was applied to enhance the stability of partial nitrification and total nitrogen (N) removal efficiency (TNRE) in a continuous-flow process. The results showed 2 mg/L of NHOH dosing (once every 6 h) could maintain stably partial nitrification with nitrite accumulation rate (NAR) of 91.6 % and TNRE of 92.

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Background: Cataract contributes to visual impairment worldwide, and diabetes mellitus accelerates the formation and progression of cataract. Here we found that the expression level of miR-204-5p was diminished in the lens epithelium with anterior lens capsule of cataract patients compared to normal donors, and decreased more obviously in those of diabetic cataract (DC) patients. However, the contribution and mechanism of miR-204-5p during DC development remain elusive.

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