Family Physicians' Use of, Barriers to, and Attitudes Toward Remote Diagnosis and Treatment in China: A National Web-Based Survey.

China has introduced a series of policies to encourage family physicians (FPs) to provide remote diagnosis and treatment (RDT) services, with the ultimate goal of providing more continuous, convenient, and efficient medical services for all residents, especially elderly patients and patients with chronic diseases. However, few studies have focused on this important issue. The aim of this study was to provide a comprehensive description of FPs' use of, barriers to, and attitudes toward RDT in China.

Enhancing assistive technology design: Biomechanical finite element modeling for grasping strategy optimization in exoskeleton data gloves.

This paper endeavors to enhance the control mechanisms governing the grasping strategy of exoskeleton data gloves. A comprehensive approach was devised, integrating finite element numerical simulation techniques with the computerized control system of exoskeleton data gloves, establishing a novel, precise, and three-dimensional biomechanical finite element model of the hand. By amalgamating finite element modeling technology, biomechanical understanding, and hand kinematics, a straightforward yet efficient virtual grasping methodology was introduced to replicate three typical grasping actions dynamically.

Fine-scale patterns of SARS-CoV-2 spread from identical pathogen sequences.

Pathogen genomics can provide insights into underlying infectious disease transmission patterns, but new methods are needed to handle modern large-scale pathogen genome datasets and realize this full potential. In particular, genetically proximal viruses should be highly informative about transmission events as genetic proximity indicates epidemiological linkage. Here we use pairs of identical sequences to characterize fine-scale transmission patterns using 114,298 SARS-CoV-2 genomes collected through Washington State (USA) genomic sentinel surveillance with associated age and residence location information between March 2021 and December 2022.

MaCon: A Generic Self-Supervised Framework for Unsupervised Multimodal Change Detection.

Change detection(CD) is important for Earth observation, emergency response and time-series understanding. Recently, data availability in various modalities has increased rapidly, and multimodal change detection (MCD) is gaining prominence. Given the scarcity of datasets and labels for MCD, unsupervised approaches are more practical for MCD.

VAT: Visibility Aware Transformer for Fine-Grained Clothed Human Reconstruction.

In order to reconstruct 3D clothed human with accurate fine-grained details from sparse views, we propose a deep cooperating two-level global to fine-grained reconstruction framework that constructs robust global geometry to guide fine-grained geometry learning. The core of the framework is a novel visibility aware Transformer VAT, which bridges the two-level reconstruction architecture by connecting its global encoder and fine-grained decoder with two pixel-aligned implicit functions, respectively. The global encoder fuses semantic features of multiple views to integrate global geometric features.

Predicting PTSD development with early post-trauma assessments: a proof-of-concept for a concise tree-based classification method.

Approximately 70% of individuals globally experience at least one traumatic event in their lifetimes, potentially leading to posttraumatic stress disorder (PTSD). Understanding the development of PTSD and devising effective prevention and treatment strategies are crucial. This proof-of-concept study aimed to design a concise tree-based adaptive test using the Classification and Regression Trees (CART) framework to predict PTSD development.

Responsive Zwitterionic Materials for Enhanced Drug Delivery.

Zwitterionic materials have traditionally been recognized as exceptional antifouling agents, imparting nanocarriers with extended circulation times . Despite much studies on antifouling ability, the responsive zwitterionic materials that change physicochemical properties stimulated by mild signals are much less explored. As is known, there are multiple biological barriers in antitumor drug delivery, including the blood circulation barrier, non-specific organ distribution, elevated tumor interstitial pressure, tumor cytomembrane barrier, and lysosomal barrier.

Discovery and Verification of Soybean Sprouting Selection Based on Quality Across Various Origins and Varieties: Varietal Effects on Sprouted Soybean Quality.

Research on soybean nutrition is crucial for Chinese agriculture and public health, as soybean sprouting enhances its nutritional value. However, the relationships between grain quality and soybean varieties are not yet fully understood. In this study, the quality of 49 soybean cultivars from 15 different origins was evaluated through multiple correlation analysis.

Organ-specific immune-related adverse events and prognosis in cancer patients receiving immune checkpoint inhibitors.

Background: Patients who developed immune-related adverse events (irAEs) could benefit more from treatment with immune checkpoint inhibitors (ICIs) than those who did not develop irAEs. This study was designed to assess whether the occurrence of irAEs or their characteristics are correlated with survival in advanced patients treated with ICIs.

Methods: This retrospective cohort study enrolled a panel of cancer patients who received ICIs at a single institute.

A first-in-human study of JNJ-70218902, a bispecific T-cell-redirecting antibody against TMEFF2 in metastatic castration-resistant prostate cancer.

Background: Metastatic castration-resistant prostate cancer (mCRPC) has a poor prognosis, necessitating the investigation of novel treatments and targets. This study evaluated JNJ-70218902 (JNJ-902), a T-cell redirector targeting transmembrane protein with epidermal growth factor-like and 2 follistatin-like domains 2 (TMEFF2) and cluster of differentiation 3, in mCRPC.

Patients And Methods: Patients who had measurable/evaluable mCRPC after at least one novel androgen receptor-targeted therapy or chemotherapy were eligible.

LPS-induced TMBIM6 splicing drives endothelial necroptosis and aggravates ALI.

Background: The mechanism underlying necroptosis in pulmonary vessel endothelial cells (PVECs) resulting from long non-coding RNA (lncRNA)-induced alternative splicing (AS) of target genes in acute lung injury (ALI) remains unclear.

Methods: Lipopolysaccharide (LPS)-induced expression of tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6, and lncRNAs was analyzed via RT-PCR in PVECs. Full-transcriptome sequencing was used to detect AS-related mRNAs.

Dissociated response and treatment outcome with immune checkpoint blockade in advanced cancer.

Immune-related dissociated response (DR) has been recently recognized and have become a subject of ongoing interest. The purpose of the present study was to evaluate the frequency, treatment outcome, and predictors of DR in cancer patients with immune checkpoint inhibitors. We retrospectively collected clinicopathological data from a cohort of patients with cancer who received PD-1/PD-L1 inhibitor-based monotherapy or combination therapy at a single institution (developing cohort).

The catch-up growth follow-up management system use and need for the parents of premature infants after discharge based on a WeChat mini program: A cross-sectional survey in China.

Preterm birth is a significant public health concern. To achieve a growth trajectory consistent with the genetic law, a catch-up growth strategy must be adopted for these infants to achieve normal growth and development. The aim of this study is to investigate the use requirements of a WeChat mini program-based post-discharge catch-up growth follow-up management system for the parents of preterm infants.

A Prediction Model for Postoperative Nausea and Vomiting After Laparoscopic Surgery for Gynecologic Cancers.

Background: Postoperative nausea and vomiting (PONV) is among the most common adverse events, accompanied with impaired prognosis. This study aimed to investigate independent predictors for PONV after laparoscopic surgery for gynecologic cancers and identify a nomogram model.

Methods: Elderly patients who underwent laparoscopic surgery for gynecologic cancers between 2021 and 2024 were retrospectively enrolled.

Rectified activity-dependent population plasticity implicates cortical adaptation for memory and cognitive functions.

Cortical network undergoes rewiring everyday due to learning and memory events. To investigate the trends of population adaptation in neocortex overtime, we record cellular activity of large-scale cortical populations in response to neutral environments and conditioned contexts and identify a general intrinsic cortical adaptation mechanism, naming rectified activity-dependent population plasticity (RAPP). Comparing each adjacent day, the previously activated neurons reduce activity, but remain with residual potentiation, and increase population variability in proportion to their activity during previous recall trials.

Association between dietary antioxidant levels and diabetes: a cross-sectional study.

Background: The onset and progression of diabetes mellitus (DM) is strongly linked to oxidative stress. Previous studies have highlighted the protective effects of individual dietary antioxidants against diabetes. However, the relationship between a comprehensive combination of dietary antioxidants and diabetes has rarely been examined.

Clinical and Genomic Epidemiology of Coxsackievirus A21 and Enterovirus D68 in Homeless Shelters, King County, Washington, USA, 2019-2021.

Congregate homeless shelters are disproportionately affected by infectious disease outbreaks. We describe enterovirus epidemiology across 23 adult and family shelters in King County, Washington, USA, during October 2019-May 2021, by using repeated cross-sectional respiratory illness and environmental surveillance and viral genome sequencing. Among 3,281 participants >3 months of age, we identified coxsackievirus A21 (CVA21) in 39 adult residents (3.

Nebulized Dexmedetomidine Alleviates Oxidative Stress in Ventilator-induced Lung Injury via Keap1-Nrf2-ARE Pathway.

This study aimed to explore the underlying mechanism of nebulized dexmedetomidine (DEX) in ameliorating ventilator-induced lung injury (VILI)-induced oxidative stress in rats. Forty 7 to 8-week-old Sprague-Dawley rats at the specific pathogen-free level were randomized into the control group, model group, nebulized dexmedetomidine (WH-YM) group, and dexmedetomidine intravenous infusion (JM-YM) group, each containing 10 rats. Except for the control group, rats in the other groups underwent mechanical ventilation (tidal volume,  40 mL/kg; respiratory rate, 70 breaths per minute; inspiratory-to-expiratory ratio, 1:2; fraction of inspired oxygen, 21%; positive end-expiratory pressure, 0 cmH2O).

Clinical application values of a novel synthetic training simulator for bulbar urethral anastomosis.

Purpose: This study aimed to report a newly developed, high-fidelity synthetic simulator to simulate excision and primary anastomotic (EPA) bulbar urethroplasty and its clinical use for new practitioners in shortening the learning curve.

Material And Methods: The bulbar urethral anastomosis simulator consists of several standardized components created according to the actual size of the male patient. Interns, novice residents, and fellows inexperienced with urethral reconstruction ( = 10, 5, 5) from different medical centres were invited to participate in the training programme.

Minimizing Survey Questions for PTSD Prediction Following Acute Trauma.

Traumatic experiences have the potential to give rise to post-traumatic stress disorder (PTSD), a debilitating psychiatric condition associated with impairments in both social and occupational functioning. There has been great interest in utilizing machine learning approaches to predict the development of PTSD in trauma patients from clinician assessment or survey-based psychological assessments. However, these assessments require a large number of questions, which is time consuming and not easy to administer.

Association between processed red meat intake and cardiovascular risk factors in patients with type 2 diabetes: a cross-sectional study from China.

Aim: To explore the association between Processed red meat (PRM) consumption and cardiovascular risk factors in Chinese adults with type 2 diabetes mellitus (T2DM).

Methods: Dietary survey, physical measurement, and blood biochemical examination were conducted on 316 patients with type 2 diabetes in Bengbu, China from May to July 2019. Possible confounding factors were identified by comparing between-group variability in the baseline table.

APOE gene polymorphism in ischemic stroke patients from Huizhou and its correlation with blood lipids and homocysteine.

Objectives: To investigate the correlation between apolipoprotein E (APOE) gene polymorphisms and ischemic stroke and its relationship with blood lipids and homocysteine (HCY) level in Huizhou City.

Materials And Methods: In this analytical cross-sectional study, we selected 2612 patients who underwent APOE genotyping from November 2019 to November 2021 at the Third People's Hospital of Huizhou. Among them, 2014 were ischemic stroke patients and 598 were non-stroke patients.

A high-throughput, polymerase-targeted RT-PCR for broad detection of mammalian filoviruses.

Filoviruses are some of the most lethal viruses in the modern world, and increasing numbers of filovirus species and genera have been discovered in recent years. Despite the potential severity of filovirus outbreaks in the human population, comparably few sensitive pan-filovirus RT-PCR assays have been described that might facilitate early detection and prevention. Here, we present a new pan-filovirus RT-PCR assay targeting the L polymerase gene for detection of all known mammalian filoviruses.

Case report: Pulmonary sarcomatoid carcinoma demonstrating rapid growth on follow-up CT.

Background: The tumor growth rate and tumor volume doubling time are crucial parameters in diagnosing and managing lung lesions. Pulmonary sarcomatoid carcinoma (PSC) is a unique and highly malignant subtype of lung cancer, with limited documentation on its growth feature. This article aims to address the gap in knowledge regarding a PSC's growth patterns by describing the characteristics of a confirmed case using computed tomography, thereby enhancing the understanding of this rare disease.