Cerebral ischemia-reperfusion injury produces excessive reactive oxygen and nitrogen species, including superoxide, nitric oxide, and peroxynitrite (ONOO). We recently developed a new ONOO-triggered metal-free carbon monoxide donor (PCOD585), exhibiting a notable neuroprotective outcome on the rat middle cerebral artery occlusion model and rendering an exciting intervention opportunity toward ischemia-induced brain injuries. However, its therapeutic mechanism still needs to be addressed.
View Article and Find Full Text PDFMyocardial ischemia-reperfusion (MI/R) injury is common in patients who undergo revascularization therapy for myocardial infarction, often leading to cardiac dysfunction. Carbon monoxide (CO) has emerged as a therapeutic molecule due to its beneficial properties such as anti-inflammatory, anti-apoptotic, and mitochondrial biogenesis-promoting properties. However, its clinical application is limited due to uncontrolled release, potential toxicity, and poor targeting efficiency.
View Article and Find Full Text PDFAfter numerous efforts to elucidate the biological role of nitric oxide (NO), NO treatments have become a hotspot at the forefront of medicine. NO-releasing substances are constantly needed, while the direct use of NO gas is unattainable in bio-systems. An ideal NO donor should possess controllable and visible NO-release capability.
View Article and Find Full Text PDFIschemia-reperfusion (I/R) injuries are from the secondary radicals of ONOO. Direct radical scavenging is difficult because of their high reactivity. ONOO is longer-lived than the radicals in the biological milieu.
View Article and Find Full Text PDFAn intersystem crossing (ISC) rate constant of 1.0×10 s was previously registered with a spiro-bis-benzophenone scaffold. Triplet generation efficiency could be further enhanced by stabilizing the spiro-charge-transfer (CT) state and rationally designing spiro-compounds (SCTs) that consist of electron-rich diphenyl ether as the spiro-CT donor and electron-deficient dinaphthyl ketone as the spiro-CT acceptor.
View Article and Find Full Text PDFFree Radic Biol Med
February 2021
Nitric oxide donors (NODs) are indispensable in biological research and disease treatment. NODs had been utilized to treat cardiovascular diseases in clinic and many others are under trial. Thiols are typically required for these donors to release NO.
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