On-Chip DNA Assembly via Dielectrophoresis.

On-chip gene synthesis has the potential to improve the synthesis throughput and reduce the cost exponentially. While there exist several microarray-based oligo synthesis technologies, on-chip gene assembly has yet to be demonstrated. This work introduces a novel on-chip DNA assembly method via dielectrophoresis (DEP) that can potentially be integrated with microarray-based oligo synthesis on the same chip.

EWOD Chip with Micro-Barrier Electrode for Simultaneous Enhanced Mixing during Transportation.

Digital microfluidic platforms have been extensively studied in biology. However, achieving efficient mixing of macromolecules in microscale, low Reynolds number fluids remains a major challenge. To address this challenge, this study presents a novel design solution based on dielectric electro-wetting (EWOD) by optimizing the geometry of the transport electrode.

Applications of electrowetting-on-dielectric (EWOD) technology for droplet digital PCR.

Digital microfluidics is an elegant technique based on single droplets for the design, composition, and manipulation of microfluidic systems. In digital microfluidics, especially in the electrowetting on dielectric (EWOD) system, each droplet acts as an independent reactor, which enables a wide range of multiple parallel biological and chemical reactions at the microscale. EWOD digital microfluidics reduces reagent and energy consumption, accelerates analysis, enables point-of-care diagnostic, simplifies integration with sensors, etc.

The In Situ Sulfidation of Cu O by Endogenous H S for Colon Cancer Theranostics.

Expression of a high concentration of H S is closely related to the formation of colon cancer tumors. However, only a few H S-triggered theranostics agents for colon cancer have been reported to date. Now, a turn-on theranostics agent was developed by utilizing the in situ reaction of Cu O and endogenous H S at colon tumor sites.