Population Pharmacokinetic-Pharmacodynamic Modeling of Granulocyte Colony-Stimulating Factor to Optimize Dosing and Timing for CD34 Cell Harvesting.

Granulocyte colony-stimulating factor (G-CSF) mobilizes peripheral blood (PB) progenitor cells from bone marrow (BM) into circulation for PB stem cell transplantation (PBSCT). This study aimed to develop a population pharmacokinetic-pharmacodynamic (PK-PD) model of filgrastim in healthy subjects to optimize PB CD34 cell collection. Plasma filgrastim concentrations and CD34 cell count data were obtained from a clinical study involving healthy Korean subjects.

Relationship between dietary fiber physicochemical properties and feedstuff fermentation characteristics and their effects on nutrient utilization, energy metabolism, and gut microbiota in growing pigs.

Background: There is a growing focus on using various plant-derived agricultural by-products to increase the benefits of pig farming, but these feedstuffs are fibrous in nature. This study investigated the relationship between dietary fiber physicochemical properties and feedstuff fermentation characteristics and their effects on nutrient utilization, energy metabolism, and gut microbiota in growing pigs.

Methods: Thirty-six growing barrows (47.

Gastric cancer-derived exosomal let-7 g-5p mediated by SERPINE1 promotes macrophage M2 polarization and gastric cancer progression.

Background: Tumor-associated macrophages (TAMs), particularly M2-polarized TAMs, are significant contributors to tumor progression, immune evasion, and therapy resistance in gastric cancer (GC). Despite efforts to target TAM recruitment or depletion, clinical efficacy remains limited. Consequently, the identification of targets that specifically inhibit or reprogram M2-polarized TAMs presents a promising therapeutic strategy.

Comparative diagnostic performance of imaging modalities in chronic pancreatitis: a systematic review and Bayesian network meta-analysis.

Purpose: We aimed to perform a Bayesian network meta-analysis to assess the comparative diagnostic performance of different imaging modalities in chronic pancreatitis(CP).

Methods: The PubMed, Embase and Cochrane Library databases were searched for relevant publications until March 2024. All studies evaluating the head-to-head diagnostic performance of imaging modalities in CP were included.

Integrating Plasma Metabolomics, Network Pharmacology, and Experimental Validation to Investigate the Action Mechanism of Qiangxin Lishui Prescription in Chronic Heart Failure.

The high mortality rate of chronic heart failure (CHF) makes it a primary battlefield in the field of cardiovascular diseases. Qiangxin Lishui Prescription (QLP) is a traditional Chinese medicine (TCM) prescription used clinically for treating CHF, but its underlying mechanism remains unclear. This study integrated plasma metabolomics, network pharmacology, and experimental validation to reveal the pharmacological effects of QLP and its potential mechanism of anti-CHF.

Titin gene mutations enhance radiotherapy efficacy via modulation of tumour immune microenvironment in rectum adenocarcinoma.

Objective: This study investigates the impact of Titin (TTN) gene mutations on radiotherapy sensitivity in rectum adenocarcinoma (READ) by examining changes in the tumour immune microenvironment.

Methods: Data on gene expression and mutations in READ were obtained from The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) databases. Bioinformatics analysis explored the correlation between TTN mutations and immune cell infiltration.

Exosome-derived long non-coding RNA AC010789.1 modified by FTO and hnRNPA2B1 accelerates growth of hair follicle stem cells against androgen alopecia by activating S100A8/Wnt/β-catenin signalling.

Background: The increased incidence of androgenic alopecia (AGA) causes adverse physiological and psychological effects on people of all genders. The hair follicle stem cells (HFSCs) have displayed clinical improvements on AGA. However, the molecular mechanism of HFSCs against AGA remains elusive.

[Epidemiological characteristics and related factors of multimorbidity of wasting and spinal curvature abnormalities among children and adolescents aged 6-18 years in Inner Mongolia Autonomous Region, China].

To analyze the epidemiological characteristics of wasting, spinal curvature abnormalities and multimorbidity among children and adolescents aged 6-18 in Inner Mongolia and explore the related factors of these two health problems. In September 2022, a stratified random cluster sampling method was employed to select 188 635 children and adolescents aged 6-18 in Inner Mongolia for physical examinations and questionnaire surveys. Data on height, weight, as well as dietary behavior, physical activity, classroom environment, academic tasks, writing posture, and screen behavior were collected.

First Reported Case of Hemoglobin H Disease Caused by the Rare α-Globin Gene Mutation ( c.244delT) in a Chinese Family.

Microcytosis of red cells and mild anemia are common in thalassemia carriers but those phenotypes are not specific. It is really a challenge for clinical interpretation of those variants. Co-segregation with disease in affected family members or specific phenotypes such as the abnormal Hb H are very helpful to assess the pathogenicity of rare variants.

Optimizing electrode configurations for EEG mild cognitive impairment detection.

The Optimal electrode configuration of Electroencephalograms (EEG) systems for mild cognitive impairment (MCI) detection and monitoring in non-clinical settings, i.e. number of electrodes and the positions of the electrodes, remains to be explored.

Development and characterization of a surfactant responsive to redox conditions for gas recovery in foam drainage.

To address the challenge of reusing foaming agents in foam drainage gas production processes, we developed a redox-responsive surfactant with a straightforward preparation method based on molecular electrostatic interaction assembly. The redox response mechanism of the surfactant was investigated through surface tension, absorbance, particle size, and Zeta potential analyses. Results indicate that the minimum surface tension in the oxidized state can reach 26.

Multiplexed food-borne pathogen detection using an argonaute-mediated digital sensor based on a magnetic-bead-assisted imaging transcoding system.

Accurate, sensitive and multiplexed detection of food-borne pathogens is crucial for assessing food safety risks. Here we present a digital DNA-amplification-free nucleic acid detection assay to achieve multiplexed and ultrasensitive detection of three food-borne pathogens. We used mesophilic Clostridium butyricum argonaute and magnetic beads in a digital carrier system (d-MAGIC).

A robust and interpretable ensemble machine learning model for predicting healthcare insurance fraud.

Healthcare insurance fraud imposes a significant financial burden on healthcare systems worldwide, with annual losses reaching billions of dollars. This study aims to improve fraud detection accuracy using machine learning techniques. Our approach consists of three key stages: data preprocessing, model training and integration, and result analysis with feature interpretation.

FN1 shapes the behavior of papillary thyroid carcinoma through alternative splicing of EDB region.

Papillary thyroid cancer (PTC) is often characterized by indolent behavior, small tumors with slow cell proliferation and a tendency to metastasize to cervical lymph node simultaneously, and the molecular mechanisms underlying that remain poorly understood. In this study, FN1 was the hottest gene of PTC and distinctive expression in PTC cells. FN1 deficiency severely inhibited the p53 signaling pathway, especially cyclin proteins, resulting in increased cell growth but hampered invasion.

Room-temperature creation and conversion of individual skyrmion bags in magnetic multilayered disks.

Skyrmion bags, with arbitrary topological charge Q, have recently attracted much interest, since such high-Q topological systems could open a way for topological magnetism research and are promising for spintronic applications with high flexibility for information encoding. Investigation on room-temperature skyrmion bags in magnetic multilayered structures is essential for applications and remains unexplored so far. Here, we demonstrate room-temperature creation and manipulation of individual skyrmion bags in magnetic multilayered disks.

Simulation study on catalytic oxidation of low concentration mine gas in an oxidation device.

Anthropogenic emissions of non-CO greenhouse gases, such as low-concentration coal mine methane (cCH < 30 vol%), have a significant impact on global warming. The main component of coal mine methane is methane (CH), which is both a greenhouse gas and a high-quality clean energy gas. To study the combustion and heat transfer reactions of low-concentration coal mine methane in a catalytic oxidation device, a numerical simulation approach was employed to establish a model of the catalytic oxidation device that includes periodic boundary conditions, methane combustion mechanisms, and turbulent-laminar flow characteristics.

LiZrF protective layer enabled high-voltage LiCoO positive electrode in sulfide all-solid-state batteries.

The application of high-voltage positive electrode materials in sulfide all-solid-state lithium batteries is hindered by the limited oxidation potential of sulfide-based solid-state electrolytes (SSEs). Consequently, surface coating on positive electrode materials is widely applied to alleviate detrimental interfacial reactions. However, most coating layers also react with sulfide-based SSEs, generating electronic conductors and causing gradual interface degradation and capacity fading.

Change in kidney volume growth rate and renal outcomes of tolvaptan treatment in autosomal dominant polycystic kidney disease: post-hoc analysis of TEMPO 3:4 trial.

Background: Despite of long-lasting tolvaptan treatment, individual renal outcomes are unclear in autosomal dominant polycystic kidney disease (ADPKD). This post-hoc analysis of the TEMPO 3:4 trial aimed to evaluate the predictability of estimated height-adjusted total kidney volume growth rate (eHTKV-α) on renal outcomes.

Methods: In TEMPO 3:4, 1445 patients with ADPKD were randomised to tolvaptan or placebo for 3 years.

The independent and combined associations of nocturnal sleep duration, sleep midpoint, and sleep onset latency with global cognitive function in older Chinese adults.

This study aims to investigate the independent and combined associations of nocturnal sleep duration, sleep midpoint, and sleep onset latency with global cognitive function in older Chinese adults. Our cross-sectional study included 4601 community-dwelling cognitively unimpaired adults aged 60 years or older from the West China Health and Aging Cohort Study. Sleep characteristics were assessed using the Pittsburgh Sleep Quality Index, and global cognitive function was evaluated using the Mini-Mental State Examination (MMSE).

Label credibility correction based on cell morphological differences for cervical cells classification.

Cervical cancer is one of the deadliest cancers that pose a significant threat to women's health. Early detection and treatment are commonly used methods to prevent cervical cancer. The use of pathological image analysis techniques for the automatic interpretation of cervical cells in pathological slides is a prominent area of research in the field of digital medicine.

Generative adversarial synthetic neighbors-based unsupervised anomaly detection.

Anomaly detection is crucial for the stable operation of mechanical systems, securing financial transactions, and ensuring network security, among other critical areas. Presently, Generative Adversarial Networks (GANs)-based anomaly detection methods either require labeled data for semi-supervised learning or face challenges with low computational efficiency and poor generalization when dealing with complex distributions. Aim to address these limitations, we introduce a generative adversarial synthetic neighbors-based unsupervised anomaly detection (GASN) method.

Salient object detection with non-local feature enhancement and edge reconstruction.

The salient object detection task based on deep learning has made significant advances. However, the existing methods struggle to capture long-range dependencies and edge information in complex images, which hinders precise prediction of salient objects. To this end, we propose a salient object detection method with non-local feature enhancement and edge reconstruction.

Study on the load-supporting characteristic of the new type of support disc-type anchor under cyclic loading test.

The new type of support disc-type anchor is an expanded body anchor with broad application prospects, and its load-bearing performance is significantly better than that of traditional anchors. However, there is a problem of premature shear damage in traditional support disc-type anchors. In order to solve this problem, this paper improves the traditional support disk anchor.