Integration analysis of tumor metagenome and peripheral immunity data of diffuse large-B cell lymphoma.

Background/purpose: It has been demonstrated that gut microbes are closely associated with the pathogenesis of lymphoma, but the gut microbe landscape and its association with immune cells in diffuse large B-cell lymphoma (DLBCL) remain largely unknown. In this study, we explored the associations between gut microbiota, clinical features and peripheral blood immune cell subtypes in DLBCL.

Method: A total of 87 newly diagnosed DLBCL adults were enrolled in this study.