The study of gp130/the inflammatory factors regulating osteoclast differentiation in rheumatoid arthritis.

Rheumatoid arthritis (RA) is a chronic immune disease characterized by synovitis and bone destruction. The osteoclasts play a critical role in pathologic bone loss during inflammatory arthritis. In this paper, we report that Interleukin (IL)-6, IL-6Rα/gp130, IL-11, IL-27, and Matrix Metallo Proteinases (MMP)-9 expression results in serum of the RA group were significantly higher than that of the control group.

Supramolecular trap for catching polyamines in cells as an anti-tumor strategy.

Polyamines are essential for the growth of eukaryotic cells and can be dysregulated in tumors. Here we describe a strategy to deplete polyamines through host-guest encapsulation using a peptide-pillar[5]arene conjugate (P1P5A, P1 = RGDSK(N)EEEE) as a supramolecular trap. The RGD in the peptide sequence allows the molecule to bind to integrin αβ-overexpressing tumor cells.

Terphen[n]arenes and Quaterphen[n]arenes (n=3-6): One-Pot Synthesis, Self-Assembly into Supramolecular Gels, and Iodine Capture.

Herein, two new classes of macrocyclic compounds, terphen[n]arenes (TPns) (n=3-6) and quaterphen[n]arenes (QPns) (n=3-6), were designed and synthesized by a one-step condensation reaction in relatively high yields. They comprise 2,2''-dimethoxy terphenyl and 2,2'''-dimethoxy quaterphenyl monomers, respectively, linked by methylene bridges. Given their long and rigid monomers, TPns and QPns have much larger cavities and better self-assembly properties than classic macrocycles.

Synthesis of a water-soluble 2,2'-biphen[4]arene and its efficient complexation and sensitive fluorescence enhancement towards palmatine and berberine.

A water-soluble 2,2'-biphen[4]arene (2,2'-CBP4) containing eight carboxylato moieties was synthesized and characterized. Its complexation behavior towards two alkaloids, palmatine () and berberine (), was investigated by means of fluorescence and H NMR spectroscopy in aqueous phosphate buffer solution (pH 7.4).

A pH responsive complexation-based drug delivery system for oxaliplatin.

A responsive drug delivery system (DDS) for oxaliplatin () has been designed with a view to overcoming several drawbacks associated with this anticancer agent, including fast degradation/deactivation in the blood stream, lack of tumor selectivity, and low bioavailability. The present approach is based on the direct host-guest encapsulation of by a pH-responsive receptor, carboxylatopillar[6]arene (). The binding affinities of for were found to be pH-sensitive at biologically relevant pH.

Simultaneous determination of blockers and agonists by on-fiber derivatization in self-made solid-phase microextraction coating fiber.

An environmentally friendly and sensitive method for determination of blockers and agonists was described in this paper. The method is based on a homemade sol-gel solid-phase microextraction (SPME) coating with simultaneous on-fiber derivatization and subsequent gas chromatography mass spectrometry (GC/MS) analysis. The influences of the main factors on the type and thickness of the homemade fiber coatings, conditions of the derivatization, extraction and desorption of SPME were investigated in detail.

Capillary electrokinetic fractionation mass spectrometry (CEkF/MS): technology setup and application to metabolite fractionation from complex samples coupled at-line with ultrahigh-resolution mass spectrometry.

Capillary electrokinetic fractionation (CEkF) is investigated as a new, simple, and robust approach for semipreparative and analytical sample analysis based on pKa -dependant pH-driven electrophoretic mobility. CEkF was optimized with contactless conductivity detection and conducted with 10 kV reverse voltage for 10 min, then coupled on/at-line to ESI/MS. We propose a semi-empirical model with 14 representative compounds based on the correlation between sample/medium pH regulating the partial charge, the electrokinetic loading of the capillary and intensity (I) of analytes.