Publications by authors named "Xiating Li"

Article Synopsis
  • - Coughing serves as a protective reflex to remove harmful substances from the airway, but how the brain processes this reflex isn't fully understood.
  • - Researchers created a method to quantitatively assess cough-like reflexes in mice and discovered that specific neurons in the nucleus of the solitary tract (NTS) play a critical role in these reflexes.
  • - The activation of these NTS neurons, which receive signals from vagal sensory neurons, triggers respiratory responses similar to coughing, highlighting their importance in initiating cough-like reflexes via a specific neural pathway to the cough center in the brain.
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Objective: Tea has been utilized in cancer research and is progressively gaining wider recognition, with its roles in cancer prevention and treatment being increasingly affirmed. The objective of this study is to investigate the current state and research hotspots in the field of tea's involvement in cancer research from 2013 to 2023, aiming to offer reference and direction for future studies.

Methods: We analyzed 4,789 articles published between 2013 and 2022 from the Web of Science database using VOSviewer, R software, and CiteSpace software.

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It is an urgent need to develop simple and high-throughput methods for simultaneously screening and detecting multiple or groups of sulfonamides (SAs) in animal-derived foods since various SAs were alternately used in animal husbandry to avoid generating drug resistance. We herein developed a novel HCl-reduced nicotinamide adenine dinucleotide I (NADH)-ascorbic acid (AA)-mediated gold nanobipyramids (AuNBPs) growth system, which can precisely regulate the growth rate of AuNBPs, to generate two colorful and stable AA-corresponding multicolor signal channels with different sensitivities. Based on the HCl-NADH-AA-mediated AuNBP growth system, we further developed a dual-channel multicolor immunoassay for simultaneously realizing rapid screening and detection of 5 SAs (sulfamethazine, sulfamethoxydiazine, sulfisomidine, sulfamerazine, and sulfamonomethoxine) by using a paper-based analytical device for sensitively and stably reading out the signal and a broad-specificity anti-SAs antibody as a bio-receptor.

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Article Synopsis
  • Higher manganese (Mn) levels in early pregnancy are associated with an increased risk of gestational diabetes mellitus (GDM), with the study showing that women in the highest plasma Mn quartiles had significantly elevated risks compared to those with the lowest levels.
  • *Among 2327 pregnant women analyzed, 9.7% were diagnosed with GDM, and the risk increased with higher Mn levels, suggesting a dose-response relationship.
  • *The study indicates that while Mn is essential for health, excessive levels during pregnancy could be an important risk factor for developing GDM, particularly affecting blood glucose levels.*
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Here, a colorimetric aptasensor was constructed for sensitively detecting quinclorac (QNC), a common herbicide. The aptasensor involved a novel amplification strategy and a classical strand displacement strategy. The amplification strategy, termed exonuclease III (Exo III)-assisted cyclic release of phosphorodiamidate morpholino oligomer (PMO) mimic enzyme strategy, was developed based on two new findings on PMO: 1) DNA hybridized with PMO could resist Exo III digestion; 2) a designed G-rich PMO (named P2) could bind to hemin to form a G-quadruplex PMOzyme with peroxidase-like activity.

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Accumulating evidence shows that gut microbial dysbiosis may represent a risk factor for Parkinson's disease (PD). Exercise has a positive effect on microbiota in general. The effect of aerobic exercise training (AET) on the gut microbial environment in PD remains to be explored.

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Parkinson's disease (PD) is a common complex neurodegenerative disease, and aerobic exercise (EX) has potential to improve motor dysfunction. This study aimed to explore whether EX acts on PD in mice mode. Mice were administered 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and subjected to a 4-week physical exercise regimen (EX-PD group) and underwent RNA-Seq.

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Background: Compliance with dietary guidelines among pregnant women can positively influence not only their own health but also the health of their babies. Measuring the compliance requires professional skills in nutrition and dietary counseling. In China, few simple and effective techniques assess dietary quality among pregnant women, especially in rural areas.

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Article Synopsis
  • This study aimed to explore the link between diet-related inflammation and the risk of gestational diabetes mellitus (GDM) among pregnant Chinese women by using the Dietary Inflammatory Index (DII).
  • Researchers analyzed data from 2,639 women and found a correlation between higher DII scores (indicating a more pro-inflammatory diet) and increased GDM risk, especially in those who were overweight or obese before pregnancy.
  • The results highlight that consuming a diet with a higher inflammatory potential may elevate the risk of developing GDM during pregnancy, emphasizing the importance of dietary choices for expectant mothers.
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Article Synopsis
  • The study investigated the impact of aerobic exercise training (AET) on mice suffering from Parkinson's disease (PD), finding significant improvements in their behaviors after 4 weeks of AET.
  • Histological analysis revealed changes in the substantia nigra of PD mice, with notable cell structures and surrounding inflammation after exercise.
  • AET was associated with 62 differentially expressed long noncoding RNAs (lncRNAs), suggesting potential molecular mechanisms, including pathways linked to cell interactions and signaling that may help in treating PD.
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A novel palladium-catalyzed ring opening carbonylative lactonization of readily available hydroxycyclopropanols was developed to efficiently synthesize tetrahydrofuran (THF) or tetrahydropyran (THP)-fused bicyclic γ-lactones, two privileged scaffolds often found in natural products. The reaction features mild reaction conditions, good functional group tolerability, and scalability. Its application was demonstrated in a short total synthesis of (±)-paeonilide.

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Article Synopsis
  • * Results showed that women taking high doses (≥800 µg/d) of FA supplements before and during early pregnancy had a significantly higher risk of developing GH compared to nonusers (risk ratio of 1.33).
  • * No significant link was found between FA supplement use and preeclampsia, suggesting that while high-dose FA may increase GH risk, it does not appear to affect preeclampsia rates.
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Objective: To examine optimal gestational weight gain(GWG) for Chinese pregnant women.

Methods: A total of 6998 women with singleton and term pregnancy recruited to the Tongji Maternal and Child Health Cohort during January 2013 to May 2016 in Wuhan, Hubei were included. Information on sociodemographic, medical and family history of disease was obtained by questionnaire, body weight and height were measured at the first antenatal care during 8-16 weeks of gestation.

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Background & Aims: Oxidative stress has been implicated in the pathogenesis of gestational diabetes mellitus (GDM). Vitamin C as natural antioxidant may help to increase the body's antioxidant capacity. The study is aimed to determine whether vitamin C intake during pregnancy is associated with lower risk of GDM.

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Objective: Fresh fruit intake has been found to be associated with risk of gestational diabetes mellitus (GDM); however, the evidence is limited and the findings are inconsistent. We aimed to assess the association of fresh fruit intake by fruit subgroups based on their glycemic index (GI) and glycemic load (GL) values and GDM incidence in Chinese pregnant women.

Methods: We included 3300 eligible women from the Tongji Maternal and Child Health Cohort.

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Background & Aims: Delayed onset of lactogenesis II (OL) negatively affects breastfeeding and consequently, the health of the newborn. Few studies have examined the association between gestational weight gain (GWG) throughout pregnancy and risk of delayed OL.

Methods: We used data from a prospective cohort study in Wuhan of China, which enrolled pregnant women at 8-16 weeks of gestation and followed-up regularly.

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Maternal dietary patterns and macronutrients intake have been shown to affect the development of gestational diabetes mellitus (GDM), but the findings are inconsistent. We aimed to identify maternal dietary patterns and examine their associations with GDM risk, and to evaluate the contributions of macronutrients intake to these associations. We included 2755 Chinese pregnant women from the Tongji Maternal and Child Health Cohort.

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Objectives: To examine the relationship between poor sleep quality during pregnancy and the risk of gestational diabetes mellitus (GDM).

Methods: A total of 4066 singleton pregnant women from the Tongji Maternal and Child Health Cohort (TMCHC) without overt diabetes before pregnancy were analyzed. Sleep quality and duration during early pregnancy were self-reported by enrolled women at their first antenatal care visit before 16 weeks of gestation.

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Background & Aims: Gestational diabetes mellitus is associated with adverse short- and long-term consequences for both the mother and the offspring. To examine the relationship between the rates of gestational weight gain (RGWG) during early and mid-pregnancy and the risk of gestational diabetes mellitus (GDM).

Methods: 2090 singleton pregnant women from the Tongji Maternal and Child Health Cohort (TMCHC) without overt diabetes before pregnancy were analyzed in our study.

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Objectives: To examine the association between sleep duration in early pregnancy and fetal growth in a prospective cohort study of 3567 Chinese women.

Methods: Pregnant women at 8-16 weeks of gestation were interviewed using a semi-quantitative questionnaire to assess sleep duration. Birth weight and birth length were measured by a midwife in the delivery room at birth; low birth weight (LBW) was defined as birth weight <2500 g and small for gestational age (SGA) was defined as <10th customized centile.

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Objectives: To examine the relationship between prenatal nitrogen dioxide (NO) exposure and foetal growth in a prospective cohort of 1001 Chinese women.

Methods: The maternal NO exposure levels were estimated using land-use regression models based on home address. The biparietal diameter (BPD), head circumference (HC), abdominal circumference (AC), femur length (FL) and estimated foetal weight (EFW) were evaluated via ultrasonography.

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Bilirubin concentrations have been recently reported to be negatively associated with type 2 diabetes mellitus. We examined the association between bilirubin concentrations and gestational diabetes mellitus. In a prospective cohort study, 2969 pregnant women were recruited prior to 16 weeks of gestation and were followed up until delivery.

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Synopsis of recent research by authors named "Xiating Li"

  • - Xiating Li's research focuses on the intersections of dietary impacts, maternal health, and innovative analytical methods, particularly in relation to gestational diabetes mellitus (GDM) and the use of tea in cancer research.
  • - Through comprehensive cohort studies, Li has identified important associations between dietary patterns, weight gain, and the risk of pregnancy complications, highlighting the implications of nutrition during pregnancy.
  • - Additionally, recent studies incorporate advanced techniques such as colorimetric immunoassays and aptasensors for detecting contaminants in food, illustrating Li's commitment to enhancing food safety and public health measures through scientific innovation.

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