Publications by authors named "Xiaozhong Wang"

In precision cancer therapy, addressing intra-tumor heterogeneity poses a significant obstacle. Due to the heterogeneity of each cell subtype and between cells within the tumor, the sensitivity and resistance of different patients to targeted drugs, chemotherapy, , are inconsistent. Concerning a specific tumor type, many feasible treatments or combinations can be used by specifically targeting the tumor microenvironment.

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Background: The occurrence and development of hematologic tumors are closely linked to cellular senescence. However, the molecular characteristics associated with this phenomenon in chronic myeloid leukemia (CML) have not been thoroughly investigated.

Methods: The cellular senescence score was calculated using gene set variation analysis.

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Objective: To explore the value of the systemic immune-inflammatory index (SII) and the systemic inflammatory response index (SIRI) in patients with severe hemorrhagic fever with renal syndrome (HFRS) upon admission.

Methods: This study included a total of 165 patients with HFRS, who were divided into mild and severe groups based on the severity of the disease. By reviewing medical records, we collected the white blood cell (WBC), SII, and SIRI values of patients upon admission.

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  • Brucellosis is a significant global health threat, particularly in China, where the illness persists despite extensive control measures.
  • A systematic review and meta-analysis of 80 studies revealed that the overall seroprevalence of bovine brucellosis in China is 1.5%, with higher rates in dairy cattle (3.1%) compared to beef cattle (1.3%) and yak (1.5%).
  • The study underscores the importance of monitoring brucellosis in cattle to predict and manage human cases, indicating that current prevention measures may not be sufficient for eradicating the disease.
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  • The study focuses on developing effective cathode materials for the photoelectrochemical CO reduction reaction (PEC CO RR) to convert carbon monoxide into valuable products using high-energy photoelectrons.
  • A coaxial ZnO@ZnSe heterostructure was created, enhanced by depositing metallic Bi nanoparticles on its surface, resulting in an efficient Bi/ZnO@ZnSe photocathode.
  • This photocathode design features a large surface area for better mass transfer and captures high-energy photoelectrons effectively, achieving over 88.9% Faradaic efficiency in CO conversion while maintaining stability.
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  • Esophageal cancer (ESCA) has a high rate of morbidity and mortality, especially in Asia, and the role of TERF2 in its development is not well understood, despite its importance in maintaining telomere stability.
  • The study assessed TERF2 expression in esophageal squamous cell carcinoma (ESCC) samples using various techniques, revealing that elevated TERF2 levels correlate with patient's age, sex, cancer stage, and other clinical factors.
  • Findings suggest TERF2 is an independent prognostic factor for overall survival in ESCC patients and may play a key role in cell proliferation through the DDR/TP53 signaling pathway, indicating its potential as a target for future treatments and diagnostics in ESCA.
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  • MARTX toxins are a type of delivery system found in various Gram-negative bacteria that infect mammals and other animals, but how they target host cells has been unclear.
  • Researchers identified a specific receptor-binding domain in a MARTX toxin from a dangerous foodborne bacteria, which consists of a 273-amino acid sequence resembling immunoglobulins.
  • This domain specifically binds to certain sugar structures (N-glycans) on the surface of host cells, making it crucial for the toxin's ability to cause disease during intestinal infections.
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It is urgent to develop an efficient and stable non-noble metal catalyst for selective C-H bond oxidation of cyclohexane. Herein, a series of V-W oxides supported on TiO catalysts (V-W/TiO) were fabricated. The V-W/TiO catalysts exhibited much higher catalytic activity for the selective oxidation of cyclohexane to KA oil, compared to that of V/TiO and W/TiO catalysts.

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Background: Previous studies have shown that macrophage-mediated efferocytosis is involved in immunosuppression in acute myeloid leukemia (AML). However, the regulatory role of efferocytosis in AML remains unclear and needs further elucidation.

Methods: We first identified the key efferocytosis-related genes (ERGs) based on the expression matrix.

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  • - Agricultural systems are significant contributors to global nitrous oxide (NO) emissions, largely due to over-fertilization and antibiotic residues, prompting global concern about environmental impacts.
  • - Research focused on how ciprofloxacin (CIP) increases NO production in soils by altering microbial processes, revealing that exposure leads to a shift from nitrification to denitrification and increases certain bacteria that produce NO.
  • - The study identifies a specific strain, Methylobacillus flagellatus KT, which can produce NO while also breaking down CIP, suggesting it uses CIP byproducts as food and highlighting its role in both NO emission and antibiotic degradation in soil ecosystems.
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Introduction And Objectives: Blood glucose fluctuates severely in the diabetes (DM) and tumor microenvironment. Our previous works have found Hepatitis B virus X protein (HBx) differentially regulated metastasis and apoptosis of hepatoma cells depending on glucose concentration. We here aimed to explore whether HBx played dual roles in the angiogenesis of hepatocellular carcinoma varying on different glucose levels.

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Background: Colorectal cancer (CRC) remains a global health concern with persistently high incidence and mortality rates. However, the specific pathogenesis of CRC remains poorly understood. This study aims to investigate the role and pathogenesis of serine and arginine rich splicing factor 10 (SRSF10) in colorectal cancer.

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Thyroid nodules (TNs) have emerged as the most prevalent endocrine disorder in China. Fine-needle aspiration (FNA) remains the standard diagnostic method for assessing TN malignancy, although a majority of FNA results indicate benign conditions. Balancing diagnostic accuracy while mitigating overdiagnosis in patients with benign nodules poses a significant clinical challenge.

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A metal-free (NH)SO-mediated decarboxylative trifluoromethylation reaction of alkenes with 3,3,3-trifluoro-2,2-dimethylpropionic acid has been proposed. This method offers a novel route for the direct synthesis of a series of CMeCF-containing quinazolinones from basic chemical raw materials. The reaction mechanism was studied by a radical trapping test and DFT methods, verifying an oxidation-triggered cascade process promoted by the CMeCF radicals.

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Background: The relationship between ferroptosis and the progression and treatment of hematological tumors has been extensively studied, although its precise association with chronic myeloid leukemia (CML) remains uncertain.

Methods: Multi-transcriptome sequencing data were utilized to analyze the ferroptosis level of CML samples and its correlation with the tumor microenvironment, disease progression, and treatment response. Machine learning algorithms were employed to identify diagnostic ferroptosis-related genes (FRGs).

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The tumor microenvironment (TME) is a highly heterogeneous ecosystem that plays critical roles in the initiation, progression, invasion, and metastasis of cancers. Extracellular vesicles (EVs), as emerging components of the host-tumor communication, are lipid-bilayer membrane structures that are secreted by most cell types into TEM and increasingly recognized as critical elements that regulate the interaction between tumor cells and their surroundings. They contain a variety of bioactive molecules, such as proteins, nucleic acids, and lipids, and participate in various pathophysiological processes while regulating intercellular communication.

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  • The study aimed to evaluate the effectiveness and tolerability of direct-acting antiviral (DAA) treatments for hepatitis C virus (HCV) across different genotypes (GTs) in a global, real-world context, focusing particularly on GT3 and GT6.
  • Researchers analyzed data from 15,849 chronic hepatitis C patients across Asia, North America, and Europe over a seven-year period, noting demographic factors such as age, sex, and prior treatment history.
  • Results showed a high sustained virological response (SVR12) rate of 96.9% overall, with variances by genotype, highlighting that independent factors like advanced age, cirrhosis, and previous treatment failures affected treatment outcomes, while being
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Background: Heterogeneous ribonucleoprotein A1 (hnRNPA1) has been reported to enhance the Warburg effect and promote colon cancer (CC) cell proliferation, but the role and mechanism of the miR-490-3p/hnRNPA1-b/PKM2 axis in CC have not yet been elucidated.

Aim: To investigate the role and mechanism of a novel miR-490-3p/hnRNPA1-b/PKM2 axis in enhancing the Warburg effect and promoting CC cell proliferation through the PI3K/AKT pathway.

Methods: Paraffin-embedded pathological sections from 220 CC patients were collected and subjected to immunohistochemical analysis to determine the expression of hnRNPA1-b.

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  • A clinical trial was conducted to compare the effectiveness and safety of two treatments—cetuximab plus FOLFOXIRI (triplet therapy) and cetuximab plus FOLFOX (doublet therapy)—in RAS/BRAF wild-type colorectal cancer patients who had unresectable liver metastases.
  • The study enrolled 146 patients across seven medical centers in China between April 2018 and December 2022, assessing their objective response rate and other outcomes such as tumor response and survival.
  • Results showed that the response rates were similar between the two treatment groups (84.7% for triplet vs. 79.7% for doublet), indicating no significant difference in efficacy, and the trial also monitored
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Presently, the improvement of soil organic matter is the basis to ensure food security, but the accumulation and transformation characteristics of soil phosphorus (P) as affected by organic matter remain unclear. The accumulation, transformation, and migration characteristics of soil P in different soil layers of vegetable fields were researched under the application of organic materials. Six treatments were set up in the experiment:control (no fertilization), traditional fertilizer application by farmers, biochar, chicken manure, food waste, and straw application.

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Background: Ovarian clear cell carcinoma (OCCC) represents a subtype of ovarian epithelial carcinoma (OEC) known for its limited responsiveness to chemotherapy, and the onset of distant metastasis significantly impacts patient prognoses. This study aimed to identify potential risk factors contributing to the occurrence of distant metastasis in OCCC.

Methods: Utilizing the Surveillance, Epidemiology, and End Results (SEER) database, we identified patients diagnosed with OCCC between 2004 and 2015.

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Background: Although chronic erosive gastritis (CEG) is common, its clinical characteristics have not been fully elucidated. The lack of consensus regarding its treatment has resulted in varied treatment regimens.

Aim: To explore the clinical characteristics, treatment patterns, and short-term outcomes in CEG patients in China.

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  • The OPTICAL trial explored the effectiveness of neoadjuvant chemotherapy (NAC) using mFOLFOX6 or CAPOX in treating locally advanced colon cancer compared to immediate surgery.
  • The study involved 752 patients, with those receiving NAC showing a 3-year disease-free survival (DFS) rate of 82.1% compared to 77.5% for the upfront surgery group.
  • While NAC didn't significantly improve DFS, it safely achieved lower tumor stages and better overall survival rates, making it a promising option for treatment.
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Returning organic nutrient sources (for example, straw and manure) to rice fields is inevitable for coupling crop-livestock production. However, an accurate estimate of net carbon (C) emissions and strategies to mitigate the abundant methane (CH) emission from rice fields supplied with organic sources remain unclear. Here, using machine learning and a global dataset, we scaled the field findings up to worldwide rice fields to reconcile rice yields and net C emissions.

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