Publications by authors named "Xiaozhen Qi"
Cell Biosci
December 2022
Article Synopsis
- - N-methyladenosine (mA) is a major modification in eukaryotic mRNA that significantly impacts cellular functions in cancer, necessitating a deeper understanding of its mechanisms.
- - The study identifies METTL3, an enzyme that adds mA, as being overexpressed in cervical cancer, where it acts as an oncogene by promoting the degradation of NR4A1 mA-modified transcripts.
- - The results suggest that overexpression of NR4A1 can slow down cancer progression by recruiting a complex that represses the AKT1 gene, highlighting the role of mA in cervical cancer dynamics.
Cell Mol Biol Lett
December 2022
Article Synopsis
- The study investigates the interaction between Argonaute 2 (AGO2) and a protein called PSMC3, which is essential for RNA interference (RNAi) in humans.
- Researchers used a yeast two-hybrid system to identify PSMC3 as a novel binding partner of AGO2, revealing that this interaction does not require RNA and is dependent on a specific region of PSMC3.
- Results showed that PSMC3 not only stabilizes AGO2 by preventing its degradation via ubiquitination but also enhances its expression, indicating a crucial role in regulating AGO2 activity within the RNAi pathway.
