Study on prevention and control measures of sandstone geothermal reinjection plugging.

In the process of geothermal tailwater reinjection of sandstone, the problem of plugging has been seriously restricting the continuous development of geothermal reinjection for many years, and the problems of plugging are complex and changeable. The plugging in the process of reinjection can be divided into physical plugging, chemical plugging, microbial plugging and gas plugging. Given these four types of blocking, according to the mechanism characteristics of the blocking caused by them, this paper puts forward corresponding blocking prevention measures and solves the current blocking problems by filtering, adding a scale inhibitor, intermittent reinjection, adding chlorine dioxide and regular lifting.

IL2-inducible T-cell kinase inhibitor ibrutinib reduces symptoms and Th2 differentiation in mouse allergic-rhinitis model.

Th2 and Th17 immune response contribute to allergic rhinitis (AR) development. Targeting Th2 and Th17 response has been shown to ameliorate AR. Ibrutinib is an inhibitor for IL2-inducible T-cell kinase, which can promote Th2 and Th17 immune response.

The calcimedin annexin A3 displays tumor-promoting effect in esophageal squamous cell carcinoma by activating NF-κB signaling.

Esophageal squamous cell carcinoma (ESCC) is one of the lethal malignancies commonly found in the eastern world, with overall five-year survival rates less than 25%. The present study aimed to investigate the biological function of annexin A3 (ANXA3) in ESCC cell proliferation. The mRNA and protein levels of ANXA3 in ESCC tissues and cell lines were determined by real-time PCR and Western blot, respectively.

Spleen Tyrosine Kinase Mediates Microglial Activation in Mice With Diabetic Retinopathy.

Purpose: Diabetic retinopathy (DR) is a leading cause of blindness in developed countries, in which microglial activation is involved. However, the mechanism of microglial activation in DR remains largely unknown.

Methods: We used Cx3cr1CreERT2; Sykfl/fl mice to knockout microglial spleen tyrosine kinase (Syk) in the retina of mice (cKO mice) after streptozotocin injection to induce diabetes.