Publications by authors named "Xiaoyun Lian"
Background: In clinical hematology, diffuse large B-cell lymphoma (DLBCL) is notably heterogeneous and varies in prognosis. Serum albumin (SA) is considered a biomarker of prognostic value in a number of hematologic malignancies. However, current knowledge of the association between SA levels and survival is limited, especially in DLBCL patients aged ≥70 years.
View Article and Find Full Text PDFA novel single-tube multiplex real-time PCR assay for genotyping of thiopurine intolerance-causing variant c.415C>T.
Exp Biol Med (Maywood)
September 2021
Thiopurines are commonly used in the treatment of acute lymphoblastic leukaemia and autoimmune conditions, can be limited by myelosuppression. The c.415C>T variant is strongly associated with thiopurine-induced myelosuppression, especially in Asians.
View Article and Find Full Text PDF[Low-dose Tertiary Prophylactic Therapy for Severe Haemophilia A Adults in A Single Medical Center in Beijing Area].
Zhongguo Yi Xue Ke Xue Yuan Xue Bao
August 2015
Article Synopsis
- This study examined the effects of low-dose tertiary prophylaxis on adults with severe hemophilia A, focusing on patients aged 18 to 60 who had existing joint issues.* -
- Researchers observed 22 patients during one year of on-demand treatment followed by one year of low-dose prophylaxis using plasma-derived factor 8 concentrates given 2-3 times a week.* -
- Results showed a significant reduction in annual bleeding frequency by 72.7%, improvements in joint health, and enhanced daily living activities, indicating better overall quality of life for participants.*
Article Synopsis
- Full-dose prophylaxis for haemophilia in China is too expensive, especially for adults needing higher clotting factor doses, leading to the implementation of low-dose prophylaxis since December 2009 due to government insurance covering 85% of costs in Beijing.
- A study analyzed 33 adults with severe haemophilia A who received low-dose prophylaxis and found a significant 71.1% reduction in annual bleeding rates and improvements in self-care and mobility, as measured by the Functional Independence Score in Haemophilia.
- Although joint health scores remained stable, 10 previously wheelchair-bound patients gained the ability to walk and manage daily activities independently, suggesting that low-dose prophylaxis is both feasible and beneficial for patients in
The purpose of this study was to analyze the effects of bufalin on the gene expression of K562 cells and on the expression of BMI‑1 pathway constituents in K562 cell apoptosis. K562 cells were treated with bufalin, and the inhibition rate and apoptosis were detected by an MTT assay, flow cytometry and a microarray assay. BMI‑1, p16INK4a and p14ARF were examined by quantitative polymerase chain reaction (qPCR).
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