The emerging role of sacubitril/valsartan in pulmonary hypertension with heart failure.

Pulmonary hypertension due to left heart disease (PH-LHD) represents approximately 65%-80% of all patients with PH. The progression, prognosis, and mortality of individuals with left heart failure (LHF) are significantly influenced by PH and right ventricular (RV) dysfunction. Consequently, cardiologists should devote ample attention to the interplay between HF and PH.

Glutathione -Transferase Alpha 4 Promotes Proliferation and Chemoresistance in Colorectal Cancer Cells.

Glutathione -transferase alpha 4 (GSTA4) is a phase II detoxifying enzyme that is overexpressed in colorectal cancer (CRC) and regulated by the oncogenic transcription factor AP-1. However, the role of GSTA4 in these CRC cells remains unclear. In this study, we investigated the roles of GSTA4 in the CRC cells by inactivating GSTA4 in HCT116 human CRC cells (Defined as HCT116) using the CRISPR/Cas9 gene editing.

A Signature for Smoking Status of Coronary Heart Disease Patients through Weighted Gene Coexpression Network Analysis.

Background: Smoking is one of the risk factors of coronary heart disease (CHD), while its underlying mechanism is less well defined.

Purpose: To identify and testify 6 key genes of CHD related to smoking through weighted gene coexpression network analysis (WGCNA), protein-protein interaction (PPI) network analysis, and pathway analysis.

Methods: CHD patients' samples were first downloaded from Gene Expression Omnibus (GEO).

Construction of a Support Vector Machine-Based Classifier for Pulmonary Arterial Hypertension Patients.

Pulmonary arterial hypertension (PAH) is a disease leading to right heart failure and death due to increased pulmonary arterial tension and vascular resistance. So far, PAH has not been fully understood, and current treatments are much limited. Gene expression profiles of healthy people and PAH patients in GSE33463 dataset were analyzed in this study.

Extracellular Mitochondrial Components and Effects on Cardiovascular Disease.

Besides being powerhouses of the cell, mitochondria released into extracellular space act as intercellular signaling. Mitochondria and their components mediate cell-to-cell communication in free form or embedded in a carrier. The pathogenesis of cardiovascular disease is complex, which shows close relationship with inflammation and metabolic abnormalities.

Optimization of Ring Laser Gyroscope Bias Compensation Algorithm in Variable Temperature Environment.

In a high accuracy strapdown inertial navigation system (SINS), the ring laser gyroscope's (RLG) bias changes and the performance decreases due to factors in the RLG's self-heating and changes in ambient temperature. Therefore, it is important to study the bias temperature drift characteristics of RLGs in high, low, and variable temperature environments. In this paper, a composite temperature calibration scheme is proposed.