Publications by authors named "Xiaoyue Kang"

Article Synopsis
  • White blood cells (WBCs) are essential for monitoring health and diagnosing diseases, but isolating them from blood is challenging due to their low concentration compared to red blood cells (RBCs).
  • Researchers developed a cascaded inertial microfluidic chip that improves WBC separation purity by using two sinusoidal channels and embedded micro-obstacles to control flow rate during processing.
  • The method significantly enhanced WBC purity, achieving a 307-fold increase in WBC concentration from diluted whole blood and a dramatic reduction in RBC presence, making it promising for clinical diagnostics.
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Viscoelastic microfluidics leverages the unique properties of non-Newtonian fluids to manipulate and separate micro- or submicron particles. Channel geometry and dimension are crucial for device performance. Traditional rigid microfluidic devices require numerous iterations of fabrication and testing to optimize these parameters, which is time-consuming and costly.

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Microfluidics, the science and technology of manipulating fluids in microscale channels, offers numerous advantages, such as low energy consumption, compact device size, precise control, fast reaction, and enhanced portability. These benefits have led to applications in biomedical assays, disease diagnostics, drug discovery, neuroscience, and so on. Fluid flow within microfluidic channels is typically in the laminar flow region, which is characterized by low Reynolds numbers but brings the challenge of efficient mixing of fluids.

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Inertial microfluidics uses the intrinsic fluid inertia in confined channels to manipulate the particles and cells in a simple, high-throughput, and precise manner. Inertial focusing in a straight channel results in several equilibrium positions within the cross sections. Introducing channel curvature and adjusting the cross-sectional aspect ratio and shape can modify inertial focusing positions and can reduce the number of equilibrium positions.

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Pretreatment of activated sludge is an important step in increasing the reaction speed during anaerobic digestion by accelerating the hydrolysis process. It is necessary not only to analyze the changes in the general properties of the sludge before and after pretreatment but also to further analyze and evaluate the sludge structure and extracellular polymeric substances (EPS). In this study, the changes in coking sludge extracts after pretreatments with alkali, autoclaving, and Fe+ autoclaving were analyzed and compared using EPS heat extraction method.

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