Publications by authors named "Xiaoyu Zhou"

With the progress of hematopoietic stem cell transplantation technology, the reduction of pretreatment intensity, the shortening of bone marrow suppression time and the reduction of infection risk, as well as the prominent physical and psychological stress for doctors and patients caused by rigorous protection procedures, the strategies for protective environment need to be reconsidered. Regardless of whether total environment protection is implemented, there is no significant difference in the outcomes of chemotherapy patients with neutropenia. The advantages and disadvantages of total environment protection have been weighed and reviewed for patients receiving hematopoietic stem cell transplantation.

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  • Aberrant microRNA (miRNA) expression is linked to various cancers, creating the need for effective detection methods for cancer diagnosis and therapy.
  • The study introduces a novel approach by creating cholesterol-DNA micelles attached to amplification products, allowing for efficient signal amplification through a designed nanoprobe (RC-HCR) that detects miRNA levels in living cells.
  • The RC-HCR probe demonstrated high sensitivity (1 fM detection limit), wide quantification range, and selectivity in distinguishing wild-type miR-21 from its variants, showcasing its potential as a powerful tool for early cancer diagnosis.
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This paper presents the damage characteristics of digital protective relays (DPR) in substations under high-altitude electromagnetic pulse (HEMP) environments through radiated and conducted tests. Three representative substation circuits of DPR are selected, and the radiated and conducted experiments are performed. Through a comprehensive analysis of the radiated and conducted test results, the damage characteristics of DPRs under the HEMP environment are determined, including port coupling characteristics and vulnerability, respectively.

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An efficient and convenient method for the synthesis of C3-hydroxytrifluoroalkylated indoles and pyrroles was described in this paper. The copper-catalyst-free site-specific cross-dehydrogenative coupling reaction of various indoles and pyrroles with hexafluoroisopropanol proceeded smoothly by using MnO as oxidant to furnish a hydroxytrifluoroalkylated electron-rich -heterocycle in satisfactory to excellent yields. Various groups, including the synthetically useful functional groups Cl, NO, and CN, were tolerated well.

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  • Vigilance decrement, a decrease in attention over time, is a common issue in tasks requiring high focus, prompting the need for neuromodulation methods like rhythmic visual stimulation (RVS).
  • A study with 30 participants showed that 40-Hz gamma flicker RVS improved perceptual sensitivity during a 12-minute attention task, countering the negative effects of vigilance decrement.
  • EEG data revealed that this RVS increased theta-band activity in the prefrontal cortex, suggesting a connection between visual stimulation and enhanced attentional resource use during prolonged tasks.
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Relapse is one of the major challenges in clinical treatment of acute myeloid leukemia (AML). Though minimal residual disease (MRD) monitoring plays a crucial role in quantitative assessment of the disease, molecular MRD analysis has been mainly limited to patients diagnosed with gene fusions and NPM1 mutations. Here, we report a longitudinal ultra-sensitive mutation burden (UMB) monitoring strategy for accurate MRD analysis in AML patients regardless of genetic abnormality types.

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Background: Percutaneous coronary intervention (PCI) helps treat coronary artery disease but only provides short-term relief and doesn't stop disease progression. Exercise rehabilitation can improve outcomes for patients after PCI and lower the risk of death and new heart problems, but many patients struggle to stick with their exercise routines. Spouses play a crucial role in supporting patients and helping them stay committed to their rehabilitation.

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Background And Aims: Tenecteplase (TNK) offers logistical advantages in stroke thrombolytic therapy with its single bolus administration compared with alteplase. We aim to investigate the real-world evidence regarding its safety and effectiveness in China.

Methods: We conducted a retrospective study on patients receiving alteplase or TNK for acute ischaemic stroke (AIS) within 4.

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  • Base editors allow for precise changes in genetic material without causing double-strand breaks, making them useful for disease modeling and gene therapy, but their use is limited due to the need for specific PAM sequences.
  • Researchers developed four near-PAMless base editor versions that broaden the range of target sequences and found that both the PAM and surrounding sequences influence editing efficiency.
  • The team created BEguider, a deep learning model that predicts editing results for these new editors and provided experimental editing data on 20,541 ClinVar sites, showing that previously difficult-to-edit variants can now be addressed accurately; the predictive tool and data are available for public use.
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This paper investigates the aeration and oxygen transfer characteristics within the aeration tank of an integrated wastewater treatment system (IWTS) using Computational Fluid Dynamics coupled with Population Balance Model and oxygen transfer model. The findings suggest that increasing the air flow rate significantly enhances the oxygen transfer rate, albeit at a decreasing rate of growth. The oxygen overall mass transfer coefficient is primarily influenced by the interfacial area per unit volume and to a lesser by the oxygen mass transfer coefficient (k).

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  • Intrahepatic cholestasis of pregnancy (ICP) is a condition affecting pregnant women, marked by itching, liver dysfunction, and high bile acid levels, potentially linked to immune system issues.
  • Researchers analyzed placenta samples using advanced sequencing technologies to understand the immune cell behaviors and genetic mechanisms involved in ICP.
  • Findings revealed that macrophages in the placenta are significantly increased and show distinct gene expression patterns, indicating a shift toward inflammation that could contribute to the condition's complications.
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To investigative the white matter (WM) alterations in lung cancer patients with cancer pain (CP+), and explore the correlations between damaged WM fiber tracts and clinical indicators. Twenty-six CP+, 26 lung cancer patients without CP (CP-), and 31 healthy controls (HC) were recruited. All participants underwent diffusion tensor imaging (DTI) and clinical assessments.

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African swine fever (ASF), caused by the African swine fever virus (ASFV), has resulted in significant losses in the global pig industry. Considering the absence of effective vaccines, developing drugs against ASFV may be a crucial strategy for its prevention and control in the future. In this study, punicalagin, a polyphenolic substance extracted from pomegranate peel, was found to significantly inhibit ASFV replication in MA-104, PK-15, WSL, and 3D4/21 cells by screening an antiviral compound library containing 536 compounds.

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  • - This study investigates the connections between glaucoma, brain changes, and Alzheimer’s disease to understand how they might influence each other, particularly looking at genetic correlations.
  • - Researchers found that certain genetic factors related to glaucoma may decrease the risk of developing Alzheimer’s disease and identified multiple brain regions that show links to both conditions.
  • - The results suggest complex relationships between glaucoma and Alzheimer’s, indicating that changes in brain structures may mediate these connections, but further research is needed to clarify these effects.
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Background: The safety of extracorporeal shock wave lithotripsy for pancreatic stones (P-ESWL) and adverse events were not evaluated and classified within large sample population. This study aimed to evaluate the safety and classify the adverse events of P-ESWL based on a large sample cohort.

Methods: This is an observational study based on the large prospective chronic pancreatitis (CP) cohort.

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Pulse generators with high voltage and several nanoseconds of rise time are typically used to carry out the equivalent assessment of the protection performance of typical power equipment in the high-altitude electromagnetic pulse environment. In this paper, a pulse generator with high voltage and fast rise time has been designed, and the diagnostic system with high temporal resolution has been integrated to measure the output pulse voltage of the generator. The experimental results showed that the output pulse voltage of the generator on the output load can reach 645 kV when the charged voltage of Marx generator capacitors is 40 kV.

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 The primary purpose of this study was to assess the practicability of predeposit autologous blood donation (PABD) in the practice of Rh(D)-negative pregnant women.  A cohort of 405 Rh(D)-negative pregnant women who had a delivery in the comprehensive tertiary hospital in Nanjing was analyzed retrospectively, over 10 years.  After PABD, 203 women experienced a slight drop in mean hemoglobin of 5.

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The leakage field of a hybrid electromagnetic pulse simulator with horizontal polarization is simulated and experimentally investigated based on the finite integration technique in this paper. The field distribution characteristics and far-field radiation pattern of the simulator are given. The attenuation characteristics of the electric field at specific directions in the z = 2 m plane are also predicted by numerical data fitting.

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  • A study evaluated how blood pressure variability affects outcomes in patients with acute basilar artery occlusion undergoing mechanical thrombectomy, involving 108 patients monitored for 24 hours post-procedure.
  • It found that greater variability in mean arterial pressure (MAP) was linked to increased rates of futile recanalization and higher 30-day mortality, with significant implications for treatment strategies.
  • The negative impact of blood pressure variability was notably more pronounced in patients who did not have a history of hypertension.
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A new trifluoroacetylation reagent was developed by using inexpensive and readily available trifluoroacetic anhydride and -phenyl-4-methylbenzenesulfonamide for the first time. The reaction of (het)aryl boronic acids with the new trifluoroacetylation reagent, -phenyl--tosyltrifluoroacetamide, proceeded smoothly in the presence of a palladium catalyst to provide trifluoromethyl ketones in satisfactory to excellent yields. Various groups, including the synthetically useful functional groups Cl, TMS, and PhCO, were tolerated well under the current reaction conditions.

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Background: Age-related eye diseases (AREDs) have become increasingly prevalent with the aging population, serving as the leading causes of visual impairment worldwide. Epigenetic clocks are generated based on DNA methylation (DNAm) levels and are considered one of the most promising predictors of biological age. This study aimed to investigate the bidirectional causal association between epigenetic clocks and common AREDs or glaucoma endophenotypes.

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Phosphine catalysis generally relies on the potential of carbanion-phosphonium zwitterions that are generated via nucleophilic addition of phosphine catalyst to electrophilic reactants. Consequently, structural modification of zwitterions using distinct electrophilic reactants has emerged as a prominent strategy to enhance catalysis diversity. Herein, we present an alternative strategy that utilizes AgF additive to expand phosphine catalysis.

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Synopsis of recent research by authors named "Xiaoyu Zhou"

  • - Xiaoyu Zhou's recent research focuses on the intersection of big data, ophthalmology, and gene editing technologies, highlighting innovations that cater to specific needs in medical applications and environmental technology.
  • - A key finding from Zhou's studies includes the identification of significant trends in big data utilization in ophthalmology, as well as the development of near-PAMless base editors which enhance editing efficiencies critical for gene therapy.
  • - Additional work investigates the safety of medical procedures, such as extracorporeal shock wave lithotripsy for pancreatic stones, and explores the implications of white matter changes in lung cancer patients, underscoring the multifaceted approach of Zhou's research in addressing clinical and biotechnological challenges.