Magnetic Nanoactuator-Protein Fiber Coated Hydrogel Dressing for Well-Balanced Skin Wound Healing and Tissue Regeneration.

Despite significant progress in skin wound healing, it is still a challenge to construct multifunctional bioactive dressings based on a highly aligned protein fiber coated hydrogel matrix for antifibrosis skin wound regeneration that is indistinguishable to native skin. In this study, a "dual-wheel-driven" strategy is adopted to modify the surface of methacrylated gelatin (GelMA) hydrogel with highly aligned magnetic nanocomposites-protein fiber assemblies (MPF) consisting of photothermal responsive antibacteria superparamagnetic nanocomposites-fibrinogen (Fg) complexes as the building blocks. Whole-phase healing properties of the modified hydrogel dressing, GelMA-MPF (GMPF), stem from the integration of Fg protein with RGD peptide activity decorated on the surface of the antibacterial magnetic nanoactuator, facilitating facile and reproducible dressing preparation by self-assembly and involving biochemical, morphological, and biophysical cues.

Emergence of Omicron FN.1 a descendent of BQ.1.1 in Botswana.

Botswana, like the rest of the world, has been significantly impacted by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In December 2022, we detected a monophyletic cluster of genomes comprising a sublineage of the Omicron variant of concern (VOC) designated as B.1.

Genomic epidemiology and immune escape of SARS-CoV-2 recombinant strains circulating in Botswana.

Objectives: We characterized the molecular and mutational landscape of SARS-CoV-2 recombinant strains in Botswana.

Methods: We performed genomic, phylogenetic, and immunoinformatic analyses of 5254 near-complete genomes from 2020 to 2023. We assessed the presence of mutations of interested (MutOI) that may be associated with immune escape .

ARC protects cochlear hair cells from neomycin-induced ototoxicity via the Ras/JNK signaling pathway.

The present study was designed to investigate the role and mechanism of the Apoptosis repressor with caspase recruitment domain (ARC) in protecting the neomycin-induced hair cell damage. HEI-OC1 cells and basilar membrane culture were applied to determine the effect of ARC. Plasmid transfection was used to regulate the ARC or Ras expression.

Thiosulfate-Mediated Polysulfide Redox for Energetic Aqueous Battery.

Sulfur-based aqueous batteries (SABs) are regarded as promising candidates for safe, low-cost, and high-energy storage. However, the sluggish redox kinetics of polysulfides pose a significant challenge to the practical performance of SABs. Herein, we report a unique redox regulation strategy that leverages thiosulfate-mediated ligand-chain interaction to accelerate the polysulfide redox process (S/S).

A spatial machine learning approach to exploring the impacts of coal mining and ecological restoration on regional ecosystem health.

Ecosystem health is an important approach to measuring urban and regional sustainability. In previous studies, the spatiotemporal changes of ecosystem health have been addressed using comprehensive assessment index system. However, the quantitative contribution of human activities and climate change to ecosystem health was less examined.

A phylogenetics and variant calling pipeline to support SARS-CoV-2 genomic epidemiology in the UK.

In response to the escalating SARS-CoV-2 pandemic, in March 2020 the COVID-19 Genomics UK (COG-UK) consortium was established to enable national-scale genomic surveillance in the UK. By the end of 2020, 49% of all SARS-CoV-2 genome sequences globally had been generated as part of the COG-UK programme, and to date, this system has generated >3 million SARS-CoV-2 genomes. Rapidly and reliably analysing this unprecedented number of genomes was an enormous challenge.

Blocking donor liver Pannexin 1 channels facilitates mitochondria protection during liver transplantation.

Static cold storage (SCS) is the standard technique for organ preservation during transplantation, resulting in cold ischemic injury. Hypoxia can induce pannexin 1 (Panx1) channels to open, leading to release of adenosine triphosphate. However, it is unknown if Panx1 plays a role in SCS.

Luteolin Protects against Vascular Calcification by Modulating SIRT1/CXCR4 Signaling Pathway and Promoting Autophagy.

Vascular calcification (VC) is a common pathological manifestation of atherosclerosis, hypertension, diabetes vascular disease, vascular injury, chronic kidney disease and aging, which is mainly manifested as increased stiffness of the vascular wall. Oxidative stress and autophagy dysfunction are key factors in the pathogenesis of vascular calcification, but the specific mechanisms and the therapeutic strategy of vascular calcification have not been clarified. In the present study, Sirtuin 1 (SIRT1) was screened as the therapeutic targets for vascular calcification by the bioinformatics.

Electrolyte Solvation Engineering Stabilizing Anode-Free Sodium Metal Battery With 4.0 V-Class Layered Oxide Cathode.

Anode-free sodium metal batteries (AFSMBs) are regarded as the "ceiling" for current sodium-based batteries. However, their practical application is hindered by the unstable electrolyte and interfacial chemistry at the high-voltage cathode and anode-free side, especially under extreme temperature conditions. Here, an advanced electrolyte design strategy based on electrolyte solvation engineering is presented, which shapes a weakly solvating anion-stabilized (WSAS) electrolyte by balancing the interaction between the Na-solvent and Na-anion.

Research and implementation of a large-bandwidth real-time radar jamming simulator.

The electromagnetic environment faced by modern radar is becoming increasingly complex. One effective means to improve the performance of radar systems is testing in an anti-jamming ability test chamber, where the increased complexity has also led to higher performance requirements for radar jamming simulators. Based on the requirements for modern radar system testing, this paper presents a study of a large-bandwidth real-time radar jamming simulator and describes its overall design architecture; the simulator covers the L-Ku and Ka frequency bands and the instantaneous bandwidth is ≥2 GHz, which means that the system is able to simulate 11 interference patterns.

Platinum-based fluorescent nanozyme-driven "loong frolic pearls" multifunctional nanoplatform for tri-mode ultrasensitive detection and synergistic sterilization of Burkholderia gladioli.

Rapid and accurate detection of Burkholderia gladioli (B. gladioli) and effective sterilization are crucial for ensuring food safety. Hence, a novel "loong frolic pearls" platform based on platinum-based fluorescent nanozymes (Pt-OCDs) and strand exchange amplification (SEA) was reported.

"Four - in - one" platform based on multifunctional nanozyme for ultra - accurate detection and on - demand disinfection of Listeria monocytogenes.

The inability to integrate detection and disinfection hindered building a unified pathogen monitoring platform, risking secondary contamination. Herein, a novel "four - in - one" platform for monitoring foodborne Listeria monocytogenes (L. monocytogenes) was presented.

High-Valent Thiosulfate Redox Electrochemistry for Advanced Sulfur-Based Aqueous Batteries.

Sulfur-based aqueous batteries (SABs) are promising for safe, low-cost, and high-capacity energy storage. However, the low output voltage of sulfur cannot meet the demands of high-energy cathode applications due to its intrinsic negative potential (E = -0.51 V vs SHE) of low-valent polysulfide redox (S/S).

Intervertebral Disc-on-a-Chip: A New Model for Mouse Disc Culture via Integrating Mechanical Loading and Dynamic Media Flow.

This study aims to develop an organ-on-a-chip model, intervertebral Disc-on-a-Chip, to investigate integrated effects of mechanical loading and nutrition on disc health. The system consists of a detachable multilayer microfluidic chip, a Computer-Arduino-based control system, and a mechanical loading unit, which were optimized for accurate axial force measurement and the maintenance of a 21-day disc culture. To ensure accuracy of axial force, we optimized the axial mechanical loading regimen, used the Computer-Arduino-based system and low-profile force sensors (LPFS) to control the mechanical loading unit, and modeled the force distribution by using computational simulation.

Full-Dimensional Analysis of Gaseous Products to Unlocking In Depth Thermal Runaway Mechanism of Li-Ion Batteries.

In this study, state-of-the-art on-line pyrolysis MS (OP-MS) equipped with temperature-controlled cold trap and on-line pyrolysis GC/MS (OP-GC/MS) injected through high-vacuum negative-pressure gas sampling (HVNPGS) programming are originally designed/constructed to identify/quantify the dynamic change of common permanent gases and micromolecule organics from the anode/cathode-electrolyte reactions during thermal runaway (TR) process, and corresponding TR mechanisms are further perfected/complemented. On LiC anode side, solid electrolyte interphase (SEI) would undergo continuous decomposition and regeneration, and the R-H (e.g.

Artificial intelligence-assisted metastasis and prognosis model for patients with nodular melanoma.

Objective: The objective of this study was to identify the risk factors that influence metastasis and prognosis in patients with nodular melanoma (NM), as well as to develop and validate a prognostic model using artificial intelligence (AI) algorithms.

Methods: The Surveillance, Epidemiology, and End Results (SEER) database was queried for 4,727 patients with NM based on the inclusion/exclusion criteria. Their clinicopathological characteristics were retrospectively reviewed, and logistic regression analysis was utilized to identify risk factors for metastasis.

Striking the balance: Configurations of causation and effectuation principles for SME performance.

Causation and effectuation are two fundamental decision-making logics that managers use for crucial firm strategic decisions. However, existing research has yet to agree on the relationship between the two logics, supporting both the substitution and complementarity of causation and effectuation in influencing firm performance. This leaves us with a puzzle: How do causation and effectuation combine in balance to improve firm performance? To address the gap, we utilize a fuzzy set qualitative comparative analysis (fsQCA) with data collected from 344 small to medium-sized enterprises (SMEs) in China to uncover the dynamic relationships between the two logics.

Unlocking Dynamic Solvation Chemistry and Hydrogen Evolution Mechanism in Aqueous Zinc Batteries.

Understanding the interfacial hydrogen evolution reaction (HER) is crucial to regulate the electrochemical behavior in aqueous zinc batteries. However, the mechanism of HER related to solvation chemistry remains elusive, especially the time-dependent dynamic evolution of the hydrogen bond (H-bond) under an electric field. Herein, we combine in situ spectroscopy with molecular dynamics simulation to unravel the dynamic evolution of the interfacial solvation structure.

Impact of PRR11 Expression on Prognosis in Pancreatic Cancer Patients with Diabetes.

Objective: This study aimed to analyze the impact of PRR11 protein expression levels on the prognosis of patients with diabetes mellitus and pancreatic cancer.

Methods: Immunohistochemical staining was performed to detect the expression levels of PRR11 protein in cancerous tissues of 70 pancreatic cancer patients, including 45 patients with diabetes mellitus (Group A) and 25 patients without diabetes mellitus (Group B). Patients' blood glucose, lipid profiles, and glycemic control status were compared between the groups.