Publications by authors named "Xiaoyu Xia"

Purpose: Spine is the most commonly found fracture site due to osteoporosis. Combined exercise including high-impact and resistance exercise shows the potential to improve bone mineral density (BMD) in the spine. However, the mechanical loading introduced by exercise, which is the mechanism of BMD changes, has not been investigated.

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  • Applying artificial intelligence in healthcare, especially for STI and HIV prediction, is crucial but requires protecting sensitive data through advanced methods.
  • The study utilized federated learning and homomorphic encryption on a large dataset from eight countries, training models without compromising privacy.
  • Results showed significant performance improvement in predicting risk, with AUC rising from 0.78 to 0.94, indicating the effectiveness of decentralized data analysis in enhancing healthcare outcomes.
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As a significant component of executive function, goal-directed attentional control is crucial for cognitive processing and is closely linked to frontal-midline theta (FMT) rhythms. However, how up-regulation and down-regulation of FMT through neurofeedback training (NFT) impact goal-directed attention control remains unclear, especially for both short-term and long-lasting effects. Therefore, this study employed a single-blind sham-controlled between-subject design to answer this question.

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Dexamethasone (DEX) is used to treat ocular surface diseases. However, regulating DEX duration in tears while preventing its absorption into the anterior chamber is critical for balancing its therapy effects and the side effects. In this study, a novel magnetic nanoparticle (MNP)-micelle (MC) co-delivery system (MMDS) was developed.

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Mitochondrial DNA (mtDNA) is pivotal for mitochondrial morphology and function. Upon mtDNA damage, mitochondria undergo quality control mechanisms, including fusion, fission, and mitophagy. Real-time monitoring of mtDNA enables a deeper understanding of its effect on mitochondrial function and morphology.

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G-quadruplex (G4) structures play integral roles in modulating biological functions and can be regulated by small molecules. The MYC gene is critical during tumor initiation and malignant progression, in which G4 acts as an important modulation motif. Herein, we reported the MYC promoter G4 recognized by a platinum(II) compound Pt-phen.

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To improve the understanding and diagnostic accuracy of disorders of consciousness (DOC) by quantifying transcranial magnetic stimulation (TMS) evoked electroencephalography connectivity using permutation conditional mutual information (PCMI).PCMI can characterize the functional connectivity between different brain regions. This study employed PCMI to analyze TMS-evoked cortical connectivity (TEC) in 154 DOC patients and 16 normal controls, focusing on optimizing parameter selection for PCMI (Data length, Order length, Time delay).

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  • Inflammatory bowel disease (IBD) is associated with oxidative stress and inflammasome activation, and the natural antioxidant nobiletin (NOB) shows promise in treating intestinal injuries, but its effectiveness is limited by low water solubility and bioavailability.
  • Researchers developed a NOB-loaded yeast microcapsule (YM, NEFY) that enhances NOB's therapeutic effects for ulcerative colitis using a metal polyphenol network to significantly improve NOB encapsulation.
  • NEFY microcapsules facilitate targeted delivery to the intestines, reduce inflammation and oxidative stress, and support recovery from colitis by inhibiting the NLRP3 inflammasome and promoting proper macrophage function.
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Background: Non-invasive brain stimulation is considered as a promising technology for treating patients with disorders of consciousness (DOC). Various approaches and protocols have been proposed; however, few of them have shown potential effects on patients with vegetative state (VS). This study aimed to explore the neuro-modulation effects of intermittent theta burst stimulation (iTBS) on the brains of patients with VS and to provide a pilot investigation into its possible role in treating such patients.

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Ferritin nanocages possess remarkable structural properties and biological functions, making them highly attractive for applications in functional materials and biomedicine. This comprehensive review presents an overview of the molecular characteristics, extraction and identification of ferritin, ferritin receptors, as well as the advancements in the directional design of high-order assemblies of ferritin and the applications based on its unique structural properties. Specifically, this Review focuses on the regulation of ferritin assembly from one to three dimensions, leveraging the symmetry of ferritin and modifications on key interfaces.

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This paper presents a solution that prioritises high privacy protection and improves communication throughput for predicting the risk of sexually transmissible infections/human immunodeficiency virus (STIs/HIV). The approach utilised Federated Learning (FL) to construct a model from multiple clinics and key stakeholders. FL ensured that only models were shared between clinics, minimising the risk of personal information leakage.

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Background: The increasing attention toward frozen soy-based foods has sparked interest. Variations exist in the quality and structure of soymilk gels induced by different salt ions, leading to diverse changes post-freezing. This study compared and analyzed the effects of calcium chloride (CC), magnesium chloride (MC) and calcium sulfate (CS) on the quality characteristics and protein structure changes of soymilk gels (CC-S, MC-S and CS-S) before and after freezing, and clarified the mechanisms of freezing on soymilk gel.

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  • The study examines the use of mismatch negativity (MMN) as a tool for assessing consciousness levels in patients with disorders of consciousness (DoC), focusing on its effectiveness in differentiating between vegetative state/unresponsive wakefulness syndrome (UWS) and minimally conscious state (MCS).
  • Researchers analyzed EEG data from 67 DoC patients using various MMN amplitude representations, discovering that a specific microstate (MS1) provided significant results during the 100-250 ms interval.
  • The findings indicate that the microstate analysis of MMN shows high accuracy (AUC = 0.89) in predicting consciousness levels, suggesting it could serve as an effective model for distinguishing between MCS and UWS states.
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Accurate prognostic prediction in patients with disorders of consciousness (DOC) is a core clinical concern and a formidable challenge in neuroscience. Resting-state EEG has shown promise in identifying electrophysiological prognostic markers and may be easily deployed at the bedside. However, the lack of brain dynamic modeling and the spatial mixture of signals in scalp EEG have constrained our exploration of biomarkers and comprehension of the mechanisms underlying consciousness recovery.

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MnO is a nanozyme that inhibits the decomposition of hydrogen peroxide (HO) into a hydroxyl radical (OH), thus preventing its conversion into reactive oxygen species (ROS). Oyster ferritin (GF1) is a macromolecular protein that provides uniform size and high stability and serves as an excellent template for the biomineralization of nanozyme. This study presents a unique method in which MnO is grown in situ in the GF1 cavity, yielding a structurally stable ferritin-based nanozyme (GF1@Mn).

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Background: Lycopene (LYC), a carotenoid found in abundance in ripe red fruits, exhibits higher singlet oxygen quenching activity than other carotenoids. However, the stability of LYC is extremely poor due to its high double-bond content. In this paper, a nano-encapsulation strategy based on highly stable marine-derived ferritin GF1 nanocages was used to improve the thermal stability and oxidation resistance of LYC, thereby boosting its functional effectiveness and industrial applicability.

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  • The study investigates the effects of two types of nanocellulose, CNC and CNF, on the properties of a soy protein isolate and konjac glucomannan composite hydrogel.
  • It was found that optimal amounts of CNC and CNF enhanced gel strength and elasticity, respectively, by improving molecular interactions and structural integrity.
  • However, adding too much CNF (≥0.75%) disrupted the balance between proteins and polysaccharides, compromising the gel's stability, highlighting the importance of dosage in these composite systems.
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Purpose: To identify risk factors for major postoperative complications in meningioma patients and to construct and validate a nomogram that identify patients at high risk of these complications.

Methods: The medical records of meningioma patients who underwent surgical resection in our hospital from January 2018 to December 2020 were collected. The patients were divided into a training set (815 cases from the main campus in 2018 and 2019) and a validation set (300 cases from two other campuses in 2020).

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Objective: The application of spinal cord stimulation (SCS) in the treatment of disorders of consciousness (DOC) has attracted attention, but its effect on brain activity is still unknown. Transcranial magnetic stimulation combined with EEG (TMS-EEG) can measure cortical activity, which can evaluate the effect of SCS on DOC.

Methods: We record 20 DOC patients' CRS-R values and TMS-EEG data before and after one-session SCS (Pre-SCS and Post-SCS).

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  • Mulberry is crucial for the sericulture industry and has significant health and environmental benefits, yet previous reference genomes for mulberry were incomplete.
  • This study presents a complete, gap-free reference genome for a specific mulberry species, enhancing research on gene function and genetic improvement.
  • The findings reveal that this species has unique polycentric chromosomes and proposes a model for the formation of new centromeres, contributing to our understanding of chromosome evolution and functional genomics in mulberries.
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Background: Deep brain stimulation (DBS) in the centromedian-parafascicular complex (CM-pf) has been reported as a potential therapeutic option for disorders of consciousness (DoC). However, the lack of understanding of its electrophysiological characteristics limits the improvement of therapeutic effect.

Objective: To investigate the CM-pf electrophysiological characteristics underlying disorders of consciousness (DoC) and its recovery.

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Antifouling surfaces have attracted increasing interest in recent years due to their potential application in various fields. In this work, we report a loop polyzwitterionic coating that exhibits excellent resistance to protein adsorption. Triblock and diblock copolymers of 2-[(2-hydroxyethyl)disulfanyl]ethyl methacrylate) (HSEMA) and 2-(dimethylamino)ethyl methacrylate) (DMAEMA) were synthesized by atom-transferred radical polymerization, followed by betainization of the DMAEMA block with 1,3-propane sultone and reduction of the disulfide bond in HSEMA to yield a triblock copolymer comprising a zwitterionic poly(sulfobetaine methacrylate) (PSBMA) midblock and poly(2-sulfanylethyl methacrylate) (PSEMA) terminal blocks as well as its diblock analogue that was of the same composition as the former and half the chain length.

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Excessive NOD-like receptor thermal protein domain associated protein 3 (NLRP3) inflammasome activation has an important function in the pathogenesis of Sjögren's syndrome (SS). Increased and dysfunctional myeloid-derived suppressor cells (MDSCs) promoted SS. However, NLRP3 inflammasome activation of MDSCs in SS and its regulated components are unclear.

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