Risk factors of immune-related endocrine toxicities in non-small cell lung cancer patients treated with pembrolizumab and its impact on patient outcomes: a multicenter retrospective study.

Background: Pembrolizumab has been approved as a first-line treatment for non-small cell lung cancer (NSCLC) patients. However, a percentage of patients discontinue immunotherapy due to immune-related adverse events (irAE). Among these events, immune-related endocrine toxicities (E-irAE) represents the most common form, though their etiology, risk factors, and impact on patient outcomes remain poorly understood.

Evaluation of Prognostic Implication of Serum Mixed Lineage Kinase Domain-Like Protein in Acute Primary Supratentorial Intracerebral Hemorrhage: A Multicenter Prospective Cohort Study.

Objective: Mixed lineage kinase domain-like protein (MLKL) is a key component of necroptosis. Here, serum MLKL levels were measured with the intent to assess its prognostic significance in acute intracerebral hemorrhage (ICH).

Methods: A collective of 161 patients with acute primary supratentorial ICH and 73 controls were enlisted in this multicenter prospective cohort study.

Prognostic value of tumor deposits and positive lymph nodes in colorectal cancer surgery: improved staging for long-term prognosis.

Background: To evaluate the prognostic value of the presence and number of tumor deposits (TDs) and the combination of TDs and number of positive lymph nodes (PLNs) in patients undergoing colorectal cancer (CRC) surgery, and to modify N staging.

Method: The clinical data of 1470 patients with stage I-IV CRC who underwent surgery in Wuhan Union Hospital from February 2014 to May 2018 were collected. The optimal cutoff value for TD + PLNs was obtained using X-tile software, and patients were regrouped accordingly.

Optimizing Triple-Negative Breast Cancer Therapy via Ultrasound-Enhanced Piezocatalysis for Targeted Chemodrug Release.

Introduction: Triple-negative breast cancer (TNBC) is known for its high malignancy, limited clinical treatment options, and poor chemotherapy outcomes. Although some advancements have been made using nanotechnology-based chemotherapy for TNBC treatment, the controlled and on-demand release of chemotherapeutic drugs at the tumor site remains a challenge.

Methods: We manufactured DOX/BaTiO@cRGD-Lip (DBRL) nanoparticles as an ultrasound (US)-controlled release platform targeting the delivery of Doxorubicin (DOX) for TNBC treatment.

Precise engineering of gene expression by editing plasticity.

Background: Identifying transcriptional cis-regulatory elements (CREs) and understanding their role in gene expression are essential for the precise manipulation of gene expression and associated phenotypes. This knowledge is fundamental for advancing genetic engineering and improving crop traits.

Results: We here demonstrate that CREs can be accurately predicted and utilized to precisely regulate gene expression beyond the range of natural variation.

Ruthenium(II) polypyridyl complexes inhibit tumor growth through stimulating immune system to increase CD8 T cell.

In this work, we have carefully designed and synthesized two Ru(II) metal complexes: [Ru(phen)(HMPIP)](PF) (6a, where phen = 1,10-phenanthroline, HMPIP = 2-(2-hydroxy-3-methylphenyl-1H-imidazo[4,5-f][1,10]phenanthroline) and [Ru(bpy)(HMPIP)](PF) (6b, where bpy = 2,2'-bipyridine). Using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) to explore the cytotoxicity of 6a and 6b towards HepG2, B16, A549, SGC-7901, HCT116 and non-cancer LO2. The complexes exhibited cytotoxicity activity against HepG2 cells.

Activation of Sirt6 by icariside Ⅱ alleviates depressive behaviors in mice with poststroke depression by modulating microbiota-gut-brain axis.

Background: Sirt6-mediated gut microbiota plays a vital role in poststroke depression (PSD). Icariside Ⅱ (ICS Ⅱ) is a naturally-occurring neuroprotectant with Sirt6 induction potency. However, it is unknown whether ICS Ⅱ protects against PSD through modulation of gut microbiota.

MOF-KAN: Kolmogorov-Arnold Networks for Digital Discovery of Metal-Organic Frameworks.

Digital discovery of functional materials, such as metal-organic frameworks (MOFs), entails accurate and data-efficient approaches to navigate complex chemical and structural space. Based on an innovative deep learning approach, namely, Kolmogorov-Arnold Networks (KANs), we introduce MOF-KAN, a state-of-the-art architecture as the first application of KANs to digital discovery of MOFs. Through meticulous fine-tuning of network architecture, we demonstrate that MOF-KAN outperforms standard multilayer perceptrons (MLPs) in predicting diverse properties for MOFs, including gas separation, electronic band gap, and thermal expansion.

Usefulness of Serum NOX4 as a Potential Biomarker to Predict Early Neurological Deterioration and Poor Outcome of Spontaneous Intracerebral Hemorrhage: A Prospective Observational Study.

Background: NADPH oxidase 4 (NOX4) may play a critical role for inducing oxidative stress and inflammation after spontaneous intracerebral hemorrhage (sICH). This study was performed to assess associations of serum NOX4 levels with sICH severity, early neurological deterioration (END) and neurological outcomes.

Methods: In this prospective cohort study, serum of 161 sICH patients and 161 controls were collected for quantifying NOX4 levels.

Virtual nursing's effect on ED efficiency and quality of care.

Importance: Nursing shortages lead to longer emergency department (ED) wait times and incomplete documentation. US health systems are rapidly implementing virtual nursing, a new care delivery model, to improve care and alleviate nursing burden by providing nursing care and expertise via telehealth.

Objective: To evaluate the association of using virtual nursing for patients admitted via the ED with quality outcomes, namely, wait time, admission assessment duration, documentation completeness, and number of interruptions.

Renewable chitin-derived hard carbon as a free-standing anode for sodium-ion batteries.

A renewable strategy has been investigated to controllably synthesize hard carbon from biomass chitin. The obtained materials exhibit network-like porous structures with satisfactory N-doping contents, and realize remarkable initial coulombic efficiencies, cycling stabilities and rate capabilities as free-standing anodes for sodium-ion batteries.

phycocyanin subunit Ns-α and Ns-β improve antioxidative capacity ROS-related regulation.

Oxidative stress and damage to macromolecules due to free radicals such as reactive oxygen species (ROS) are commonly considered factors that can impair health. This study investigated the potential antioxidant properties of of two subunit proteins associated with the pigment-protein complex phycocyanin derived from (Gexianmi). Bacterial expression vectors were separately constructed to induce the two engineering subunit proteins, Ns-α and Ns-β.

Exploring Technology Integration in Health and Safety Routines in a Shanghai Kindergarten.

: Digital technology is increasingly being used in early childhood education; however, there is a significant gap in understanding how these technologies are practiced in health and safety routines. : This study aims to understand the role of technologies in daily health and safety checks and identify the issues arising from their use in a Shanghai kindergarten. : A qualitative approach was employed; the study involved video analysis and semi-structured interviews with 8 teachers, 18 parents, 11 children, and 3 principals from a leading kindergarten in Shanghai.

Association of serum galectin3 levels with six-month functional outcome of severe traumatic brain injury and the mediation effect of acute lung injury: A two-center prospective cohort study.

Background: Severe traumatic brain injury (sTBI) is frequently complicated with acute lung injury (ALI). Galectin3 poses a pivotal role in acute brain injury and non-traumatic ALI. Here, serum galectin3 was quantified with an intent to unravel its prognostic significance and mediation effects of ALI in humans with sTBI.

Regulatory role of S1P and its receptors in sepsis-induced liver injury.

As an immune and metabolic organ, the liver affects the progression and prognosis of sepsis. Despite the severe adverse effects of sepsis liver injury on the body, treatment options remain limited. Sphingosine-1-phosphate (S1P) is a widely distributed lipid signaling molecule that binds to five sphingosine-1-phosphate receptors (S1PR) to regulate downstream signaling pathways involved in the pathophysiological processes of sepsis, including endothelial permeability, cytokine release, and vascular tone.

ITGA5 synovial fibroblasts orchestrate proinflammatory niche formation by remodelling the local immune microenvironment in rheumatoid arthritis.

Objectives: To investigate the phenotypic heterogeneity of tissue-resident synovial fibroblasts and their role in inflammatory response in rheumatoid arthritis (RA).

Methods: We used single-cell and spatial transcriptomics to profile synovial cells and spatial gene expressions of synovial tissues to identify phenotypic changes in patients with osteoarthritis, RA in sustained remission and active state. Immunohistology, multiplex immunofluorescence and flow cytometry were used to identify synovial fibroblasts subsets.

Computational Screening Guiding the Development of a Covalent-Organic Framework-Based Gas Sensor for Early Detection of Lithium-Ion Battery Electrolyte Leakage.

This study presents a computationally guided approach for selecting covalent organic frameworks (COFs) for the selective detection of the trace ethylene carbonate (EC) vapor, a key indicator of electrolyte leakage from lithium-ion batteries (LIBs). High-throughput screening, employing grand canonical Monte Carlo (GCMC) simulation complemented by density functional theory (DFT) calculations, was used to identify potential COF candidates from the CURATED COF database. Among the screened materials, an imine COF functionalized with quaternary ammonium (QA) groups, named COF-QA-4, exhibited a high adsorption capacity (5.

Curcumol promotes immune cell invasion and inhibits angiogenesis in colon cancer by decreasing IGF2BP3 expression.

The study investigates the potential mechanisms by which curcumol exerts colon anti-cancer effects through angiogenesis and immune infiltration. Using The Cancer Genome Atlas (TCGA) database, we found abnormal levels of IGF2BP3 in both paraneoplastic and colon cancer tissues. Firstly, in vivo experiments were conducted to detect the colon anti-cancer and pro-apoptotic effects of curcumol.

Diatomite-Based Hybrid Electrolyte for Improving Reversibility of Cathode/Anode Interface Reaction in Zn-MnO Batteries.

The cyclic stability of aqueous zinc-manganese batteries (ZMBs) is greatly restricted by the side reaction of the anode and the irreversibility of the cathode. In this work, a solid-liquid hybrid electrolyte mixing by traditional ZnSO-based electrolyte and diatomite (denoted as Dtm) is proposed that exhibits good compatibility and reversibility in both the anode interface and the cathode interface. The abundant hydroxyl groups at the anode interface disturb the hydrogen bond network of water molecule, which weakens the corrosion of the active water to Zn anode.

The Gut Microbiota-Xanthurenic Acid-Aromatic Hydrocarbon Receptor Axis Mediates the Anticolitic Effects of Trilobatin.

Current treatments for ulcerative colitis (UC) remain limited, highlighting the need for novel therapeutic strategies. Trilobatin (TLB), a naturally derived food additive, exhibits potential anti-inflammatory properties. In this study, a dextran sulfate sodium (DSS)-induced animal model is used to investigate the effects of TLB on UC.

Magnetic field-mediated oxidative modification of myoglobin: One effective method for improving the gel properties of myofibrillar protein.

This study employed a magnetic field to investigate the impact of myoglobin (Mb) oxidation (0-20 mmol/L HO) on the gel properties of myofibrillar protein (MP). The results indicated that magnetic field could further facilitate the rearrangement of the Mb structure, resulting in the transfer of its internal reactive groups to the external environment. This contributed to hydration and cross-linking between MP.

Immunogenic dying cells elicit potent anti-tumor T cell immunity against lung metastasis and tumorigenesis.

Purpose: Immune checkpoint blockades (ICBs) are promising, however they do not fit all types of tumor, such as those lack of tumor antigens. Induction of potent anti-tumor T cell immunity is critical for cancer therapy. In this study, we investigated the efficacy of immunotherapy via the immunogenic cell death (ICD) dying tumor cells in mouse models of lung metastasis and tumorigenesis.

Human urinary occurrence of thiourea vulcanization accelerators and their human exposure.

Thiourea vulcanization accelerators (TVAs) have been detected in various household dust samples, indicating their widespread human exposure. Until now, the occurrence of TVAs in human urine, a suitable matrix for assessing human exposure, has remained unknown. The present study comprehensively examined eight kinds of TVAs in urine samples (n = 277) from participants living in Taizhou, China.

Targeting MXD1 sensitises pancreatic cancer to trametinib.

Background: The resistance of pancreatic ductal adenocarcinoma (PDAC) to trametinib therapy limits its clinical use. However, the molecular mechanisms underlying trametinib resistance in PDAC remain unclear.

Objective: We aimed to illustrate the mechanisms of resistance to trametinib in PDAC and identify trametinib resistance-associated druggable targets, thus improving the treatment efficacy of trametinib-resistant PDAC.