Publications by authors named "Xiaoyu Wei"

As a common clinical manifestation, muscle weakness is prevalent in people with mobility disorders. Further studies of muscle weakness have found that patients with muscle weakness present with persistent muscle inflammation, loss of muscle fibers, fat infiltration, and interstitial fibrosis. Therefore, we propose the concept of muscle microenvironment homeostasis, which explains the abnormal pathological changes in muscles through the imbalance of muscle microenvironment homeostasis.

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Soluble sugars are not only an important contributor to fruit quality, but also serve as the osmotic regulators in response to abiotic stresses. Early drought stress promotes sugar accumulation, while specific sugar transporters govern the cellular distribution of the sugars. Here, we show that apple plantlets accumulate soluble sugars in leaf tissues under drought stress.

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It has been claimed that microRNA 503-5p (miR-503-5p) is the key to the future diagnosis and treatment of cardiac hemangioma (CH), but the relationship between the two has not been fully validated. In this study, we analyzed the effect of miR-503-5p targeting type IA bone morphogenetic protein receptor (BMPR1A) on CH to inform future diagnosis and treatment of CH. First, miR-503-5p and BMPR1A abnormal expression sequences (vectors) were transfected into human hemangioma-derived endothelial cells (HemECs) and human umbilical vein endothelial cells (HUVECs) to observe alterations in cell biological behavior, adhesion, and epithelial mesenchymal transition (EMT).

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Browning is a pervasive problem in horticultural products, substantially diminishing the appearance, flavor and nutritional value of fruit, including important fruits like apple (Malus × domestica Borkh.). In this study, we compared the physiological characteristics of the browning-resistant line 'Rb-18' with the susceptible variety 'Fuji' and found that the polyphenol oxidase (PPO) enzyme activity and phenolic content of Rb-18 were significantly lower than those in Fuji.

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  • Mutations in the RNA helicase DDX3X, linked to cancer and neurodevelopmental disorders, disrupt its normal RNA unwinding and translation functions.
  • The study finds that certain DDX3X mutants form unique hollow condensates in cells, which are associated with reduced ATPase and RNA release activities due to blockages in their catalytic processes.
  • These condensates also trap wild-type DDX3X/DDX3Y and other important proteins, with wild-type DDX3X promoting more dynamic interactions than its Y-linked counterpart DDX3Y, shedding light on how these variations may influence disease susceptibility based on sex.
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The identification of both autophagy-related material degradation and unconventional secretion has paved the way for significant breakthroughs linking autophagy to a plethora of physiological processes and disease conditions. However, the mechanisms that coordinate these two pathways remain elusive. Here, we demonstrate that a switch from the lysosomal degradation to a secretory autophagy pathway is governed by protein tyrosine phosphatase 1B (PTP1B, encoded by PTPN1).

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Purpose To explore the role of cardiac MRI feature tracking (FT) and T1 mapping in predicting sustained ventricular arrhythmias (VA) in patients with arrhythmogenic right ventricular cardiomyopathy (ARVC) and to investigate their possible incremental value beyond ARVC risk score. Materials and Methods The retrospective study analyzed 91 patients with ARVC (median age, 36 years [IQR, 27-50 years]; 60 male, 31 female) who underwent cardiac MRI examinations between November 2010 and March 2022. The primary end point was the first occurrence of sustained VA after cardiac MRI to first VA, with censoring of patients who were alive without VA at last follow-up.

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Organic acids are major determinants of fruit flavor and a primary focus of fruit crop breeding. The accumulation of organic acids is determined by their synthesis, degradation, and transport, all of which are manipulated by sophisticated genetic mechanisms. Constant exploration of the genetic basis of organic acid accumulation, especially through linkage analysis, association analysis, and evolutionary analysis, have identified numerous loci in recent decades.

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Endometriosis is a multifactorial gynecological disease, with angiogenesis as a key hallmark. The role of exosomal microRNAs (miRNAs) in endometriosis is not well understood. This study investigates differentially expressed exosomal miRNAs linked to angiogenesis in endometriosis, clarifies their molecular mechanisms, and identifies potential targets.

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Purpose: Attention, a complex cognitive process, is linked to the functional activities of the brain's dorsal attention network (DAN) and default network (DN). This study aimed to investigate the feasibility, safety, and blinding efficacy of a transcranial direct current stimulation (tDCS) paradigm designed to increase the excitability of the DAN while inhibiting the DN (DAN+/DN-tDCS) on attention function in healthy young adults.

Methods: In this randomized controlled experiment, participants were assigned to either the DAN+/DN-tDCS group or the sham group.

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Spatial transcriptomics enables a single-cell resolution view of gene expression patterns in tissues, providing insight into their biological functions. However, applying this approach to the skin presents inherent challenges. Here, we present a protocol for preparing mammalian skin samples encompassing hair follicles for spatial transcriptomics.

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Hydrogen peroxide (HO) production driven by solar energy has received enormous attention due to its high efficiency, low cost, and environmental friendliness characteristics. Searching for new photocatalytic materials for HO production is one of the most important targets. In this work, a new three-dimensional (3D) uranyl-organic framework material was constructed with mixed ligands via a solvothermal reaction and used for photocatalytic HO production.

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  • * In a study involving 23 bladder cancer patients and 9 non-cancerous subjects, urine samples were analyzed for microbiota and metabolites before and after surgery, revealing significant differences in cytokine levels and metabolic profiles.
  • * The study found elevated cytokines and unique microbiome characteristics in bladder cancer patients; after tumor removal, some changes persisted, while a specific biomarker panel showed promising diagnostic accuracy with high sensitivity and specificity.
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Hydrophilic coating can prevent surface from fogging but its application is limited by low mechanical performance. In this study, a hydrophilic coating was prepared by crosslinking the Si-doped carbonized polymer dot (Si-CPD) with 3-glycidyloxypropyltrimethoxysilane (GPTMS) and ethylene oxide (EO). The hydrophilic coating can be used as robust hydrophilic anti-fogging coating.

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  • - Malic acid plays a crucial role in determining the flavor of apples, with variations like the A/G SNP in the MdMa1 gene affecting its content, but other factors also influence malic acid levels among apple varieties.
  • - A study of the F1 generation from the 'Honeycrisp' and 'Qinguan' apple varieties identified a significant locus, Ma7, on chromosome 13 that affects malic acid content, with the MDH1 gene being a key player in this process.
  • - Genetic modifications in the MDH1 promoter influence its expression and malic acid levels, with the transcription factor MdbHLH74 enhancing MDH1 expression in certain apple genotypes, indicating a complex relationship between
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Acidity is a key factor controlling fruit flavor and quality. In a previous study, combined transcriptome and methylation analyses identified a P3A-type ATPase from apple (Malus domestica), MdMa11, which regulates vacuolar pH when expressed in Nicotiana benthamiana leaves. In this study, the role of MdMa11 in controlling fruit acidity was verified in apple calli, fruits, and plantlets.

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Small molecule photosensitizers for combined in vivo tailored cancer diagnostics and photodynamic/photothermal therapy are desperately needed. Monoamine oxidase A (MAO-A)-activated therapeutic and diagnostic compounds provide great selectivity because MAO-A can be employed as a biomarker for associated Tumors. In order to screen photosensitizers with photodynamic therapeutic potential, we have created a range of near-infrared fluorescent molecules in this work by combining dihydroxanthene parent with various heterocyclic fluorescent dyes.

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  • This study explores how sugars and acids contribute to the flavor and quality of fleshy fruits, particularly apples during their development.
  • Researchers used advanced techniques like ATAC-seq and RNA-seq to analyze genome-wide chromatin accessibility, leading to the creation of a transcriptional regulatory network related to sugar and acid accumulation.
  • The findings identify key transcription factors that regulate the metabolism of sugars and acids in apples, which could help improve apple quality in the future.
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Background: The structural diversity of extracellular polymeric substances produced by microorganisms is attracting particular attention. Poly-gamma-glutamic acid (γ-PGA) is a widely studied extracellular polymeric substance from Bacillus species. The function of γ-PGA varies with its molecular weight (Mw).

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Exposure to PM, a harmful type of air pollution, has been associated with compromised male reproductive health; however, it remains unclear whether such exposure can elicit transgenerational effects on male fertility. Here, we aim to examine the effect of paternal exposure to real-world PM on the reproductive health of male offspring. We have observed that paternal exposure to real-world PM can lead to transgenerational primary hypogonadism in a sex-selective manner, and we have also confirmed this phenotype by using an external model.

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  • The study explores how liver cells in mammals coordinate their responses during normal function and when faced with challenges, addressing a significant knowledge gap in understanding liver-related diseases.
  • Researchers used advanced techniques, including Stereo-seq and single-cell transcriptomics, to create a detailed atlas of mouse liver homeostasis and regeneration, analyzing a massive dataset of over 473,000 cells.
  • Key findings include identifying the transcriptional cofactor TBL1XR1, which plays a crucial role in linking inflammation to liver cell proliferation, paving the way for future studies on organ physiology and dysfunction.
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Background: Physical activity (PA) is widely recommended for preventing and combating obesity, but the most effective PA pattern for treating obesity remains unclear. Cardiometabolic index (CMI), derived from waist height ratio and triglycerides to high-density lipoprotein-cholesterol ratio, is a novel indicator for evaluating obesity. However, the relationship between different PA patterns and CMI remains unelucidated.

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Background: A-to-I RNA editing is an abundant post-transcriptional modification event in hepatocellular carcinoma (HCC). Evidence suggests that adenosine deaminases acting on RNA 1 (ADAR1) correlates to oxidative stress that is a crucial factor of HCC pathogenesis. The present study investigated the effect of ADAR1 on survival and oxidative stress of HCC, and underlying mechanisms.

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Single-cell RNA sequencing (scRNA-seq) is a powerful tool for studying transcriptomics. Here, we present an optimized protocol for dissociating human scalp tissue and acquiring high-quality single-cell suspension for scRNA-seq to study transcriptomics of human hair follicles. We describe steps for human scalp tissue cleaning, subcutaneous fat removal, mechanical mincing, and enzymatic digestion.

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Background: Cardiovascular disease is a major complication of diabetes mellitus (DM). Type-2 DM (T2DM) is associated with an increased risk of cardiovascular events and mortality, while serum biomarkers may facilitate the prediction of these outcomes. Early differential diagnosis of T2DM complicated with acute coronary syndrome (ACS) plays an important role in controlling disease progression and improving safety.

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Synopsis of recent research by authors named "Xiaoyu Wei"

  • XiaoYu Wei's recent research spans diverse fields including cardiac imaging in arrhythmogenic cardiomyopathy, genetic mechanisms of organic acid accumulation in fruits, and the role of exosomal microRNAs in endometriosis.* -
  • A significant focus of Wei's investigations includes the predictive capabilities of cardiac MRI features and genetic determinants on health conditions, such as the risk of ventricular arrhythmias and fruit flavor quality.* -
  • Wei has also contributed to understanding biological processes at the molecular level, such as angiogenesis in endometriosis and extracellular polymeric substance synthesis in bacteria, indicating a strong emphasis on translational applications in medicine and agriculture.*