Background: Breast cancer, a highly prevalent global cancer, poses significant challenges, especially in advanced stages. Prognostic models are crucial to enhance patient outcomes. Tertiary lymphoid structures (TLS) within the tumor microenvironment have been associated with better prognostic outcomes.
View Article and Find Full Text PDFBackground: Digital education for outpatient patients with atrial fibrillation (AF) has gradually increased. However, research on digital education for patients undergoing atrial fibrillation catheter ablation (AFCA) is limited.
Objective: This study aimed to develop a novel digital animation-based multistage education system and evaluate its quality-of-life benefits for patients with AFCA.
Introduction: Histone acetylation modifications can regulate gene transcription and play crucial roles in multiple tumorigeneses processes. YEATS domain proteins are one important type of acetylation readers. We have found significant mutations and copy number amplifications of YEATS domain containing 2 (YEATS2) gene in esophageal squamous cell carcinoma (ESCC) through whole genome sequencing (WGS).
View Article and Find Full Text PDFBackground: The emergence of tick-borne pathogens poses a serious threat to both human and animal health. There remains controversy about virome diversity in relation to tick genus and ecogeographical factors.
Results: We conducted the meta‑transcriptomic sequencing of 155 pools of ticks encompassing 7 species of 3 genera collected from diverse geographical fauna of Ningxia Province, China.
Demyelination is a common feature of numerous neurological disorders including multiple sclerosis and leukodystrophies. Although myelin can be regenerated spontaneously following injury, this process is often inadequate, potentially resulting in neurodegeneration and exacerbating neurological dysfunction. Several drugs aimed at promoting the differentiation of oligodendrocyte precursor cells (OPCs) have yielded unsatisfactory clinical effects.
View Article and Find Full Text PDFJ Phys Condens Matter
March 2025
COhydrates show promising application in COsequestration, as well as natural gas recovering from hydrate-bearing sediments, in which the stability of COhydrates plays a vital role in these practical applications. Here, we report the thermal dissociation and cage transformations in polycrystalline COhydrates via high-throughput molecular dynamics simulations and machine learning (ML). It is revealed that the melting points of polycrystalline COhydrates (PCO2H) are dictated by the microstructural cages, in which the 5, 56and 456cages predominate.
View Article and Find Full Text PDFBackground: Post-traumatic stress disorder (PTSD) is a potentially disabling condition that can lead to long-term impairments, with a significant proportion of adolescents being affected by trauma. Studies have suggested that trauma-focused cognitive behavioral therapy (TF-CBT) is an effective treatment for PTSD in adolescents, however, little is known about the relative advantages of different mind-body interventions. The network meta-analysis aims to evaluate and compare the efficacy of various mind-body interventions in alleviating PTSD symptoms in adolescents.
View Article and Find Full Text PDFEnvironmental factors can influence ecological networks, but these effects are poorly understood in the realm of the phylogeny of host-parasitoid interactions. Especially, we lack a comprehensive understanding of the ways that biotic factors, including plant species richness, overall community phylogenetic and functional composition of consumers, and abiotic factors such as microclimate, determine host-parasitoid network structure and host-parasitoid community dynamics. To address this, we leveraged a 5-year dataset of trap-nesting bees and wasps and their parasitoids collected in a highly controlled, large-scale subtropical tree biodiversity experiment.
View Article and Find Full Text PDFBackground: Oral microbiome dysbiosis is an important risk factor affecting the occurrence and progression of coronary artery disease (CAD). However, the dysbiosis on the tongue in patients with CAD is still unclear, and whether the oral alteration caused by these disorders can be identified by other tools for CAD diagnosis needs to be further explored. Hyperspectral imaging (HSI) is characterized as high spectral resolution, broad spectral range, and superior spatial resolution.
View Article and Find Full Text PDFFor electronics to be wearable, contactless charging and overall deformability are necessary pre-conditions. However, the current heterogeneous integration based on different active materials and separate manufacturing often leads to mechanical mismatch. Here, we report an ultrastretchable all-in-one integrated MXene-based microsystem comprising wireless coils, micro-supercapacitors (MSCs) and strain sensors.
View Article and Find Full Text PDFHerein, the gold nanoclusters@three-dimensional (3D) porous ZrO hollow nanospheres (Au NCs@ZrO) with spatial confinement-enhanced electrochemiluminescence (SCE-ECL) were first prepared to fabricate a biosensing platform for the ultrasensitive detection of insulin-like growth factor 1 (IGF-1), which was associated with cardiovascular disease, malignant tumor, and neuropathic pain. Specifically, the confinement of Au NCs in a 3D microenvironment significantly boosted the optical radiation of excited Au NCs because the vibration of ligand molecules was restricted, and the recombination of holes and electrons of excited Au NCs was facilitated in the optical process for enhancing ECL efficiency, resulting in 5.1-fold stronger ECL efficiency than Au NCs.
View Article and Find Full Text PDFHerein, we developed the agmatine/6-aza-2-thiothymine templated gold nanoclusters (Agm/ATT-Au NCs) as a novel electrochemiluminescence (ECL) illuminant, which exhibited high ECL in the annihilation path via the newly defined urface harge edistribution-nduced ECL nhancement (SCRIE). Impressively, the electrochemical redox reaction of Agm/ATT-Au NCs was enhanced owing to the boosted electron transfer kinetics of the illuminant by the positively charged Agm-triggered surface charge redistribution of ATT-Au NCs, resulting in an ∼110-fold higher ECL signal of Agm/ATT-Au NCs than ATT-Au NCs. This work digs deep into the electrogenerated process of the annihilation mechanism to direct the rational design of an efficient illuminant.
View Article and Find Full Text PDFBackground And Objective: Cloud-based Deep Learning as a Service (DLaaS) has transformed biomedicine by enabling healthcare systems to harness the power of deep learning for biomedical data analysis. However, privacy concerns emerge when sensitive user data must be transmitted to untrusted cloud servers. Existing privacy-preserving solutions are hindered by significant latency issues, stemming from the computational complexity of inner product operations in convolutional layers and the high communication costs of evaluating nonlinear activation functions.
View Article and Find Full Text PDFBackground: Ceramide, a key molecule in sphingolipid metabolism, is recognized as a standalone predictor of long-term major adverse cardiac events (MACE). We explore if integrating the global registry of acute coronary events (GRACE) score with the ceramide risk score (ceramide test 1, CERT1) improves MACE prediction in patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI).
Methods: This cohort study included 210 participants with ACS undergoing PCI.
Metal-free photocatalysts derived from earth-abundant elements have drawn significant attention owing to their ample supply for potential large-scale applications. However, it is still challenging to achieve highly efficient photocatalytic performance owing to their sluggish charge separation and lack of active catalytic sites. Herein, we designed and constructed a series of covalently bonded organic semiconductors to enhance water splitting and phenol degradation.
View Article and Find Full Text PDFCrop plant microbiomes are increasingly seen as important in plant nutrition and health, and a key to maintaining food productivity. Currently, little is known of the temporal changes that occur in the wheat rhizosphere microbiome as the plant develops, and how this varies among different sites. We used a pot-based mesocosm experiment with the same modern wheat cultivar grown in eight soils from across the North China Plain, a major wheat producing area.
View Article and Find Full Text PDFBackground: Clinical studies on atrial fibrillation (AF) recurrence after catheter ablation in patients diagnosed with patent foramen ovale (PFO) and paroxysmal AF (PAF) are scarce. Here, we aimed to develop a nomogram model utilizing multimodal data for the risk stratification of AF recurrence following catheter ablation in individuals diagnosed with PFO and new-onset PAF.
Methods: Patients with PFO and PAF who underwent catheter ablation at the Renmin Hospital of Wuhan University from January 2018 to June 2020 were consecutively enrolled.
Random lasers (RLs) with a simple structure and low-cost properties have been recognized as an ideal analytical platform and are still challenging for liquid detecting, remaining beset for low sensitivity, complicated operation, and large analyte consumption. Here, inspired by a microfluidic sensor, a microtubule structured random laser for multifunctional sensing is demonstrated. The random laser is achieved resorting to a curly PMMA film with gain and scatterers embedded in it.
View Article and Find Full Text PDFThe zeta inhibitory peptide (ZIP) interferes with memory maintenance and long-term potentiation (LTP) when administered to mice. However, mice lacking its putative target, protein kinase PKMζ, exhibit normal learning and memory as well as LTP, making the mechanism of ZIP unclear. Here we show that ZIP disrupts LTP by removing surface AMPA receptors through its cationic charge alone.
View Article and Find Full Text PDFPre-mRNA 3' processing is an integral step in mRNA biogenesis. However, where this process occurs in the nucleus remains unknown. Here, we demonstrate that nuclear speckles (NSs), membraneless organelles enriched with splicing factors, are major sites for pre-mRNA 3' processing in human cells.
View Article and Find Full Text PDFMegachile sculpturalis Smith, 1853 native to East Asia, is an important solitary bee species that has invaded both Europe and the United States. This study provides the first chromosome-level genome assembly of M. sculpturalis using a combination of Nanopore long reads, Illumina short reads, and Hi-C data.
View Article and Find Full Text PDFBackground: Oral microenvironmental disorders are associated with an increased risk of heart failure with preserved ejection fraction (HFpEF). Hyperspectral imaging (HSI) technology enables the detection of substances that are visually indistinguishable to the human eye, providing a noninvasive approach with extensive applications in medical diagnostics.
Objective: The objective of this study is to develop and validate a digital, noninvasive oral diagnostic model for patients with HFpEF using HSI combined with various machine learning algorithms.
Despite significant advances in targeted therapies and immunotherapies, non-small cell lung cancer (NSCLC) continues to present a global health challenge, with a modest five-year survival rate of 28 %, largely due to the emergence of treatment-resistant and metastatic tumors. In response, we synthesized a novel bioactive compound, ethyl 6-chlorocoumarin-3-carboxylyl L-theanine (TClC), which significantly inhibited NSCLC growth, epithelial mesenchymal transition (EMT), migration, and invasion and tumor growth and metastasis without inducing toxicity. TClC disrupts autocrine loops that promote tumor progression, particularly in stem-like CD133-positive NSCLC (CD133+ LC) cells, which are pivotal in tumor metastasis.
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