[Mechanism of Huoxue Dingxuan Capsules on autophagy in vascular endothelial cells based on "crosstalk" of Bcl-2 and mTOR protein].

This paper investigated the mechanism of Huoxue Dingxuan Capsules(HXDX) on autophagy in vascular endothelial cells based on the "crosstalk" of Bcl-2 and mTOR protein. bEnd.3 cells were divided into a blank control group, a model group, and an HXDX group.

Greater neural pattern similarity to the native language is associated with better novel word learning.

Introduction: Previous neuroimaging studies on bilingualism revealed that individuals tend to apply their native-language (L1) neural strategies to second language (L2) learning and processing. Nevertheless, it is still unclear how the utilization of the L1 neural strategies affects visual word learning in a new language.

Methods: To address this question, the present study scanned native Chinese speakers while performing implicit reading tasks before 9-day form-meaning learning in Experiment 1 and before 12-day comprehensive word learning in Experiment 2.

Combined systemic immune-inflammatory index and prognostic nutritional index predicts the efficacy and prognosis of ES-SCLC patients receiving PD-L1 inhibitors combined with first-line chemotherapy.

Background: There is a strong association between inflammation and the formation, progression, and metastasis of malignant tumors, according to earlier studies. Some composite inflammation-nutritional indicators, such as the systemic immune-inflammation index (SII) and the prognostic nutritional index (PNI), have a certain predictive effect on the prognosis of patients with small cell lung cancer (SCLC). However, the relationship between these indicators and the efficacy of immunotherapy in SCLC patients is still not well understood.

Dust mite antigens endow dendritic cells with the capacity to induce a Th2 response by regulating their methylation profiles.

Background: It is well-known that Dendritic cells (DCs) are essential in the development of airway Th2 polarization and airway allergy (AA). The underlying mechanism is still not fully understood. The objective of this study is to examine the role of methyltransferase-like protein-5 (Mettl5), a methyltransferase involved in N6-methyladenosine (m6A) methylation, in altering DC's properties to facilitate the development of Th2 polarization and AA.

, a Small Family of ABA Up-Regulated EAR Motif-Containing Proteins Regulate ABA Responses in Arabidopsis.

The abscisic acid (ABA) signaling pathway is crucial for regulating downstream ABA-responsive genes, which influence plant responses to ABA and abiotic stresses. However, many ABA-responsive genes remain poorly characterized. This study reports on the identification and characterization of ABA up-regulated EAR motif-containing proteins (), a novel family of EAR motif-containing proteins in .

[Mechanism of electroacupuncture at "Zusanli" (ST36) in improving cardiac function in mice with chronic heart failure].

Objectives: To observe the effect of electroacupuncture (EA) at "Zusanli" (ST36) on improving cardiac function in mice with chronic heart failure (CHF), so as to explore the mechanism of its regulation on the autonomic nervous system.

Methods: Eighteen C57BL/6J mice were randomly divided into sham-surgery, model, and EA groups, with 6 mice in each group. The model of myocardial ischemia followed by CHF was induced by ligation of the anterior descending branch of the left coronary artery.

Generation of a BEST1 Pr-EGFP reporter human embryonic stem cell line via CRISPR/Cas9 editing.

The retinal pigment epithelium (RPE) cell, located between the neural retina and choriocapillaris, is vital for retinal maintenance and photoreceptor function. Human embryonic stem cells (hESCs) provide a limitless source of RPE cells for transplantation. Using CRISPR/Cas9, we inserted a fusion of the BEST1 promoter (an RPE-specific marker) and the EGFP gene into the AAVS1 locus to track differentiation in hESC-induced RPE (hESC-iRPE).

Preparation of eco-friendly multifunctional lyocell fabric with flame retardant, antibacterial and UV resistant using glucose-derived NP compounds.

A biomass-based finishing agent (ArCP) rich in nitrogen and phosphorus was synthesized from glucose, arginine and phosphorous acid, which was then used for lyocell fabrics to prepare flame retardant, antibacterial and UV resistant properties lyocell fabrics (ArCP-lyocell). The elemental composition, surface morphology, combustion performance, antibacterial and UV resistant properties for the lyocell fabrics before and after modification were investigated. ArCP-lyocell fabrics showed excellent self-extinguishing properties with a limiting oxygen index (LOI) of 35.

Molecular sociology of virus-induced cellular condensates supporting reovirus assembly and replication.

Virus-induced cellular condensates, or viral factories, are poorly understood high-density phases where replication of many viruses occurs. Here, by cryogenic electron tomography (cryoET) of focused ion beam (FIB) milling-produced lamellae of mammalian reovirus (MRV)-infected cells, we visualized the molecular organization and interplay (i.e.

Diagnosis of acute Q fever using targeted next‑generation sequencing: A case report.

Acute Q fever, caused by , is a zoonotic infection presenting with non-specific symptoms such as high fever, severe headache and myalgia, making it challenging to diagnose. Traditional diagnostic methods often fall short due to their time-consuming nature and limited sensitivity. A 26-year-old male presented with severe headache, persistent high fever and nausea following a hiking trip.

Mechanism and Application of Chinese Herb Medicine in Treatment of Peripheral Nerve Injury.

Peripheral nerve injury (PNI) encompasses damage to nerves located outside the central nervous system, adversely affecting both motor and sensory functions. Although peripheral nerves possess an intrinsic capacity for self-repair, severe injuries frequently result in significant tissue loss and erroneous axonal junctions, thereby impeding complete recovery and potentially causing neuropathic pain. Various therapeutic strategies, including surgical interventions, biomaterials, and pharmacological agents, have been developed to enhance nerve repair processes.

Lignin-based flame retardants chelated with Fe: Facilitating the development of flame retardant, UV resistant and antibacterial properties polyvinyl alcohol composites.

To overcome the problems of inflammability, poor UV resistance and susceptible to bacterial growth of polyvinyl alcohol (PVA), a new lignin-based PVA composite (PVA/PLig-Fe) was prepared. Compared to PVA, the limiting oxygen index (LOI) of PVA/PLig-Fe was increased by 64.8 %.

Curcumin mitigates sodium fluoride toxicity in Caenorhabditis elegans.

Fluoride, a naturally occurring element found in water, soil, food, and atmospheric precipitation, can lead to fluorosis and various health issues when consumed excessively. However, the mechanism of fluorosis is still under investigation. This study utilizes Caenorhabditis elegans as a model organism to investigate the effects of fluoride exposure on biological systems and to explore the mechanisms by which curcumin mitigates fluoride-induced toxicity.

Prevention of Early Ventriculoperitoneal Shunt Infection: A Long-Term Experience from Peking Union Medical College Hospital.

Preventing the early shunt infection is critical for the success of ventriculoperitoneal shunt (VPS) operation. Our goal was to establish a standardized protocol to prevent early shunt infection. This was a single-center retrospective study.

Discerning Emittable from Extractable Chemicals Identified in Consumer Products by Suspect Screening GCxGC-TOFMS.

Characterization of chemicals in household products is important for understanding this potential source of chemical exposure. Increasingly, suspect screening and nontargeted analysis techniques are used to characterize as many chemical signatures as possible. Solids such as household products are most conveniently prepared using solvent extraction, revealing what chemicals are contained within the product matrix but providing no information about the potential of those chemicals to leave the matrix and cause actual exposure.

Neuronal TCF7L2 in Lateral Habenula Is Involved in Stress-Induced Depression.

Depression is a complex psychiatric disorder that has substantial implications for public health. The lateral habenula (LHb), a vital brain structure involved in mood regulation, and the N-methyl-D-aspartate receptor (NMDAR) within this structure are known to be associated with depressive behaviors. Recent research has identified transcription factor 7-like 2 (TCF7L2) as a crucial transcription factor in the Wnt signaling pathway, influencing diverse neuropsychiatric processes.

Preparation and Characteristics of Ball-Milled Blueberry Peel Particles and Their Application in Ice Cream.

Ice cream is popular but contains high amounts of saturated fats and few health-promoting ingredients. In the presence of xanthan gum (0.25%), blueberry peel particles prepared through ball-milling treatment (BMPs) were used to prepare ice cream containing camellia oil as a fat replacer.

Direct electrochemical N oxidation to nitrate on supportive Pt/CeO.

Here, we present the development of an efficient Pt/CeO catalyst for electrocatalytic N oxidation to nitrate. Characterization results indicate that highly dispersed Pt and oxygen vacancies from CeO nanocubes (NCs) exhibit strong interactions, which promote the N adsorption on the catalyst surface and suppress the competitive OER activity on oxygen vacancies, resulting in significantly enhanced e-NOR performance.

Environmental enrichment attenuates maternal separation-induced excessive hoarding behavior in adult female mice.

Background: Previous studies have demonstrated that early life stress (ELS) impacts hoarding behavior in adult humans. This study aimed to assess the potential mitigation by environmental enrichment on hoarding behavior in rodents caused by maternal separation, thereby providing insights into therapeutic strategies for hoarding disorder.

Methods: Newborn mice were randomly divided into four groups.

Performance analysis of polar-coded FSO systems using turbulence-oriented rotational probabilistic shaping.

Free-space optical (FSO) communications can provide high speed and large capacity, yet atmospheric turbulence poses a challenge. We propose a novel turbulence-oriented rotated probabilistic shaping (TRPS) scheme to achieve joint gains in coding, shaping, and signal space diversity for FSO systems. Our approach significantly enhances achievable rates in high signal-to-noise ratio (SNR) regions as turbulence intensity increases by optimizing probabilities and rotation angles.

Optimization of SHP2 allosteric inhibitors with novel tail heterocycles and their potential as antitumor therapeutics.

SHP2, a non-receptor protein tyrosine phosphatase involved in cancers, plays a pivotal role in numerous cellular signaling cascades, including the MAPK and PD-L1/PD-1 pathways. Although several SHP2 allosteric inhibitors have already entered clinical trials, none have been approved to date. Therefore, the development of new SHP2 allosteric inhibitors with improved efficacy is urgently required.

Case report: Metagenomic next-generation sequencing for the diagnosis of rare infection in a patient with immune thrombocytopenia.

Background: Nocardiosis poses a diagnostic challenge due to its rarity in clinical practice, non-specific clinical symptoms and imaging features, and the limitations of traditional detection methods. () is rarely detected in clinical samples. Metagenomic next-generation sequencing (mNGS) offers significant advantages over traditional methods for rapid and accurate diagnosis of infectious diseases, especially for rare pathogens.

Exploring Experiences and Perceptions of Stroke Survivors in Hospital-To-Home Transition Care: A Qualitative Systematic Review.

Aim: To integrate experiences and perceptions about stroke survivors during the transition from hospital-to-home care.

Data Sources: Seven databases, including PubMed, Embase, Cochrane Library, Ovid, Web of Science, EBSCO and MEDLINE, were searched comprehensively from inception to March 2024, including qualitative studies published in English.

Design: A qualitative systematic review.