Muscle-derived decellularised extracellular matrix improves functional recovery in a rat latissimus dorsi muscle defect model.

Purpose: Craniofacial maxillary injuries represent nearly 30% of all battlefield wounds, often involving volumetric muscle loss (VML). The physical loss of muscle results in functional deficits and cosmetic disfigurement. Although surgical solutions are limited, advances in biomaterials offer great promise for the restoration of form and function following VML.

Effects of transforming growth factor-beta (TGF-β1) on satellite cell activation and survival during oxidative stress.

The regulation of adult skeletal muscle repair and regeneration is largely due to the contribution of resident adult myogenic precursor cells called satellite cells. The events preceding their participation in muscle repair include activation (exit from quiescence), proliferation, and differentiation. This study examined the effects of transforming growth factor-beta (TGF-β1) on satellite cell activation, determined whether TGF-β1 could maintain quiescence in the presence of hepatocyte growth factor (HGF), and whether the regulation of satellite cell activation with TGF-β1 improves the ability of satellite cells to withstand oxidative stress.

Treatment of tourniquet-induced ischemia reperfusion injury with muscle progenitor cells.

Background: Acute ischemia reperfusion injury (IRI) results in muscle atrophy and functional loss. Although studies have shown that stem cells can improve muscle function in chronic ischemia caused by vascular diseases, none investigated whether stem cells can improve muscle function following acute IRI. The primary purpose of this study was to determine whether transplantation of muscle progenitor cells (MPCs) improves recovery of muscle function after tourniquet (TK) induced IRI.