Copper(II) quinoxolinol imidazolium complexes in catalytic oxidation of benzylic and heterocyclic alcohols.

A novel copper(II) quinoxolinol complex has been prepared using a condensation reaction based on previous studies. The copper(II) quinoxolinol salen complex has been applied as a catalyst using -butyl hydroperoxide (TBHP) as the oxidant, demonstrating that benzylic and heterocyclic alcohols can be converted efficiently to the corresponding aldehydes. Excellent yields can be achieved (up to 99%) within a short reaction time and with great tolerance for functional groups.

New insights into the function and mechanisms of piRNA PMLCPIR in promoting PM-induced lung cancer.

Introduction: Extensive studies have established the correlation between long-term PM exposure and lung cancer, yet the mechanisms underlying this association remain poorly understood. PIWI-interacting RNAs (piRNAs), a novel category of small non-coding RNAs, serve important roles in various diseases. However, their biological function and mechanism in PM-induced lung cancer have not been thoroughly investigated.

piR-27222 mediates PM-induced lung cancer by resisting cell PANoptosis through the WTAP/mA axis.

PM pollution has been associated with the incidence of lung cancer, but the underlying mechanism is still unclear. PIWI-interacting RNAs (piRNAs), initially identified in germline cells, have emerged as a novel class of small non-coding RNAs (26 - 32 nucleotides) with diverse functions in various diseases, including cancer. However, the role and mechanism of piRNAs in the development of PM-induced lung cancer remain to be clarified.

Bi-Functional Electrolyte Additive Leading to a Highly Reversible and Stable Zinc Anode.

A stable stripping/plating process of the zinc anode is extremely critical for the practical application of aqueous zinc metal batteries. However, obstacles, including parasitic reactions and dendrite growth, notoriously deteriorate the stability and reversibility of zinc anode. Herein, Methyl l-α-aspartyl-l-phenylalaninate (Aspartame) is proposed as an effective additive in the ZnSO system to realize high stability and reversibility.

Functional polymorphisms in Benzo(a)Pyrene-induced toxicity pathways associated with the risk on laryngeal squamous cell carcinoma.

Benzo(a)Pyrene (BaP) is a well-known environmental carcinogen that poses a significant risk to human health. The pivotal genes and toxicity pathways have been identified as key events to construct the mode of action (MOA) of BaP. In this study, we focused on evaluating the association between genetic variants in BaP-disturbed toxicity pathways and the susceptibility of laryngeal squamous cell carcinoma (LSCC), based on the data of our previous genome-wide association analysis (GWAS).

Combined linkage analysis and association mapping identifies genomic regions associated with yield-related and drought-tolerance traits in wheat (Triticum aestivum L.).

Combined linkage analysis and association mapping identified genomic regions associated with yield and drought tolerance, providing information to assist breeding for high yield and drought tolerance in wheat. Wheat (Triticum aestivum L.) is one of the most widely grown food crops and provides adequate amounts of protein to support human health.

Threshold dynamics of a viral infection model with defectively infected cells.

In this paper, we investigate the global dynamics of a viral infection model with defectively infected cells. The explicit expression of the basic reproduction number of virus is obtained by using the next generation matrix approach, where each term has a clear biological interpretation. We show that the basic reproduction number serves as a threshold parameter.

Variations of disinfection byproduct precursors through conventional drinking water treatment processes and a real-time monitoring method.

In this investigation, raw water (RW), settled water (SW), and filtered water (FW) collected from a drinking water treatment plant were fractionated into 24 natural organic matter (NOM) fractions with varying molecular weights and hydrophobicity. The yields of disinfection byproducts (DBPs) obtained during the chlorination of the NOM fractions were explored. Results revealed that the 0-1 kDa, 5-10 kDa, and hydrophobic DBP precursors dominated RW.

Manipulation of Electrode Composition for Effective Water Management in Fuel Cells Fed with an Electrically Rechargeable Liquid Fuel.

The liquid fuel cell, with its high energy density and ease of fuel handling, has attracted great attention worldwide. However, its real application is still being greatly hindered by its limited power density. Hence, the recently proposed and demonstrated fuel cell, using an electrically rechargeable liquid fuel (e-fuel), is believed to be a candidate with great potential due to its significant performance advancement.

A Passive Fuel Cell Fed with an Electrically Rechargeable Liquid Fuel.

Passive fuel cells, using diffusion and natural convection for fuel delivery, are regarded as promising candidates for powering portable devices including mobile phones and laptops. However, the performance of passive fuel cells which employ typical liquid alcohol fuels are still limited, which thereby greatly hampered their commercialization progress. Recently, a novel concept named the electrically rechargeable liquid fuel (e-fuel), with its rechargeability, cost-effectiveness, and superior reactivity, has attracted increasing attention.

Application of Fourier transform ion cyclotron resonance mass spectrometry in deciphering molecular composition of soil organic matter: A review.

Swiftly deciphering soil organic matter (SOM) composition is critical for research on soil degradation and restoration. Recent advances in analytical techniques (e.g.

One-pot chemo-enzymatic conversion of D-xylose to furfuralcohol by sequential dehydration with oxalic acid plus tin-based solid acid and bioreduction with whole-cells.

In this study, organic acid could be used as co-catalyst for assisting solid acid SO/SnO-argil to convert hemicellulose-derived D-xylose into furfural. The relationship between pKa of organic acid and turnover frequency (TOF) of co-catalysis with organic acid plus SO/SnO-argil was explored on the conversion of D-xylose to furfural. Oxalic acid (pKa = 1.

Copper-Catalyzed Ring Expansion of Cyclopropyl Ketones/Formation of N-acyliminium/Hetero-[4 + 2]-Cycloaddition: A Route to Substituted Pentacyclic Isoindolin-1-one.

A Cu-catalyzed three-component cascade cyclization among 2-formylbenzonitrile, cyclopropyl ketones, and diaryliodonium salts for the construction of fused isoindolin-1-one compounds is achieved. Pentacyclic isoindolinone derivatives could be obtained in moderate to good yields. The proposed mechanism involved a ring expansion of cyclopropyl ketones/formation of N-acyliminium/hetero-[4 + 2]-cycloaddition process.

Structure of NADP-bound 7β-hydroxysteroid dehydrogenase reveals two cofactor-binding modes.

In mammals, bile acids/salts and their glycine and taurine conjugates are effectively recycled through enterohepatic circulation. 7β-Hydroxysteroid dehydrogenases (7β-HSDHs; EC 1.1.

Characterization of a novel cytochrome P450 from Amycolatopsis sp. CGMCC1149 for hydroxylation of lovastatin.

Wuxistatin, a novel and potent statin, is converted from lovastatin by Amycolatopsis sp. CGMCC1149. In the bioconversion, lovastatin is firstly hydroxylated to 3-hydroxymethyl lovastatin (product I) by a hydroxylase.

[Cloning and application of a novel hydroxylase in lovastatin conversion].

Wuxistatin, a novel and potent statin, is converted from lovastatin by Amycolatopsis sp. CGMCC1149. In the bioconversion, lovastatin is firstly hydroxylated by a hydroxylase.