Publications by authors named "Xiaoyu Huang"

Primary aldosteronism (PA) is one of the most common forms of secondary hypertension. Recent studies suggest that, compared with essential hypertension (EH), PA presents more severe disorders of glycolipid metabolism and organ damages. This case-control retrospective study aimed to ascertain clinical features and metabolic parameters between Chinese patients of PA and EH.

View Article and Find Full Text PDF

Background: This study aimed to develop and validate a computed tomography (CT)-based radiomics model to predict microsatellite instability (MSI) status in colorectal cancer patients and to identify the radiomics signature with the most robust and high performance from one of the three phases of triphasic enhanced CT.

Methods: In total, 502 colorectal cancer patients with preoperative contrast-enhanced CT images and available MSI status (441 in the training cohort and 61 in the external validation cohort) were enrolled from two centers in our retrospective study. Radiomics features of the entire primary tumor were extracted from arterial-, delayed-, and venous-phase CT images.

View Article and Find Full Text PDF

As an important global medical problem, hepatocellular carcinoma (HCC) has been recognized as the most frequent primary liver cancer and a leading cause of death among patients with cirrhosis. Surveillance of HCC using serum markers aims to reduce the disease-related mortality of HCC. MUC16 (mucin 16, also known as carbohydrate antigen 125, CA125) has been predicted as a tumor biomarker for many cancer types.

View Article and Find Full Text PDF

Objective: To explore the effect of a high-quality nursing model employing low-frequency pulse electrical stimulation combined with early systemic functional exercises on the function of the affected limb in brachial plexus injury patients.

Methods: A total of 98 brachial plexus injury patients admitted to our hospital were recruited as the research cohort. All the patients were treated with surgery to repair, release, and transfer or transplant nerves according to each patient's condition.

View Article and Find Full Text PDF

Peri-implantitis are a major problem causing implant failure these days. Accordingly, anti-infection during the early stage and subsequent promotion of osseointegration are two main key factors to solve this issue. Micro-arc oxidation (MAO) treatment is a way to form an oxidation film on the surface of metallic materials.

View Article and Find Full Text PDF

Background: Drug-coated balloons (DCBs) have emerged as potential alternatives to drug-eluting stents in specific lesion subsets for de novo coronary lesions. Quantitative flow ratio (QFR) is a method based on the three-dimensional quantitative coronary angiography and contrast flow velocity during coronary angiography (CAG), obviating the need for an invasive fractional flow reserve procedural. This study aimed to assess the serial angiographic changes of de novo lesions post-DCB therapy and further explore the cut-off values of lesion and vessel QFR, which predict vessel restenosis (diameter stenosis [DS] ≥50%) at mid-term follow-up.

View Article and Find Full Text PDF

A porous nanostructured covalent-organic framework (COF) has been prepared via condensation polymerization between the two building blocks of melem and hexaketocyclohexane octahydrate (represented as M-HO-COF). Basic characterizations revealed that the M-HO-COF network was composed of C=N and highly conjugated aromatic moieties, along with a high surface area, large pore size, remarkable electrochemical activity, and strong bioaffinity toward aptamer strands. Given that the vascular endothelial growth factor 165 (VEGF)-targeted aptamer was stably anchored over M-HO-COF via weak intermolecular forces, the prepared M-HO-COF network exhibited great potential as a sensitive and selective platform for the impedimetric VEGF aptasensor.

View Article and Find Full Text PDF
Article Synopsis
  • This study explored a new nonbridging external fixation technique for treating stage III ankle fractures, comparing it to traditional internal fixation methods.
  • Using cadaver models, researchers analyzed the effectiveness of both techniques in achieving anatomic reduction and stability of the fractures after surgery.
  • Results indicated that while the external fixation group experienced greater displacement of fracture fragments, both methods showed similar effectiveness in reduction rates, suggesting the nonbridging technique could be a viable alternative.
View Article and Find Full Text PDF

Clostridium perfringens beta2 (CPB2) toxin can cause intestinal damage and inflammatory responses in a variety of animals, which seriously endanger the healthy development of animal husbandry. Increasing evidence has demonstrated that microRNAs (miRNAs) can play an important regulatory role in the process of pathogenic infection. In our previous study, we found that miR-204 was highly expressed in the ileum tissues of the susceptible group diarrhea piglets after infection with Clostridium perfringens (C.

View Article and Find Full Text PDF

In this work, it is demonstrated for the first time that heterojunction nanowires, consisting of a gradient and segmented-like heterogeneous π-conjugated core with controllable length, composition and morphology, can be generated by co-self-seeding of oligo(p-phenylene vinylene) (OPV)- and oligo(p-phenylene ethynylene) (OPE)-containing block copolymers in spite of different chain lengths and molecular conformation for OPE and OPV. More importantly, based on the understanding of the formation of heterogeneous core by the co-self-seeding approach, a "heating/cooling" seeded growth route was developed, by which linear and branched heterojunction nanowires containing a segmented heterogeneous π-conjugated core of controlled length, composition and morphology can be obtained. This work provides a versatile platform to generate heterojunction nanowires with excellent controllability in length, composition, and morphology.

View Article and Find Full Text PDF

Background: Energy spectrum computed tomography (CT) has become a promising approach for the differential diagnosis of tumor subtypes.

Purpose: To explore the value of energy spectrum CT parameters in the differential diagnosis of high-grade clear cell renal cell carcinoma (ccRCC) and type II papillary renal cell carcinoma (pRCC).

Material And Methods: Forty-two cases of high-grade ccRCC and 28 cases of type II pRCC were retrospectively reviewed.

View Article and Find Full Text PDF

The sympathetic nervous system-catecholamine-uncoupling protein 1 (UCP1) axis plays an essential role in non-shivering adaptive thermogenesis. However, whether there exists a direct effector that physically connects catecholamine signalling to UCP1 in response to acute cold is unknown. Here we report that outer mitochondrial membrane-located AIDA is phosphorylated at S161 by the catecholamine-activated protein kinase A (PKA).

View Article and Find Full Text PDF

There is a lack of evidence about the relationship between microorganisms and non-carious cervical lesions (NCCLs) due to limited technologies. A group of 78 patients was enrolled for microbial 16S rRNA sequencing of dental plaques on normal and defective cervical surfaces. Parallel data from 39 patients were analysed with paired t tests, and Fusobacteriales exhibited significantly less distribution on NCCLs than on normal surfaces.

View Article and Find Full Text PDF

Method: The FSI model, based on MRI data of an atherosclerosis patient, was used to simulate the deformations of the plaque and lumen during the process of two kinds of typical cSMT (the high-speed, low-amplitude spinal manipulation and the cervical rotatory manipulation). The biomechanical parameters were recorded, such as the highest wall shear stress (WSS), the maximum plaque wall stress (PWS), the wall tensile stress (Von mises stress, VWTS), and the strain.

Result: The max_WSS was 33.

View Article and Find Full Text PDF

Purpose: To explore whether CT texture analysis can identify thin-cap fibroatheroma (TCFA) determined by optical coherence tomography (OCT).

Methods: Thirty-three patients with 43 lesions who underwent both CCTA and OCT within 3 months were retrospectively included. 12 conventional CT-derived plaque features, fat attenuation index (FAI) and 1691 plaque radiomics features were extracted to discriminate TCFA lesions and non-TCFA lesions determined by OCT.

View Article and Find Full Text PDF

Aims/introduction: Type 2 diabetes mellitus is correlated with systemic atherosclerosis. Statin therapies have been proved to reduce low-density lipoprotein cholesterol (LDL-C) level, protecting type 2 diabetes mellitus patients from cardiovascular events. Recently, more interest has been focused on the regression of lower extremity atherosclerotic disease (LEAD) for the potential prevention of amputation.

View Article and Find Full Text PDF

A novel heteronanostructure of nanodiamonds (NDs) and hydrogen-substituted graphdiyne (HsGDY) (denoted as HsGDY@NDs) was prepared for the impedimetric aptasensing of biomarkers such as myoglobin (Myo) and cardiac troponin I (cTnI). Basic characterizations revealed that the HsGDY@NDs were composed of nanospheres with sizes of 200-500 nm. In these nanospheres, NDs were embedded within the HsGDY network.

View Article and Find Full Text PDF

This vitro study aimed to evaluate the effects of 45S5 bioactive glass (BAG) and Er:YAG laser as desensitization treatments on the microtensile bond strength (MTBS) of fluorosed teeth. The 120 noncarious fluorosis were to obtain superficial dentin, being classified into four groups according to the Thylstrup and Fejerskov Index (TFI). Specimens from each group were randomly divided into five subgroups.

View Article and Find Full Text PDF
Article Synopsis
  • - Caffeine acts as a stimulant that many people, especially those working shifts, use to boost alertness, but its effects combined with sleep deprivation (SD) on cognitive performance are not well understood.
  • - Research found that sleep deprivation leads to cognitive issues and damage in the hippocampus, as well as increased neuron loss and apoptosis, which can be influenced by the levels of cAMP-PKA-CREB signaling.
  • - Low doses of caffeine can enhance cognitive function post-sleep deprivation, while high doses may worsen cognitive impairment, suggesting that the amount of caffeine consumed after sleep loss is crucial for brain health.
View Article and Find Full Text PDF

Giant panda () is an endangered mammalian species. Exploring immune and metabolic changes that occur in giant pandas with age is important for their protection. In this study, we systematically investigated the physiological and biochemical indicators in blood, as well as the transcriptome, and methylation profiles of young, adult, and old giant pandas.

View Article and Find Full Text PDF

A pH/GSH-responsive SO2 generation nanoplatform (BODS NPs) is established to achieve lysosomal escape and GSH depletion in tumor cells. O2˙- as the main ROS during SO2-mediated gas therapy can be accumulated through Cu/Zn-SOD enzymatic activity suppression and mitochondrial biogenesis, further exacerbating the oxidative stress and resulting in cell apoptosis.

View Article and Find Full Text PDF

Objective: microRNAs (miRNAs) can play a role in a variety of physiological and pathological processes, and their role is achieved by regulating the expression of target genes. Our previous high-throughput sequencing found that ssc-miR-185 plays an important regulatory role in piglet diarrhea, but its specific target genes and functions in intestinal porcine epithelial cell (IPEC-J2) are still unclear. We intended to verify the target relationship between porcine miR-185 and cell division cycle 42 (CDC42) gene in IPEC-J2 and to explore the effect of miR-185 on the proliferation of IPEC-J2 cells.

View Article and Find Full Text PDF

The transcription factor Blimp-1 is necessary for the B cell differentiation toward immunoglobulin-secreting plasma cells. However, the immunopathological mechanisms of Blimp-1 that regulates B cell differentiation remain unclear in MG. The purpose of this study was to perform a quantitative and functional analysis of Blimp-1 in MG.

View Article and Find Full Text PDF

Nitritation is currently known as a bottleneck for mainstream nitrite shunt or partial nitritation/anammox (PN/A). Here we propose a new approach to selectively eliminate nitrite oxidizing bacteria (NOB) for mainstream nitritation by low-dose ultraviolet-A (UVA) irradiation. The results showed that mainstream nitritation was rapidly achieved within 10 days with UVA irradiation at the dose of 0.

View Article and Find Full Text PDF