Publications by authors named "Xiaoyu Han"

Although burgeoning research has been conducted on the role of negative emotions (e.g., English learning burnout) in affecting students' academic achievement, there are limited studies on the intricate working mechanism between these two factors.

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Skeletal muscle dysfunction (SMD), one of the extrapulmonary complications in patients with chronic obstructive pulmonary disease (COPD), considerably influences patient prognosis. Mitochondria regulates their dynamic networks through a mitochondria quality control (MQC) mechanism, involving mitochondrial biogenesis, mitochondrial dynamics, and mitophagy. The MQC is crucial for mitochondrial homeostasis and health, and disruption of it can lead to mitochondrial damage, which is a key factor in the structural and functional impairment of skeletal muscle in COPD.

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High transductive loss at tissue injury sites impedes repair. The high dissipation characteristics in the electromechanical conversion of piezoelectric biomaterials pose a challenge. Therefore, supramolecular engineering and microfluidic technology is utilized to introduce slide-ring polyrotaxane and conductive polypyrrole to construct stress-electric coupling hydrogel microspheres.

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Background: Mobile learning is a valuable supplement to traditional education methods, but the current research on mobile learning is still insufficient. This study aimed to assess dental undergraduates' behaviors and attitudes towards mobile learning during course work and scientific research and to compare these findings to those of medical and non-medical students.

Methods: A cross-sectional survey was conducted among undergraduates at Sichuan University, China.

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Human bocavirus-1 (HBoV-1) has been associated with respiratory infections in both children and adults, often presenting symptoms similar to those of influenza. Understanding the prevalence and molecular characteristics of HBoV-1 in individuals with influenza-like illness (ILI) is essential for enhancing the diagnosis and treatment of respiratory infections in Kunming, Southwest China. Between December 2017 and December 2023, demographic and clinical data, along with respiratory tract specimens from individuals aged 0 to 97 years with ILI, were collected at three sentinel hospitals in Kunming.

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This study explored using small molecular weight hydrolysates from enzymolyzed thawed drip as cryoprotectants to preserve myofibrillar protein quality in pork patties during freeze-thaw cycles. Hydrolysates were added at 0.36 %, 0.

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Background: The study aimed to investigate the predictive value of delta-radiomics derived from computed tomography (CT) for pathological complete response (pCR) to neoadjuvant immunochemotherapy (NICT) among patients with esophageal squamous cell carcinoma (ESCC), helping clinicians determine whether to modify the neoadjuvant treatment strategy, proceed to surgery, or forgo surgery altogether.

Methods: A total of 140 ESCC patients from two institutions (Database 1 = 93; Database 2 = 47) who underwent NICT and surgery were retrospectively included in the study. The training set consisted of patients from Database 1, while the testing set included patients from Database 2.

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Article Synopsis
  • The paper introduces a new integrated metasurface antenna that combines a radiating patch with a quadru-arc structure to enhance radiation and scattering capabilities.
  • It leverages phase manipulation in the power division feed network and adjustments to the quadru-arc structure for efficient control over radiation and X-polarization scattering functions.
  • Two distinct antenna configurations were tested, achieving impressive gains (16 dBi and 22.3 dBi) and effective vortex beam scattering by optimizing the scattering function through advanced algorithms, followed by successful physical fabrication and measurement of the design.
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A degradation modeling method of marine gas turbines for the overhaul cycle is proposed to address the problem of insufficient data sets for fault diagnosis and trend prediction algorithm validation. First, a nonlinear model of the marine three-shaft gas turbine gas path was established. The degradation path and component degradation models were subsequently obtained.

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An efficient and highly enantioselective synthesis of tipranavir is realized based on an iridium-catalyzed asymmetric allylic substitution. High yield and diastereoselectivity (>20:1), as well as excellent enantioselectivity (99% ), were obtained for the key intermediate through direct asymmetric alkylation reaction of dihydropyranone with allylic -butyl carbonate. Anti-AIDS drug of tipranavir was finally accomplished in 8 steps and 6 pots starting from commercially available 1-phenyl-3-hexanone in 20.

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Despite extensive global attention on microplastic pollution, our understanding of the pathways underlying microplastic translocation, accumulation, and their potential impacts on ecosystems and human health through the food chain remains incomplete. To investigate the translocation and accumulation of microplastics from insects to mammals, we developed a novel oral exposure model that Tenebrio molitor larvae (yellow mealworms, invertebrate terrestrial insects) were firstly orally exposed to both micro and nanometer-sized plastics (M/NPs), and subsequently fed as a food source to mice (mammals). Our results provide clear evidence that micro/nanoplastics (M/NPs) do indeed translocate through the food chain, from lower to higher trophic levels.

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The rapid start-up and granulation of a single-stage partial nitritation anammox granular sludge (PN/AnGS) system under limited seed sludge conditions is crucial for its practical application. This study proposed an aerobic granular sludge (AGS) - based strategy, enhanced the enrichment of anammox bacteria (AnAOB), and shortened the start-up time of PN/AnGS system by 20.5%.

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Background: Different pathological stages of lung adenocarcinoma require different surgical strategies and have varying prognoses. Predicting their invasiveness is clinically important. This study aims to develop a nomogram to predict the invasiveness of lung adenocarcinoma manifesting as ground-glass nodules (GGNs) based on follow-up computed tomography (CT) imaging.

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Objectives: To mitigate the incidence of misdiagnosis and distinguish between gastric fundic tumors (GFTs) and thickened diaphragmatic crura (TDC).

Materials And Methods: Computed tomographic enterography (CTE) data from 3844 cases and computed tomographic gastrography (CTG) data from 4351 cases were retrospectively analyzed. A total of 105 cases were selected and categorized into three groups: 47 cases with TDC examined via CTE, 31 with adenocarcinoma, and 27 with gastrointestinal stromal tumors (GIST) examined via CTG.

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Background: The effect of different surgical methods on postoperative lung function in patients with lung cancer is still inconclusive. The main objective of this study was to compare the effects of video-assisted thoracic surgery (VATS) lobectomy and segmentectomy on postoperative pulmonary function and compensatory changes in patients undergoing lung cancer surgery.

Methods: A total of 120 patients (82 VATS lobectomy, 38 VATS segmentectomy) were assessed for demographic characteristics, baseline pulmonary function, tumor volume, T stage, and histological grade.

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Article Synopsis
  • The study aimed to evaluate how well a deep learning model using multiparametric MRI can predict tumor deposits in rectal cancer patients and their prognostic implications.
  • A total of 529 rectal cancer patients from two surgical centers were analyzed, with data divided into training, internal validation, and external validation sets.
  • The results indicated a strong predictive capability of the combined clinical and deep learning models, with the nomogram performing best in predicting outcomes, as shown by the AUC values and survival analysis.
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The production of top-quality wines is closely related to the quality of the wine grapes. In wine grapes (Vitis vinifera L., Vv), sugar is a crucial determinant of berry quality, regulated by an interplay of various transcription factors and key kinases.

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  • This study looked at how well a computer program can tell the difference between two types of tumors: solitary fibrous tumor (SFT) and angiomatous meningioma (AM).
  • Researchers used MRI scans from 171 patients and analyzed a lot of detailed features from those scans.
  • They found that the program they developed was really good at making this distinction, achieving a very high success rate with its predictions.
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  • Scientists studied how a special type of MRI, called time-dependent diffusion MRI, can tell us about changes in the liver as it gets worse from fibrosis (a buildup of scar tissue) to cirrhosis (severe liver damage).
  • They ran tests on 60 rats with liver fibrosis and compared their results to five rats that were healthy, using advanced imaging techniques.
  • The MRI helped measure things like cell size and how much space the cells take up, showing that as liver fibrosis got worse, cells got smaller and more crowded, and these results matched well with direct measurements taken under a microscope.
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  • The study aimed to create and validate deep-learning models to predict microsatellite instability (MSI) in rectal cancer patients using clinical data, multiparametric MRI, and pathology slides.* -
  • Researchers analyzed data from 467 patients, splitting them into training, internal validation, and external validation sets, while utilizing specific MRI sequences and staining techniques for comprehensive analysis.* -
  • The final models combined clinical predictors with deep-learning scores from MRI and pathology images, achieving varying predictive performance metrics, with the clinical model's AUC values indicating effectiveness at predicting MSI.*
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The partial denitrification/anammox (PD/A) process is receiving increasing attention due to its cost-effectiveness advantages. However, effective strategies to alleviate organic matter inhibition and promote anammox activity have been proven to be a big challenge. This study investigated the effects of three types of iron (nano zero-valent iron (nZVI), Fe(II), and Fe(III)) on the PD/A process.

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  • The emergence of Rickettsia barbariae, a tick-borne disease, has raised global concern since it was first detected in humans in Italy in 2008 and later in northwestern China.
  • Researchers isolated the bacteria for the first time from tick eggs in China and sequenced its whole genome, giving it a modified name according to international standards.
  • The genome analysis showed that this strain is closely related to other harmful rickettsiae, revealing its potential to be pathogenic and underscoring the need for better monitoring of tick-borne diseases in humans.
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Background: Digital subtraction angiography (DSA) devices are commonly used in numerous interventional procedures across various parts of the body, necessitating multiple scans per procedure, which results in significant radiation exposure for both doctors and patients. Inspired by generative artificial intelligence techniques, this study proposes GenDSA, a large-scale pretrained multi-frame generative model-based real-time and low-dose DSA imaging system.

Methods: GenDSA was developed to generate 1-, 2-, and 3-frame sequences following each real frame.

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Background: Varicella pneumonia is one of the most common and severe complications of chickenpox infection. This study aimed to describe the clinical and radiological features of varicella pneumonia in a cluster of immunocompetent adolescents.

Methods: A retrospective analysis was conducted on a cohort of adolescent patients diagnosed with varicella pneumonia at Wuhan Jinyintan Hospital between February 2023 and May 2023.

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