Publications by authors named "Xiaoying Zong"
Hemophilic arthropathy (HA) is a condition caused by recurrent intra-articular bleeding in patients with hemophilia. Pro-inflammatory cytokines play a crucial role in the pathogenesis of HA. Our previous research demonstrated that a novel compound, piperazino-enaminone (JODI), effectively inhibited pro-inflammatory cytokines, including IL-6, MCP-1, MIP-1α, and MIP-1β, in a mouse model of hemarthrosis.
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- * A study involving 3,025 hemodialysis patients found that those sleeping more than 7 hours were more likely to face hypertension and high levels of sugar and fats in the blood, while shorter sleep durations also increased risks for some conditions.
- * The research revealed that poor sleep quality had a negative impact on good cholesterol (HDL) and was linked to high triglycerides, with notable differences seen between genders.
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- The study investigates the relationship between aging, dialysis duration, and the control of calcium, phosphorus, and iPTH levels in hemodialysis patients, highlighting that aging is a significant issue in this group.
- Conducted on 3,025 hemodialysis patients in China, the research found that those with poor control of calcium and phosphorus levels, especially those undergoing dialysis for longer periods, showed a disparity between chronological age and biological age.
- The results suggest that improper metabolic control can accelerate aging in hemodialysis patients, indicating the need for further research on the importance of regulating these minerals to potentially slow down the aging process.
Adeno-associated virus (AAV) vectors have been successfully used to deliver genes for treating rare diseases. However, the systemic administration of high AAV vector doses triggers several adverse effects, including immune response, the asymptomatic elevation of liver transaminase levels, and complement activation. Thus, improving AAV transduction and reducing AAV dosage for treatment is necessary.
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- Serum magnesium (Mg) levels are linked to various health issues like insulin resistance and inflammation, and this study aims to explore how Mg relates to allostatic load (AL) in hemodialysis patients.
- Conducted in Anhui Province, China, the research involved 3,025 hemodialysis patients, ultimately including 1,222 in the analysis, revealing that 23.4% had high AL levels.
- Findings indicate that lower serum Mg is associated with higher odds of high AL, suggesting that maintaining higher Mg levels could lower health risks for these patients, warranting further research.
Background: Chronic kidney disease-mineral bone disorder (CKD-MBD) is a common comorbidity in patients with CKD. The study aims to describe the control rates of serum-corrected calcium (Ca), phosphate (P) and intact parathyroid hormone (iPTH) and its risk factors among maintenance hemodialysis (MHD) patients in Anhui Province of China.
Methods: The study was conducted in 27 hemodialysis centers of Anhui Province between January 1st 2020 and December 31th 2020.
Subclinical bleeding is a haemorrhage event not clinically detected in haemophilia, and no reliable method is available for predicting subclinical bleeding. We investigated whether haemophilia mice have subclinical haemorrhage and evaluated potential biomarkers including multiple cytokine changes to predict subclinical haemorrhage. Plasma from naïve FVIII-/- and FIX-/- mice and their wild-type counterparts (FVIII WT and FIX WT, respectively) were measured for prothrombin fragment 1 + 2 (F1 + 2) and multiple cytokines.
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