Association between magnesium depletion score and Klotho levels among U.S. adults: Findings from NHANES 2007-2016.

Background: Magnesium is a vital mineral that plays a crucial role in various physiological processes, and its imbalance has been associated with many chronic aging-related diseases. Traditional assessment methods are insufficient, and the Magnesium Depletion Score (MDS) has been proposed as a significant indicator. Klotho, a transmembrane protein, is involved in aging regulation and oxidative stress modulation.

Mirror substrates specificity of a 2, 3-dihydroxypropanesulfonate degrading enzyme in sulfate-reducing bacteria.

Ubiquitous R- and S-enantiomers of 2,3-dihydroxypropanesulfonate (DHPS), organic sulfur compounds produced by photosynthetic organisms, serve as common nutrient and energy sources for specific bacteria. While most known DHPS-degrading enzymes exhibit enantioselectivity, this study introduces a unique dehydrogenase, DhpA from the sulfate-reducing bacterium Desulfovibrio sp. DF1, capable of efficiently metabolizing both R- and S-DHPS to 3-sulfolactaldehyde (SLA).

Association of handgrip strength weakness and asymmetry with low physical performance among Chinese older people.

Background: Handgrip strength (HGS) weakness and asymmetry are both abnormal conditions of upper-limb muscle strength. The association between HGS weakness and physical performance is controversial, and the link between HGS asymmetry and physical performance remains unclear.

Aims: This study aimed to investigate the associations of HGS weakness and asymmetry separately and concurrently with low physical performance among Chinese older people.

Microneedle-Delivered PDA@Exo for Multifaceted Osteoarthritis Treatment via PI3K-Akt-mTOR Pathway.

Osteoarthritis (OA) is marked by cartilage deterioration, subchondral bone changes, and an inflammatory microenvironment. The study introduces the Microneedle-Delivered Polydopamine-Exosome (PDA@Exo MN), a therapeutic that not only preserves cartilage and promotes bone regeneration but also improves localized drug delivery through enhanced penetration capabilities. PDA@Exo MN shows strong reactive oxygen species (ROS) scavenging abilities and high biocompatibility, fostering osteogenesis and balancing anabolic and catabolic processes in cartilage.

M2 macrophage-polarized anti-inflammatory microneedle patch for accelerating biofilm-infected diabetic wound healing via modulating the insulin pathway.

Macrophages play a pivotal role in the healing of diabetic ulcers. The sustained elevation of glucose levels damages the insulin signaling pathway in macrophages, leading to dysfunctional macrophages that struggle to transition from pro-inflammatory (M1) to reparative (M2) states. Therefore, modulating macrophage inflammatory responses via the insulin pathway holds promise for diabetic ulcer treatment.

Effects of climate change and deep fertilization on the growth and yield of winter wheat in the Loess Plateau of China.

Background: Global temperature is projected to rise continuously under climate change, negatively impacting the growth and yield of winter wheat. Optimizing traditional agricultural measures is necessary to mitigate potential winter wheat yield losses caused by future climate change. This study aims to explore the variations in winter wheat growth and yield on the Loess Plateau of China under future climate change, identify the key meteorological factors affecting winter wheat growth and yield, and analyze the differences in winter wheat yield and root characteristics under different fertilization depths.

Long-term outcomes of IVUS-guided and angiography-guided drug-eluting stent implantation for left main coronary artery disease: a retrospective consort study.

Background: In patients with unprotected left main coronary artery disease (ULMCAD), this study compared the long-term prognosis of drug-eluting stent insertion guided by intravascular ultrasonography (IVUS) vs. angiography.

Patients And Methods: This retrospective consort investigation was performed in December 2021.

Higher dietary live microbe intake is associated with a lower risk of sarcopenia.

Objective: This study aimed to investigate the potential association between dietary live microbe intake and sarcopenia.

Methods: Data from 5368 participants were gathered from the National Health and Nutrition Examination Survey (NHANES). Dietary information was assessed using a self-report questionnaire.

GDF11 improves hippocampal neurogenesis and cognitive abilities in diabetic mice by reducing neural inflammation.

Background: The cognitive decline associated with type 2 diabetes (T2D) is often attributed to compromised hippocampal neurogenesis and exacerbated neural inflammation. This study investigates the therapeutic potential of growth differentiation factor 11 (GDF11) in reversing these neurodegenerative processes in diabetic mice.

Result: We utilized a murine model of T2D and examined the effects of GDF11 on learning, memory, neurogenesis, and neuroinflammatory markers.

Enantioselective transformation of phytoplankton-derived dihydroxypropanesulfonate by marine bacteria.

Chirality, a fundamental property of matter, is often overlooked in the studies of marine organic matter cycles. Dihydroxypropanesulfonate (DHPS), a globally abundant organosulfur compound, serves as an ecologically important currency for nutrient and energy transfer from phytoplankton to bacteria in the ocean. However, the chirality of DHPS in nature and its transformation remain unclear.

Development and advancements in rodent MRI-based brain atlases.

Rodents, particularly mice and rats, are extensively utilized in fundamental neuroscience research. Brain atlases have played a pivotal role in this field, evolving from traditional printed histology atlases to digital atlases incorporating diverse imaging datasets. Magnetic resonance imaging (MRI)-based brain atlases, also known as brain maps, have been employed in specific studies.

Factor analysis of hydrologic services in water-controlled grassland ecosystems by InVEST model and geodetector.

Water conservation is highly important for a successful desert grassland ecosystem, but there was no comprehensive view on how to assess influencing factors in managing and addressing water yield and water conservation in desert steppe. The Integrated Valuation of Ecosystem Services and Trade-offs (InVEST) model, which is specifically used for the assessment of ecosystem services, was combined with geographic detectors to identify the priority areas for water conservation function and analyze the driving factors of water conservation in the Tabu River Basin, Inner Mongolia Autonomous Region, China, using different meteorological data sources. (i) The InVEST model has the advantage of modeling water yield and water conservation at spatial scales by fusion downscaling data.

Interactions between Helicobacter pylori infection and host metabolic homeostasis: A comprehensive review.

The microbiota actively and extensively participates in the regulation of human metabolism, playing a crucial role in the development of metabolic diseases. Helicobacter pylori (H. pylori), when colonizing gastric epithelial cells, not only induces local tissue inflammation or malignant transformation but also leads to systemic and partial changes in host metabolism.

Impacts of climate change on winter wheat net primary production: the regulatory role of crop management.

Background: The Huang-Huai-Hai Plain (3HP) is the main agricultural area in China. Although climate change (CC) and crop management (CM) are considered factors affecting the winter wheat net primary production (NPP) in this region, their effects remain unclear. In the present study, we evaluated the relative contributions of CC and CM to winter wheat aboveground NPP (ANPP) in the 3HP and the relationships between climatic factors and ANPP using the first-order difference method from 2000 to 2020.

Antioxidant-Engineered Milk-Derived Extracellular Vesicles for Accelerating Wound Healing via Regulation of the PI3K-AKT Signaling Pathway.

Inspired by the experience of relieving inflammation in infants with milk, antioxidant-engineered milk-derived extracellular vesicles (MEVs) are developed to evaluate their potential for accelerating wound healing. In this work, MEVs with polydopamines (PDA) are engineered using the co-extrusion method. Subsequently, the authors incorporated them into a Schiff-based crosslink hydrogel, forming a skin dosage form that could facilitate the wound healing process.

Effects of urea solution concentration on soil hydraulic properties and water infiltration capacity.

Elucidating the effect of fertigation on soil hydraulic parameters and water-solute transportation is fundamental to the design of farmland irrigation systems and their sustainable utilization. Few studies have focused on soil hydraulic parameters or water infiltration characteristics or how they are influenced by urea solution concentration. In this study, the clay loam and sandy loam in Yangling District of Shaanxi Province, China, were used as test soil, and experiments involving seven urea solution concentrations (0.

Effects of NSC in different organs and at different growth stages on the yield of oil peony Fengdan with different ages.

Non-structural carbohydrates (NSC) as resource reserves of plants play important roles in energy supply for normal growth and reproduction under environmental stress. The yield of perennial crops is mainly determined by the carbohydrate production and allocation in the current growth season, as well as the re-allocation of NSC reserves. However, the contribution of NSC to crop yield has not been fully determined.

Multi-objective synchronous calibration and Pareto optimality of runoff and sediment parameters in an arid and semi-arid watershed.

Calibration methodologies must extract as much information as possible from available data, but it is not well understood in investigating the multi-objective synchronous calibration strategy by using multiple sources of information and by exploiting the data in better ways. The non-dominated sorting genetic algorithm II (NSGA-II) is introduced to study the calibration performance of runoff and sediment parameters under nine targeted scenarios, which considers the best choice to obtain high-cost performance results for decision makers through multi-objective optimization and the calculation of Pareto-optimal front with a high precision. (i) SWAT model has good adaptability in the runoff simulation of the Yanhe River watershed.

MnO@Au nanostructures supported colorimetric biosensing with duplex-specific nuclease-assisted DNA structural transition.

Manganese dioxide (MnO) nanosheets are regarded as a new class of two-dimensional nanomaterials with several attractive properties with enormous progress in biomedical fields. Gold nanoparticles (AuNPs) are also important biocompatible nanomaterials with unusual optical properties. Hetero-nanostructure of MnO and AuNPs with the medium of DNA is an interesting topic.

Gamma-Aminobutyric Acid Promotes Beige Adipocyte Reconstruction by Modulating the Gut Microbiota in Obese Mice.

Given the increasing prevalence of obesity, the white-to-beige adipocyte conversion has attracted interest as a target for obesity treatment. Gamma-aminobutyric acid (GABA) treatment can reduce obesity, but the underlying mechanism remains unclear. Here, we aimed to investigate the mechanism by which GABA triggers weight loss by improving the beiging of inguinal white adipose tissue (iWAT) and the role of gut microbiota in this process.

Increasing areas of aquaculture ponds and reservoirs reshape runoff coefficients: evidence from a subtropical catchment, China.

Detention pond is a key storm water management measure employed both to attenuate surface runoff and to regulate depression storage, yet the effects of aquaculture ponds and reservoirs on runoff coefficient are not well quantified in a subtropical humid monsoon climate zone, China. Here, a set of six subcatchments ranging in size from 0.7 hm to 10,000 hm were evaluated over the 2011-2015 period.