Publications by authors named "Xiaoyi Lei"
Augmenting antitumor efficacy of Th17-derived Th1 cells through IFN-γ-induced type I interferon response network via IRF7.
Proc Natl Acad Sci U S A
November 2024
The importance of CD4 T cells in cancer immunotherapy has gained increasing recognition. Particularly, a specific subset of CD4 T cells coexpressing the T helper type 1 (Th1) and Th17 markers has demonstrated remarkable antitumor potential. However, the underlying mechanisms governing the differentiation of these cells and their subsequent antitumor responses remain incompletely understood.
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- * She underwent a combination of chemotherapy and immunotherapy, specifically the XELOX regimen with tislelizumab, leading to the complete disappearance of liver metastases and significant shrinkage of the primary tumor.
- * Following a successful laparoscopy and radical total gastrectomy, which showed no remaining cancer, the patient now receives ongoing treatment to address any potential residual disease, showcasing the effectiveness of combining immunotherapy with traditional chemotherapy in advanced cancer cases.
A Convexity-Preserving Level-Set Method for the Segmentation of Tumor Organoids.
Bioengineering (Basel)
June 2024
Tumor organoid cultures play a crucial role in clinical practice, particularly in guiding medication by accurately determining the morphology and size of the organoids. However, segmenting individual tumor organoids is challenging due to their inhomogeneous internal intensity and overlapping structures. This paper proposes a convexity-preserving level-set segmentation 4 model based on the characteristics of tumor organoid images to segment individual tumor organoids precisely.
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- - Oxyntic gland neoplasm (OGN) is a rare type of gastric cancer, with a prevalence of 0.047% among the patients analyzed in a study involving 36 individuals from 2019 to 2023, most of whom were around 55 years old.
- - Most OGNs were small (≤10 mm), primarily found in the upper stomach, and showed distinctive features like slight elevation and dilated blood vessels.
- - Both endoscopic treatments (EMR-P and ESD) were effective and safe, with no complications reported, and EMR-P was found to be at least as effective as ESD, especially for smaller tumors, leading to favorable overall prognosis.
Background: Underwater endoscopic mucosal resection (UEMR) is increasingly applied in the treatment of superficial non-ampullary duodenal epithelial tumors (SNADETs). This meta-analysis aimed to assess the efficacy and safety of UEMR for SNADETs ≤20 mm in comparison with conventional endoscopic mucosal resection (CEMR).
Methods: The following electronic databases were searched from 2012 until November 20, 2021: PubMed, Embase, Scopus, Web of Science databases, and Cochrane Library.
Background: This study aimed to evaluate the efficacy and safety of high-dose dual therapy for Helicobacter pylori (H. pylori) eradication compared to bismuth-containing quadruple therapy.
Methods: The electronic database of PubMed, Embase, and Cochrane Library were searched from inception to March 18, 2021.
Background: Gastric cancer (GC) or gastroesophageal junction (GEJ) cancer with HER2 overexpression is highly invasive, with a poor prognosis. With the development of new targeted agents, which agents have ideal therapeutic effects must be determined. This network meta-analysis analyzed the effectiveness and tolerability of targeted agents combined with chemotherapy in HER2-positive GC/GEJ cancer.
View Article and Find Full Text PDFStudy of p-SiC/n-GaN Hetero-Structural Double-Drift Region IMPATT Diode.
Micromachines (Basel)
July 2021
Nowadays, the immature p-GaN processes cannot meet the manufacturing requirements of GaN impact ionization avalanche transit time (IMPATT) diodes. Against this backdrop, the performance of wide-bandgap p-SiC/n-GaN heterojunction double-drift region (DDR) IMPATT diode is investigated in this paper for the first time. The direct-current (DC) steady-state, small-signal and large-signal characteristics are numerically simulated.
View Article and Find Full Text PDFBackground And Objective: Although various endoscopic resection techniques have been established for rectal carcinoid tumors, there remains controversy regarding the best endoscopic treatment modality for these tumors. This study aimed to evaluate and compare the therapeutic efficacy and safety of EMR with circumferential incision (EMR-CI) and endoscopic submucosal dissection (ESD) for endoscopic resection of rectal carcinoid tumors.
Methods: From March 2012 to June 2016, 66 rectal carcinoid tumors in 66 patients were resected by using EMR-CI (n=30) or ESD (n=36).
Background: Noncirrhotic hepatocellular carcinoma (HCC) is rare. The aim of this study was to evaluate the published evidence for hepatectomy in patients with noncirrhotic HCC.
Methods: A literature search was conducted in PubMed database for eligible studies from the time of inception to March 2014.