Publications by authors named "Xiaoyi Lai"

Amplification of MYCN is a major oncogenic driver of high-risk neuroblastomas. We previously developed CCC-002, a MYCN-selective pyrrole-imidazole polyamide conjugated to a DNA alkylating agent. Administration of CCC-002 to MYCN-amplified (MYCN-amp) neuroblastoma cells triggered the activation of DNA damage responses.

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Alpha-synuclein (α-syn) is a major pathological marker of Parkinson's disease (PD), and its abnormal expression and aggregation lead to dopaminergic neuron degeneration, in which oxidative stress plays an important role. However, the exact molecular mechanism by which α-syn causes PD remains unclear. In this study, exogenous α-syn, also known as α-syn preformed fibrils (α-syn PFFs), was used to construct in vivo and in vitro models of PD.

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Article Synopsis
  • A new type of circularly polarized thermally activated delayed fluorescence (CP-TADF) materials, named (R)-ad-PXZ and (S)-ad-PXZ, were developed.
  • These materials emit orange-red light at a wavelength of 602 nm and demonstrate noticeable chiroptical properties in both liquid and solid forms.
  • A device made from these materials achieved a maximum external quantum efficiency of 9.0% and a value of 10 in performance measurements.
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Article Synopsis
  • MYCN amplification (MYCN-amp) is a crucial factor in predicting high-risk neuroblastoma and affects how these cells respond to certain treatments.
  • Research shows that combining CCC-002, a DNA-damaging agent aimed at MYCN, with PARP inhibitors makes MYCN-amp neuroblastoma cells more sensitive to treatment, enhancing DNA damage signals.
  • The combination therapy not only boosts the effectiveness of CCC-002 in reducing MYCN levels but also significantly increases cell death, suggesting a promising new approach for treating this aggressive cancer.
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To address the requirements of sonar imaging, such as high receiving sensitivity, a wide bandwidth, and a wide receiving angle, an AlN PMUT with an optimized ratio of 0.6 for the piezoelectric layer diameter to backside cavity diameter is proposed in this paper. A sample AlN PMUT is designed and fabricated with the SOI substrate-based bulk MEMS process.

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Solid-state qubits with a photonic interface is very promising for quantum networks. Color centers in silicon carbide have shown excellent optical and spin coherence, even when integrated with membranes and nanostructures. Additionally, nuclear spins coupled with electron spins can serve as long-lived quantum memories.

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A solid-state approach for quantum networks is advantageous, as it allows the integration of nanophotonics to enhance the photon emission and the utilization of weakly coupled nuclear spins for long-lived storage. Silicon carbide, specifically point defects within it, shows great promise in this regard due to the easy of availability and well-established nanofabrication techniques. Despite of remarkable progresses made, achieving spin-photon entanglement remains a crucial aspect to be realized.

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Parkinson's disease (PD) is characterized by the progressive death of dopamine (DA) neurons and the pathological accumulation of α-synuclein (α-syn) fibrils. In our previous study, simulated PHB2 phosphorylation was utilized to clarify the regulatory role of c-Abl in PHB2-mediated mitophagy in PD models. In this investigation, we employed an independently patented PHB2Y121 phosphorylated antibody in the PD model to further verify that the c-Abl inhibitor STI571 can impede PHB2Y121 phosphorylation, decrease the formation of α-Syn polymers, and improve autophagic levels.

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Exciplex systems are promising candidates for thermally activated delayed fluorescence (TADF) molecules because of the small energy difference between the lowest singlet and triplet excited states (ΔE). However, realizing high-efficiency and low-external-quantum-efficiency (EQE) roll-off in solution-processed organic light-emitting diodes (OLEDs) using an exciplex system remains a formidable challenge. In this study, two (HLCT)-type isomers with a spiro skeleton, 2-BuspoCz-TRZ and 10-BuspoCz-TRZ, are designed and synthesized as acceptors of exciplexes, where tert-butylspirofluorene indole is regarded as a donor and the triazine unit as an acceptor.

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Chiral liquid-crystalline emitters based on 9,9-dimethyl-10-(4-(phenylsulfonyl)phenyl)-9,10-dihydroacridine and a functionalised binaphthol show smectic liquid crystal phases and circularly polarised blue fluorescence with a high luminescence dissymmetry factor || of 0.13. Solution-processable organic light-emitting diodes (OLEDs) based on the enantiomers were explored.

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Article Synopsis
  • Endoplasmic reticulum stress and mitochondrial dysfunction are crucial in Parkinson's disease, but how they interact is still not well understood.
  • This study investigates the role of Prohibitin-2 (PHB2), an autophagy receptor in mitochondria, and its relationship with the protein Parkin and the endoplasmic reticulum stress regulator PERK in the context of Parkinson's disease.
  • Using mouse and cell models of Parkinson's disease, the research found that loss of PHB2 worsens neuron damage and motor functions, while overexpression of PHB2 and Parkin promotes mitophagy, indicating that PHB2 may influence disease progression through its interactions with PERK and Parkin.
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Two-dimensional heterostructures have recently gained broad interest due to potential applications in optoelectronic devices. Their reduced dimensionality leads to novel physical effects beyond conventional bulk electronics. However, the optical properties of the 2D lateral heterojunctions have not been completely characterized due to the limited spatial resolution, requiring nano-optical techniques beyond the diffraction limit.

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Oxidative stress plays a crucial role in the occurrence and development of Parkinson's disease (PD). Rutin, a natural botanical ingredient, has been shown to have antioxidant properties. Therefore, the aim of this study was to investigate the neuroprotective effects of rutin on PD and the underlying mechanisms.

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Oxidative stress plays a key role in cerebral ischemia/reperfusion injury. Artemisinin (ART) has antioxidative stress activity in addition to its powerful antimalarial effects. In this article, we investigated the effect of ART on OGD/R-induced oxidative stress injury and its underlying mechanisms.

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Mitophagy and oxidative stress play important roles in Parkinson's disease (PD). Dysregulated mitophagy exacerbates mitochondrial oxidative damage; however, the regulatory mechanism of mitophagy is unclear. Here, we provide a potential mechanistic link between c-Abl, a nonreceptor tyrosine kinase, and mitophagy in PD progression.

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Background: Activating mutations of the KRAS occurs in >90% of pancreatic ductal adenocarcinoma (PDAC) cases. However, direct pharmacological targeting of the activated KRAS protein has been challenging. We previously reported that KR12, a DNA-alkylating pyrrole-imidazole polyamide designed to recognize the KRAS G12D/V mutation, showed an anti-tumor effect in colorectal cancer.

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The progression of Parkinson's disease (PD) is often accompanied by the loss of substantia nigra dopaminergic neurons, mitophagy damage, learning, and memory impairment. Idebenone is a therapeutic drug that targets the mitochondria of neurodegenerative diseases, but its role in Parkinson's disease and its pathological mechanism are still unclear. The purpose of this study was to investigate whether idebenone could improve behavioral disorders, especially motor, learning, and memory disorders, in mouse PD models and to explore its molecular mechanism.

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Background: Parkinson's disease (PD) is the second most common neurodegenerative disease after Alzheimer's disease. The oxidative stress is an important component of the pathogenesis of PD. Artemisinin (ART) has antioxidant and neuroprotective effects.

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Parkinson's disease (PD) is a neurodegenerative disease caused by the loss of dopaminergic neurons. It is characterized by static tremors, stiffness, slow movements, and gait disturbances, but it is also accompanied by anxiety and depression. Our previous study showed that atorvastatin could reduce the risk of PD, but the mechanism is still unclear.

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In insects, inward-rectifying potassium (Kir) channels regulate vital physiological functions, such as feeding behavior, silk secretion, renal excretion, and immune function. Therefore, they offer promising potential as targets for insecticides. Three types of Kir subunits have been identified in Diptera and Hemiptera, but the Kir subunits of Lepidoptera still remain unclear.

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The large-conductance calcium-activated potassium channel (BK ) plays an important role in the regulation of insect neural circuits and locomotion, and thus is a potential target of insecticides. In this study, iberiotoxin, an inhibitor of BK , was found to prolong the anesthetic time of ethyl acetate on Plutella xylostella larvae. Therefore, the coding sequence of slowpoke gene coding the alpha subunit of BK was cloned to investigate the function of this channel in P.

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Neuroinflammation and oxidative stress play key roles in the pathological development of Parkinson's disease (PD). Nerve growth factor-induced gene B (Nur77) is closely related to dopamine neurotransmission, and its pathogenesis is unclear. This study aims to investigate the role and mechanism of Nur77 in a cell model of Parkinson's disease.

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The cognitive function impairment may be related to the inflammation of the hippocampus in Parkinson's disease. Simvastatin can play a positive role in Parkinson's disease. The purpose of this study was to investigate whether simvastatin could improve behavioral disorders, especially depression, anxiety and cognitive function in mouse PD models, and further explore the molecular mechanism.

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Tyramine receptors (TARs) can be activated by tyramine (TA) or octopamine (OA) and have been shown to be related to physiological regulation (e.g., gustatory responsiveness, social organization, and learning behavior) in a range of insect species.

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Background: Statins have key lipid-lowering, anti-inflammatory, and anti-oxidative effects. However, it remains unclear whether statins are beneficial to patients with Parkinson's disease (PD). This study aimed to evaluate the relationship between statins and PD through a systematic review.

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