Plaque erosion risk and JAK2 V617F variant.

Background And Aims: Clonal haematopoiesis of indeterminate potential (CHIP) can increase the risk of myocardial infarction (MI). Among various CHIP mutations, JAK2 V617F substantially elevated this risk. However, the specific associations between JAK2 V617F and two mechanisms of MI, plaque erosion and plaque rupture, remain unclear.

Demonstration of standing cavity Brillouin random fiber lasers using double fiber Bragg grating arrays.

Bidirectional feedback by fiber Bragg grating arrays (FBGAs) reduced the loss of the cavity and increased stimulated Brillouin scattering (SBS) gain by bi-directional Stokes wave through FBGA associated Rayleigh feedback of the pump wave. As a result, the Q value of the Brillouin random fiber laser (BRFL) increased significantly, which leads to narrow linewidth. This is different from the ring configuration with unidirectional SBS gain versus dual SBS gain of the same fiber length.

Fabrication of elliptical-silica microfiber for ultrasound detection.

Elliptical shape microfiber enables many higher order modes compared with a circular microfiber. The small difference in the optical path length among many modes enabled multi-resonance peaks with high contrast in Mach-Zehnder (MZI) interferometers, which allows a large dynamic range and minimum detection sensitivity for broadband ultrasound sensing. In this paper, we present the design and fabrication of an ultra-compact elliptical-silica microfiber utilizing off-axis flame-drawing for ultrasound detection.

Cigarette tar accelerates atherosclerosis progression via RIPK3-dependent necroptosis mediated by endoplasmic reticulum stress in vascular smooth muscle cells.

Background: Tar is the main toxic of cigarettes, and its effect on atherosclerosis progression and the underlying mechanisms remain largely unknown. Vascular smooth muscle cells (VSMCs) play a key role in atherogenesis and plaque vulnerability. The present study sought to investigate the mechanism of atherosclerosis progression through tar-induced VSMC necroptosis, a recently described form of necrosis.

Association between fasting stress hyperglycemia ratio and contrast-induced acute kidney injury in coronary angiography patients: a cross-sectional study.

Aims: Stress hyperglycemia ratio (SHR), an emerging indicator of critical illness, exhibits a significant association with adverse cardiovascular outcomes. The primary aim of this research endeavor is to evaluate the association between fasting SHR and contrast-induced acute kidney injury (CI-AKI).

Methods: This cross-sectional study comprised 3,137 patients who underwent coronary angiography (CAG) or percutaneous coronary intervention (PCI).

A random optical parametric oscillator.

Synchronously pumped optical parametric oscillators (OPOs) provide ultra-fast light pulses at tuneable wavelengths. Their primary drawback is the need for precise cavity control (temperature and length), with flexibility issues such as fixed repetition rates and marginally tuneable pulse widths. Targeting a simpler and versatile OPO, we explore the inherent disorder of the refractive index in single-mode fibres realising the first random OPO - the parametric analogous of random lasers.

Apigenin inhibits macrophage pyroptosis through regulation of oxidative stress and the NF-κB pathway and ameliorates atherosclerosis.

Pyroptosis plays an important role in inflammatory diseases such as viral hepatitis and atherosclerosis. Apigenin exhibits various bioactivities, particularly anti-inflammation, but its effect on pyroptosis remains unclear. The aim of this study is to investigate the effect of apigenin on pyroptosis and explore its potential against inflammatory diseases.

Combining metabolomics and OCT to reveal plasma metabolic profiling and biomarkers of plaque erosion and plaque rupture in STEMI patients.

Objective: Plaque erosion (PE) and plaque rupture (PR) are the main subtypes of ST-segment elevation myocardial infarction (STEMI), the differences of metabolic patterns between PE and PR remain largely unknown.

Methods: 132 STEMI patients were divided into training set (PR, n = 36; PE, n = 36) and test set (PR, n = 30; PE, n = 30), the plasma from patients were analyzed by liquid chromatography quadruple time-of-flight mass spectrometry.

Results: We identified 56 and 28 differences in training and test set, respectively.

Homocysteine promotes atherosclerosis through macrophage pyroptosis via endoplasmic reticulum stress and calcium disorder.

Background: Elevated plasma homocysteine levels, known as hyperhomocysteinemia, have been identified as an independent risk factor for atherosclerosis and related cardiovascular diseases. Macrophage pyroptosis-mediated inflammation is crucial in the development of atherosclerosis, but the underlying mechanisms remain unclear.

Methods: A hyperhomocysteinemia atherosclerotic model with ApoE mice fed with a high-methionine diet was constructed to investigate the role of plasma homocysteine in atherosclerosis.

Estrogen deficiency accelerates postmenopausal atherosclerosis by inducing endothelial cell ferroptosis through inhibiting NRF2/GPX4 pathway.

Oxidative stress and lipid metabolism disorder caused by estrogen deficiency are regarded as the main causes of postmenopausal atherosclerosis, but the underlying mechanisms remain still unclear. In this study, ovariectomized (OVX) female ApoE mice fed with high-fat diet were used to imitate postmenopausal atherosclerosis. The atherosclerosis progression was significantly accelerated in OVX mice, accompanied by the upregulation of ferroptosis indicators, including increased lipid peroxidation and iron deposition in the plaque and the plasma.

Orthogonal polarization multi-wavelength Brillouin random fiber laser with triple Brillouin frequency shift space.

A novel multi-wavelength Brillouin random fiber laser with the channel space of triple Brillouin frequency shift and high polarization orthogonality between adjacent wavelengths (TOP-MWBRFL), to the best of our knowledge, is experimentally demonstrated. The TOP-MWBRFL is structured in a ring form by cascading two Brillouin random cavities of single-mode fiber (SMF) and one Brillouin random cavity of polarization-maintaining fiber (PMF). Based on polarization pulling properties of stimulated Brillouin scattering in long-distance SMFs and PMFs, the states of polarization (SOPs) of lasing light from SMF random cavities are linearly bounded to the SOPs of local pump light, whereas the SOP of lasing light from the PMF random cavity is strictly clamped on one of the principal axes of the PMF.

Self-injection locking of a low-noise erbium-doped random fiber laser by a random fiber grating ring.

We demonstrate a self-injection locking (SIL) in an Er-doped random fiber laser by a high quality factor (high-Q) random fiber grating ring (RFGR) resonator, which enables a single-mode narrow-linewidth lasing with ultra-low intensity and frequency noise. The RFGR resonator includes a fiber ring with a random fiber grating to provide random feedback modes and noise suppression filters with self-adjusted peak frequency adaptable to small perturbations allowing single longitudinal mode over 7000 s with frequency jitter below 3.0 kHz.

Cigarette tar mediates macrophage ferroptosis in atherosclerosis through the hepcidin/FPN/SLC7A11 signaling pathway.

Despite the known promotional effects of cigarette smoking on progression of atherosclerosis (AS), tar as the most dominant toxic component in cigarette smoking has been little studied. Understanding the potential role and mechanisms of tar in AS may be a prerequisite for future reductions in cardiovascular morbidity and mortality. Male ApoE mice were fed with high-fat diet and injected intraperitoneally with cigarette tar (40 mg/kg/day) for 16 weeks.

Distributed Impact Wave Detection in Steel I-Beam with a Weak Fiber Bragg Gratings Array.

In this paper, acoustic, dynamic and static strain variations along a steel I-beam generated by an impact load are reconstructed simultaneously within a single measurement. Based on the chirped pulse φ-OTDR system with the single-shot measurement technique, both a higher strain-sensing resolution and a higher measurable vibration frequency are achieved. In addition, a weak fiber Bragg gratings array (WFBGA) with enhanced Rayleigh reflection is employed as a sensor, providing high signal-to-noise ratio Rayleigh traces, resulting in lower measurement uncertainty.

Oxidative Stress-Mediated Programmed Cell Death: a Potential Therapy Target for Atherosclerosis.

Nowadays, as a type of orderly and active death determined by genes, programmed cell death (PCD), including apoptosis, pyroptosis, ferroptosis, and necroptosis, has attracted much attention owing to its participation in numerous chronic cardiovascular diseases, especially atherosclerosis (AS), a canonical chronic inflammatory disease featured by lipid metabolism disturbance. Abundant researches have reported that PCD under distinct internal conditions fulfills different roles of atherosclerotic pathological processes, including lipid core expansion, leukocyte adhesion, and infiltration. Noteworthy, emerging evidence recently has also suggested that oxidative stress (OS), an imbalance of antioxidants and oxygen free radicals, has the potential to mediate PCD occurrence via multiple ways, including oxidization and deubiquitination.

All-optical polarimeter for laser Stokes vector measurement using self-induced nonlinear phase modulation.

This paper utilizes an analytical model of polarization dependent frequency sideband generation via the Kerr effect in a highly nonlinear fiber to determine the state of polarization (SOP) of a laser by all-optical means. Theoretical analysis shows that the power of the n order sideband generated by the propagation of two lasers with distinct frequencies in the nonlinear medium is proportional to cos (α/2), where α is the angle between the normalized Stokes vectors representing the SOPs of the lasers on the Poincaré sphere. By tailoring the SOP of one laser acting as a reference and experimentally measuring the power of the first order sideband, the SOP of the laser under test is recovered with an error smaller than 10.

A novel anti-atherosclerotic mechanism of quercetin: Competitive binding to KEAP1 via Arg483 to inhibit macrophage pyroptosis.

Natural antioxidants represented by quercetin have been documented to be effective against atherosclerosis. However, the related mechanisms remain largely unclear. In this study, we identified a novel anti-atherosclerotic mechanism of quercetin inhibiting macrophage pyroptosis by activating NRF2 through binding to the Arg483 site of KEAP1 competitively.

Distributed birefringence sensing at 10 accuracy over ultra-long PMF by optical frequency comb and distributed Brillouin amplifier.

Brillouin dynamic gratings (BDG) can measure the distributed birefringence of polarization-maintaining fibers (PMF), however, its sensing range is limited by both stimulated Brillouin scattering depletion and fiber losses in PMF, which are significantly higher than those in standard single-mode fibers. In this work, we theoretically and experimentally verify that BDG can be sustained over ultra-long distances when assisted by distributed Brillouin amplification, significantly extending the distributed birefringence measurement distance. Using an optical frequency comb pumped by a narrow linewidth laser to both generate and interrogate the amplified BDG, a birefringence measurement accuracy of 7.

Stabilizing Brillouin random laser with photon localization by feedback of distributed random fiber grating array.

Strong scattering random media can localize light and extend photon lifetime through multiple scattering, which offers opportunities for stabilizing random lasers. Here, we demonstrate a frequency stabilized Brillouin random laser with high coherence enabled by photon localization in random fiber grating array (RFGA). Photon trapping is realized due to wave interference in multi-scattering Fabry-Pérot (FP) cavities between random fiber gratings enabling light localization to prolong photon lifetime.

Distributed temperature profile in hydrogen flame measured by telecom fiber and its durability under flame by OFDR.

The distributed temperature profile of hydrogen flame based on optical frequency-domain reflectometry (OFDR) was experimentally demonstrated for the first time. Spatial temperature field at different flow rate of H flame was monitored by OFDR via a telecom fiber (Corning SMF-28, CPC6) inside the flame over seconds, and the highest temperature is on the sides of center flame separated by ∼1.4mm with difference of 140∼190°C over the flame dimension of 2.

Generation of high performance optical chirped pulse for distributed strain sensing application with high strain accuracy and larger measurement range.

A photonic approach for generating low frequency drifting noise, arbitrary and large frequency chirping rate (FCR) optical pulses based on the Kerr effect in the nonlinear optical fiber is theoretically analyzed and experimentally demonstrated. Due to the Kerr effect-induced sinusoidal phase modulation in the nonlinear fiber, high order Kerr pulse with a large chirping rate is generated. In the concept-proof experiments, the FCR of the m Kerr pulse has been significantly improved by a factor of 2m+1.