Superhydrophilic Fluorinated Polymer Probe for Zero-Background F MRI with Adaptable Targeting Ability.

F magnetic resonance imaging (F MRI), with zero background, high tissue penetration depth, excellent spatial resolution, and nonradioactive features, has attracted considerable attention but faces tough challenges due to the shortage of sensitive and selective targetable probes. Herein, we report a biocompatible and highly sensitive F MRI probe with an adaptable tumor-targeting ability. The fluorine-grafted polymer (PIBMA-F) probes were rich with sulfoxide and carboxy groups, containing a high fluorine content (∼17 wt %).