Fluorescent poly(tannic acid)-based nanoprobes for selective and sensitive detection of bismuth ions.

Herein, blue luminescent fluorescent poly(tannic acid) nanoparticles (FPTA NPs) were fabricated through chemical degradation of poly(tannic acid) large particles using HO, and the obtained FPTA NPs exhibited excellent water dispersibility, great fluorescence stability, and relatively high quantum yield. More importantly, based on the dynamic quenching and chelation enhanced quenching effect between FPTA NPs and bismuth ions (Bi), a fluorescence method for the rapid identification and detection of Bi was developed. With the increase of Bi, the fluorescence of FPTA NPs could be quenched gradually; the linear range was 0.

Physiological energetics of selectively bred oysters (Crassostrea hongkongensis) under marine heatwaves.

Marine heatwaves (MHWs) have become more frequent and intense in the context of rapid climate change, causing detrimental effects on marine bivalves and ecosystems they sustain. While selective breeding programs for bivalves can substantially enhance growth performance, their ability to improve thermal stress tolerance remains largely unexplored. Here, we compared physiological energetics of wild and selectively bred Hongkong oysters (Guihao No.

Terrestrial dissolved organic matter inputs affect the nitrous oxide emission revealed by FT-ICR MS.

Nitrous oxide (NO) emission from lake systems could be affected via intrusion of terrestrial organic matter, causing impairment in biogeochemical cycling. The sources and mechanisms by which DOM (Dissolved organic matter) alters emissions of NO are poorly understood. Here, we simulate different terrestrial DOM (anthropogenic sources, natural sources, and surface runoff) to assess the mechanisms affecting NO emissions with variations of DOM.

CAF-derived miR-642a-3p supports migration, invasion, and EMT of hepatocellular carcinoma cells by targeting SERPINE1.

Background: Cancer-associated fibroblasts (CAFs) and hepatocellular carcinoma (HCC) cells interact to promote HCC progression, but the underlying mechanisms remain unclear. Serpin family E member 1 (SERPINE1) has conflicting roles in HCC, and microRNAs (miRNAs) are known to regulate tumor progression through intercellular communication. Therefore, we investigated the potential involvement of miRNA/SERPINE1 axis in crosstalk between CAFs and HCC cells.

Circulating metabolome in relation to cognitive impairment: a community-based cohort of older adults.

The role of circulating metabolome in cognitive impairment is inconclusive, and whether the associations are in the severity-dependent manner remains unclear. We aimed to identify plasma metabolites associated with cognitive impairment and evaluate the added predictive capacity of metabolite biomarkers on incident cognitive impairment beyond traditional risk factors. In the Rugao Longevity and Ageing Study (RuLAS), plasma metabolome was profiled by nuclear magnetic resonance spectroscopy.

Lack of retinal degeneration in a Dram2 knockout mouse model.

Damage-regulated autophagy modulator 2 (DRAM2) is a homologue of the DRAM family protein, which can induce autophagy process. In the retina, DRAM2 is located to the inner segment of photoreceptors, the apical surface of retinal pigment epithelial (RPE) cells, and the lysosome. Pathogenic variants of DRAM2 lead to autosomal recessive Cone-rod dystrophy 21 (CORD21).

Metrics of Physiological Network Topology Are Novel Biomarkers to Capture Functional Disability and Health.

Background: Physiological networks are highly complex, integrating connections among multiple organ systems and their dynamic changes underlying human aging. It is unknown whether individual-level network could serve as robust biomarkers for health and aging.

Methods: We used personalized network analysis to construct a single-sample network and examine the associations between network properties and functional disability in the Rugao Longevity and Aging Study (RuLAS), the China Health and Retirement Longitudinal Study (CHARLS), the Chinese Longitudinal Healthy Longevity Survey (CLHLS), and the National Health and Nutrition Examination Survey (NHANES).

Effects of Family Audio Recordings on Depression, Cognitive Function, and Sleep Quality of Individuals With Alzheimer's Disease: A Randomized Controlled Trial.

Purpose: To explore the effects of family audio recordings on depression, cognitive function, and sleep quality among individuals with Alzheimer's disease in nursing homes.

Method: A randomized controlled study design was used, and 107 participants with Alzheimer's disease were stratified and randomly assigned to groups based on Clinical Dementia Rating Scale scores. The control group received usual care and health education, and the experimental group received usual care, health education, and a family audio recording intervention.

Deletion of Transmembrane protein 184b leads to retina degeneration in mice.

Transmembrane protein 184b (Tmem184b) has been implicated in axon degeneration and neuromuscular junction dysfunction. Notably, Tmem184b exhibits high expression levels in the retina; however, its specific function within this tissue remains poorly understood. To elucidate the role of Tmem184b in the mammalian visual system, we developed a Tmem184b knockout (KO) model for further investigation.

Lipopolymer/siRNA Nanoparticles Targeting the Signal Transducer and Activator of Transcription 5A Disrupts Proliferation of Acute Lymphoblastic Leukemia.

The therapeutic potential of small interfering RNAs (siRNAs) in gene-targeted treatments is substantial, but their suboptimal delivery impedes widespread clinical applications. Critical among these is the inability of siRNAs to traverse the cell membranes due to their anionic nature and high molecular weight. This limitation is particularly pronounced in lymphocytes, which pose additional barriers due to their smaller size and scant cytoplasm.

Gonadal rematuration and sex-specific reproductive impairment in Manila clams under ocean acidification.

Ocean acidification (OA) can affect marine bivalves at various levels of biological organization. Yet, little effort has been devoted to understanding how OA affects the reproductive events of marine bivalves during multiple cycles of maturation. Here, we tested sex-specific reproductive responses of Manila clams (Ruditapes philippinarum) to OA during gonadal rematuration.

Lipopolymer/siRNA complexes engineered for optimal molecular and functional response with chemotherapy in FLT3-mutated acute myeloid leukemia.

Approximately 25% of newly diagnosed AML patients display an internal tandem duplication (ITD) in the fms-like tyrosine kinase 3 (FLT3) gene. Although both multi-targeted and FLT3 specific tyrosine kinase inhibitors (TKIs) are being utilized for clinical therapy, drug resistance, short remission periods, and high relapse rates are challenges that still need to be tackled. RNA interference (RNAi), mediated by short interfering RNA (siRNA), presents a mechanistically distinct therapeutic platform with the potential of personalization due to its gene sequence-driven mechanism of action.

Bivalves under extreme weather events: A comparative study of five economically important species in the South China sea during marine heatwaves.

Marine heatwaves (MHWs) are increasing in frequency and intensity, threatening marine organisms and ecosystems they support. Yet, little is known about impacts of intensifying MHWs on ecologically and economically important bivalves cultured in the South China Sea. Here, we compared survival and physiological responses of five bivalve species, Pinctada fucata, Crassostrea angulata, Perna viridis, Argopecten irradians and Paphia undulata, to two consecutive MHWs events (3 days of thermal exposure to + 4 °C or + 8 °C, following 3 days of recovery under ambient conditions).

Assembling of Nitropyrazoles into Tetranitroacetimidic Acid (TNAA): A Pathway to High-Performance Energetic Oxidizers through Dual C/N-Functionalization.

In this work, incorporating nitropyraozles into tetranitroacetimidic acid () resulted in two analogues of isomeric TNAA-like compounds ( and ). These compounds exhibit excellent densities, detonation performance, and high specific impulse, which are promising high-energy oxidizers that are comparable to and . This structural modification strategy may have the potential to contribute significantly to the development of versatile, high-performance energetic oxidizers.

Environmental and social framework to protect marine bivalves under extreme weather events.

Rising ocean temperatures, a consequence of anthropogenic climate change, are increasing the frequency, intensity, and magnitude of extreme marine heatwaves (MHWs). These persistent anomalous warming events can have severe ecological and socioeconomic impacts, threatening ecologically and economically vital organisms such as bivalves and the ecosystems they support. Developing robust environmental and social frameworks to enhance the resilience and adaptability of bivalve aquaculture is critical to ensuring the sustainability of this crucial food source.

EPHB2 Knockdown Mitigated Myocardial Infarction by Inhibiting MAPK Signaling.

Myocardial infarction (MI) is a common type of cardiovascular disease. The incidence of ventricular remodeling dysplasia and heart failure increases significantly after MI. The objective of this study is to investigate whether erythropoietin hepatocellular receptor B2 (EPHB2) can regulate myocardial injury after MI and explore its regulatory pathways.

CSTF3 contributes to platinum resistance in ovarian cancer through alternative polyadenylation of lncRNA NEAT1 and generating the short isoform NEAT1_1.

Platinum-based chemotherapy is the standard postoperative adjuvant treatment for ovarian cancer (OC). Despite the initial response to chemotherapy, 85% of advanced OC patients will have recurrent disease. Relapsed disease and platinum resistance are the major causes of death in OC patients.

A bulit-in self-calibration ratiometric self-powered photoelectrochemical sensor for high-precision and sensitive detection of microcystin-RR.

A novel high-precision aptasensor of microcystin-RR (MC-RR) is developed based on a ratiometric self-powered photoelectrochemical platform. In detail, the defective MoS/TiC nanocomposite with good photoelectric activity was designed to serve as the photoanode of the sensor for enhancing the signal and improving the detection sensitivity. In order to effectively eliminate external interferences, the key point of this ratiometric device is the introduction of the spatial-resolved technique, which includes the detection section and the reference section, generating reference signals and response signals, respectively.