Dominant species modulates nitrogen effects on the temporal stability of above- and below-ground biomass in a temperate desert steppe.

The temporal stability of above-ground biomass (AGB) and below-ground biomass (BGB) in grasslands is crucial for maintaining a continuous supply of ecosystem functions and services, particularly in the context of global changes. Nitrogen (N) addition is well known to affect AGB stability, however, we still lack knowledge of how N addition affect BGB stability. Furthermore, a crucial knowledge gap remains regarding which underlying mechanisms drive AGB and BGB stability, which obstructs our comprehensive awareness of biomass stability from both above- and below-ground perspectives simultaneously.

ORP5 promotes cardiac hypertrophy by regulating the activation of mTORC1 on lysosome.

Introduction: Oxysterol binding protein (OSBP)-related protein 5 (ORP5) mainly functions as a lipid transfer protein at membrane contact sites (MCS). ORP5 facilitates cell proliferation through the activation of mTORC1 signaling. While the pro-hypertrophic effects of mTORC1 are well-documented, the specific role of ORP5 in the context of pathological cardiac hypertrophy remains inadequately understood.

Contrast-Enhanced Computed Tomography Radiomics Predicts Colony-Stimulating Factor 3 Expression and Clinical Prognosis in Ovarian Cancer.

Rationale And Objectives: To develop a radiomics model for non-invasive prediction of colony-stimulating factor 3 (CSF3) expression in ovarian cancer (OC) and evaluate its prognostic value.

Materials And Methods: We acquired clinical data, genetic information, and corresponding computed tomography (CT) scans of OC from The Cancer Genome Atlas and The Cancer Imaging Archive repositories. We assessed the prognostic significance of CSF3 and its association with clinical features through the utilization of Kaplan-Meier analysis, univariate and multivariate Cox regression analysis, along with subgroup analysis.

Ellagic acid-based non-isocyanate polyurethane water-soluble sizing agents for enhancing the interfacial properties of carbon fiber/epoxy composites.

The preparation of environmentally friendly and efficient waterborne polyurethane sizing agents for carbon fiber (CF) is difficult, especially to avoid the use of isocyanates. Herein, ellagic acid and CO were used to prepare a five-membered cyclic carbonate compound (EARBO). The polymerization between EARBO and diamines enabled the preparation of highly efficient and green aqueous non-isocyanate polyurethane (WNIPU) sizing agents.

Rumen microbiome and fat deposition in sheep: insights from a bidirectional mendelian randomization study.

Rumen microbiotas are known to influence the fat deposition (FD) in sheep, but controversy over causality remains unresolved. Here, we performed microbiome-wide association studies (MWAS), microbiome genome-wide association analysis (mbGWAS) and bidirectional mendelian randomization (MR) analyses on 1,150 sheep with genotype data from whole-genome resequencing, 16S rRNA sequencing and multilevel FD-traits data. We quantified the proportion of individual variation in FD-traits explained by host genetics, rumen microbiota, and their interaction effects.

Correlation Between Symptom Clusters and Self-Management Among Maintenance Haemodialysis Patients: A Cross-Sectional Study.

Aims And Objectives: The purpose of this study was to explore the relationship between symptom clusters and self-management among maintenance haemodialysis (MHD) patients.

Background: MHD patients experience disease progression and multiple symptom burdens that severely impact quality of life, and self-management of symptoms may significantly improve patient-reported outcomes.

Design: A cross-sectional study.

Assist me or replace me? Uncovering the influence of AI awareness on employees' counterproductive work behaviors.

Objective: Drawing on the conservation of resources theory (COR), the research aims to reveal the influence of artificial intelligence (AI) awareness on employees' mental health and behaviors, particularly examining whether and how employees' AI awareness impacts their counterproductive work behaviors (CWB) in human-intelligence collaborations.

Methods: Data was collected from 327 Chinese employees who collaborated with AI in sales, manufacturing, logistics, and other industries. The measurement instruments included scales for AI awareness, psychological contract (PC), emotional exhaustion (EE), and counterproductive work behavior (CWB).

Genome-Wide Association Study on Body Conformation Traits in Xinjiang Brown Cattle.

Body conformation traits are linked to the health, longevity, reproductivity, and production performance of cattle. These traits are also crucial for herd selection and developing new breeds. This study utilized pedigree information and phenotypic (1185 records) and genomic (The resequencing of 496 Xinjiang Brown cattle generated approximately 74.

Potential diagnostic value of circulating miRNAs in HFrEF and bioinformatics analysis.

Background: Few studies have compared the performances of those reported miRNAs as biomarkers for heart failure with reduced EF (HFrEF) in a population at high risk. The purpose of this study is to investigate comprehensively the performance of those miRNAs as biomarkers for HFrEF.

Methods: By using bioinformatics methods, we also examined these miRNAs' target genes and possible signal transduction pathways.

The impact of work-family conflict on Chinese women's fertility intention: the role of fertility attitude, income class, and child-rearing burden.

The struggle women face in balancing work and family roles is a significant factor contributing to the decline in their fertility intentions. Therefore, work-family conflict serves as a crucial determinant influencing women's fertility intentions. This study aims to explore the internal mechanism between work-family conflict and the fertility intentions of Chinese women, using data obtained from 334 questionnaires.

Streamlined process for effective and strand-selective mitochondrial base editing using mitoBEs.

Mitochondrial base editing tools hold great promise for the investigation and treatment of mitochondrial diseases. Mitochondrial DNA base editors (mitoBEs) integrate a programmable transcription-activator-like effector (TALE) protein with single-stranded DNA deaminase (TadA8e-V106W, APOBEC1, .) and nickase (MutH, Nt.

The diagnostic value of serum trefoil factor 3 and pepsinogen combination in chronic atrophic gastritis: a retrospective study based on a gastric cancer screening cohort in the community population.

Background: Chronic atrophic gastritis (CAG) is an important precursor of gastric cancer(GC), and there is currently a lack of reliable non-invasive diagnostic markers. This study aims to find a biomarker for non-invasive screening of CAG in the community.

Methods: A total of 540 individuals were enrolled (test set = 385, validation set = 155).

Alternative Splicing in Glioblastoma and its Clinical Implication in Outcome Prediction.

Background And Objective: Alternative splicing (AS) offers an important mechanism to form protein polymorphism. A growing body of evidence indicates the correlation between splicing abnormality and carcinoma. Nevertheless, an overall analysis of AS signatures in glioblastoma (GBM) is absent and urgently needed.

A Pan-Cancer Analysis of the Oncogenic Role of Methyltransferase-Like 1 in Human Tumors.

Background And Object: Although emerging cell- or animal-based evidence supports the relationship between methyltransferase-like 1 (METTL1) and cancers, no pan-cancer analysis is available.

Methods: We thus first explored the potential oncogenic roles of METTL1 across 33 tumors based on the datasets of The Cancer Genome Atlas and Gene Expression Omnibus.

Results: METTL1 is highly expressed in most cancers, and distinct associations exist between METTL1 expression and prognosis of tumor patients.

Identification and Prognostic Value of m6A-Related Genes in Glioblastoma.

Background: N6-methyladenosine (m6A) is one of the most common forms of mRNA modification, which is dynamically regulated by the m6A-related genes; however, its effect in glioblastoma (GBM) is still unknown.

Objective: We sought to investigate the association between m6A-related genes (m6A-RGs) and GBM.

Methods: Transcriptome data and the relevant clinical data were downloaded from The Cancer Genome Atlas and Gene Expression Omnibus databases.

Cardiac magnetic resonance imaging for discrimination of hypertensive heart disease and hypertrophic cardiomyopathy: a systematic review and meta-analysis.

Introduction: Differentiating hypertensive heart disease (HHD) from hypertrophic cardiomyopathy (HCM) is crucial yet challenging due to overlapping clinical and morphological features. Recent studies have explored the use of various cardiac magnetic resonance (CMR) parameters to distinguish between these conditions, but findings have remained inconclusive. This study aims to identify which CMR parameters effectively discriminate between HHD and HCM and to investigate their underlying pathophysiological mechanisms through a meta-analysis.

Programmable DNA pyrimidine base editing via engineered uracil-DNA glycosylase.

DNA base editing technologies predominantly utilize engineered deaminases, limiting their ability to edit thymine and guanine directly. In this study, we successfully achieve base editing of both cytidine and thymine by leveraging the translesion DNA synthesis pathway through the engineering of uracil-DNA glycosylase (UNG). Employing structure-based rational design, exploration of homologous proteins, and mutation screening, we identify a Deinococcus radiodurans UNG mutant capable of effectively editing thymine.