Publications by authors named "Xiaoxue Tian"
Metastatic SMARCA4-deficient undifferentiated tumor in the small mesentery: case report.
World J Surg Oncol
December 2024
Background: SMARCA4-deficient undifferentiated tumor (SMARCA4-UT) is a rare and highly malignant primary tumor characterized by the loss of SMARCA4 expression. Despite advancements in oncology, diagnosing and treating SMARCA4-UT remain significant clinical challenges.
Case Demonstration: A 67-year-old male with a history of smoking presented to the hospital with complaints of abdominal distention and pain lasting for more than four days.
Article Synopsis
- Intrahepatic cholestasis of pregnancy (ICP) is a liver disease diagnosed mainly by serum total bile acid levels, but this method lacks sensitivity and specificity.
- Recent research identifies lactate dehydrogenase A (LDHA) as a potential new biomarker, which is highly expressed in ICP patients and detected using DIA proteomic technology.
- A study developed a novel immunochromatographic test strip to quantitatively measure LDHA levels and explored its role in the inflammatory mechanisms of ICP, suggesting LDHA may be a promising target for improved diagnosis and treatment strategies.
Background: The coexistence of two or more distinct neoplasms within the same anatomical site characterizes collision tumors. While the presence of dual tumors is frequently observed in esophageal cases, the simultaneous occurrence of three distinct tumor types is extremely rare, posing significant challenges for pathological evaluation and diagnosis. Surgical resection remains the primary treatment, with generally favorable outcomes.
View Article and Find Full Text PDFPurpose: This study aims to evaluate the diagnostic efficacy of F-fibroblast activation protein inhibitor-04 (F-FAPI-04) PET/CT for various malignant tumors and compare it head-to-head with F-FDG PET/CT.
Materials And Methods: This single-center, prospective study continuously recruited patients with suspected or confirmed malignant tumors for concurrent 18F-FDG and 18F-FAPI-04 PET/CT scans from April 2022 to October 2023. The pathological diagnosis or clinical follow-up served as the reference standard.
Myopia, a prevalent refractive error, primarily affects children and adolescents, characterized by excessive axial elongation causing distant objects to focus in front of the retina. This review explores the intricate mechanisms beyond intraocular factors, emphasizing the significant role of central factors in myopia development and progression. Intraocular mechanisms involving the retina, RPE/choroid, and sclera are well documented, with these structures playing crucial roles in eye growth regulation.
View Article and Find Full Text PDFA simple goiter of the right ventricle: case report and literature review.
Front Cardiovasc Med
November 2024
Article Synopsis
- Cardiac teratomas are rare, making up less than 1% of adult heart tumors, with the intracardiac variety being even more uncommon, posing diagnosis and treatment challenges.* -
- A 50-year-old man diagnosed with a right ventricular teratoma was successfully treated; imaging techniques revealed a significant mass, and surgery led to a good recovery with no recurrence in 2 years.* -
- Intracardiac teratomas are mostly benign tumors, primarily affecting the right ventricle, and effective treatment through surgical removal often results in a positive outcome.*
Recent outbreaks of alarming bacterial diseases have significantly impacted global agricultural productivity. Conventional bactericides exhibit certain limitations in efficiently impeding biofilm formation and annihilating biofilm-dispersed pathogens, and often expose to high off-target movement during foliar spraying. Here, we produce an innovative helical dendrimer-like supramolecular material (PhA28@β-CD) assembled by a bioactive small-molecule 2-chlorophenylisopropanolamine (PhA28) and β-cyclodextrin (β-CD) through host-guest recognition principle.
View Article and Find Full Text PDFBackground: Myoepithelial carcinoma (MECA) is a malignant tumor primarily affecting the salivary gland, most frequently in the parotid gland. It can manifest as primary or secondary to pleomorphic adenoma or benign myoepithelioma. MECA exhibits aggressive behaviors.
View Article and Find Full Text PDFBackground: Endometrial stromal sarcoma (ESS) is a rare type of uterine malignancy typically classified into low-grade ESS (LG-ESS) and high-grade ESS. LG-ESS is characterized by low malignancy and limited metastasis, primarily to the lungs. Metastasis of the breast is extremely rare, posing significant challenges in clinical diagnosis and treatment.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the expression patterns and prognostic significance of PLOD family genes in breast cancer, revealing that PLOD1 and PLOD3 are upregulated in cancerous tissues.
- High levels of these genes are linked to worse survival rates and are particularly elevated in younger patients and those with aggressive forms like triple negative breast cancer (TNBC).
- Findings suggest that PLOD family genes could serve as potential prognostic biomarkers and that targeting PLOD inhibitors may offer a new treatment approach for breast cancer.
Background: Early diagnosis of HIV infection decreases the time from HIV diagnosis to viral suppression and reduces further HIV transmission. The Chinese Guidelines for the Diagnosis and Treatment of HIV/AIDS (2021 edition) state that an HIV RNA level > 5,000 copies/mL is the threshold for diagnosing HIV infection. The impact of low viral load values on HIV diagnosis needs to be investigated.
View Article and Find Full Text PDFArticle Synopsis
- The study focuses on Vessels encapsulating tumor clusters (VETC) in hepatocellular carcinoma (HCC), which indicate a poor prognosis, and aims to create a nomogram model that predicts these patterns based on preoperative CT scans.
- Researchers analyzed data from 84 patients who had surgical resections, identifying key predictors of VETC patterns through logistic regression, and developed a nomogram model that achieved a prediction accuracy (AUC) of 0.767.
- The study found that certain factors like AST/ALT ratio, intratumoral necrosis, and the presence of an enhancing capsule were significant predictors of VETC patterns, while CK19 status, number of tumors, and VETC patterns
Article Synopsis
- - The study focuses on the role of leukaemia stem cells (LSCs) in the aggressiveness of mixed-lineage leukaemia (MLL) rearranged acute myeloid leukaemia (AML) and explores the interaction between the DNA damage response (DDR) and DOT1L/H3K79me pathways in maintaining LSCs.
- - It was found that the enzyme ATM (part of the DDR) regulates LSC maintenance through a series of protein modifications, which includes phosphorylating CBP, helping it avoid degradation, and subsequently, acetylating DOT1L to boost expression of leukaemia-related genes.
- - Interestingly, the ATM's regulatory effects on the CBP-DOT1
Article Synopsis
- Vessels encapsulating tumor clusters (VETC) in hepatocellular carcinoma (HCC) are linked to worse patient outcomes, and this study aims to predict this pattern using preoperative Gd-EOB-DTPA MRI imaging.
- The study evaluated 98 HCC patients and identified three key predictors of VETC: peritumoral hypointensity on the hepatobiliary phase, low tumor-to-liver signal intensity ratio, and low tumor-to-liver apparent diffusion coefficient ratio.
- A nomogram was created from these predictors, achieving moderate accuracy, and both VETC pattern and Barcelona Clinic Liver Cancer stage were shown to significantly affect recurrence-free survival after surgery.
Article Synopsis
- Studies indicate that vessels encapsulating tumor clusters (VETC) can predict the prognosis for patients with hepatocellular carcinoma (HCC).
- A meta-analysis of thirteen studies involving 4429 patients found that VETC is significantly linked to worse overall survival (OS) and tumor efficacy (TE), with specific hazard ratios indicating higher risks of recurrence.
- The findings support VETC as a valuable prognostic indicator for HCC patients, suggesting that those with VETC have lower survival rates and higher recurrence risks.
Article Synopsis
- Peroxynitrite (ONOO) is a reactive nitrogen/oxygen species linked to biological processes like cell death and is elevated in tumors, correlating with oxidative stress levels.
- The herbicide paraquat (PQ) has been shown to significantly increase ONOO levels in cells, highlighting the importance of monitoring ONOO for diagnosing and treating oxidative stress-related diseases.
- Researchers developed a chemiluminescent probe (CL-1) that is highly sensitive and effective for detecting ONOO, outperforming traditional fluorescent probes, and showing potential for biological imaging in tumor pathology and other applications.
As an essential factor in the prognosis of systemic lupus erythematosus (SLE), lupus nephritis (LN) can accelerate the rate at which patients with SLE can transition to chronic kidney disease or even end-stage renal disease. Podocytes now appear to be a possible direct target in LN in addition to being prone to collateral damage from glomerular capillary lesions induces by immune complexes and inflammatory processes. The NLRP3 inflammasome is regulated by CCAAT/enhancer-binding protein β (C/EBPβ), which is involved in the pathogenesis of SLE.
View Article and Find Full Text PDFThiol-Chromene "Click" Reaction-Activated Chemiluminescent Probe for Thiol Detection In Vitro and In Vivo.
ACS Appl Mater Interfaces
July 2023
Biothiols are biomolecules found in a higher content in cancer cells compared to normal cells, marking them useful cancer biomarkers. Chemiluminescence is widely used in biological imaging due to its excellent sensitivity and signal-to-noise ratio (SNR). In this study, we designed and prepared a chemiluminescent probe that is activated by a thiol-chromene "click" nucleophilic reaction.
View Article and Find Full Text PDFTapinarof is an aryl hydrocarbon receptor (AHR) ligand which is used to treat plaque psoriasis in adults. However, the underlying mechanism is not yet fully understood. In this study, we applied two of the most studied psoriasis mouse models: topical application of imiquimod (IMQ) and subcutaneous injection of IL-23.
View Article and Find Full Text PDFObjective: The best type of resuscitation fluids for sepsis and septic shock patients remains unclear. The aim of this study was to evaluate the efficacy of different concentrations of albumin on reducing the mortality rate of theses patients by meta-analysis.
Materials And Methods: PubMed, EMBASE, and Web of Science databases were used for screening the relevant studies.
Article Synopsis
- Research indicates that miR-21 is frequently found at abnormal levels in breast cancer patients, making it a potential diagnostic biomarker.
- The study conducted a comprehensive analysis of literature from various databases, assessing the quality of studies and using statistical tools to analyze the data.
- Findings from nine studies comprising 2,048 patients suggest that miR-21 has strong diagnostic value for breast cancer, with recommendations to enhance its effectiveness by combining it with other microRNAs.
Article Synopsis
- - The study aimed to assess the effectiveness of 6 imaging techniques in distinguishing glioma recurrence from changes post-radiotherapy by conducting a network meta-analysis based on direct comparison studies.
- - Researchers searched multiple databases and included 15 relevant articles to evaluate the diagnostic capabilities of various imaging modalities, with the F-FET technique showing the highest accuracy and sensitivity.
- - The findings suggest that F-FET and F-FDOPA are more valuable in diagnosing glioma recurrence compared to other methods, indicating a moderate quality of evidence overall.