Bond Behavior of Steel Bars in Concrete Confined with Stirrups under Freeze-Thaw Cycles.

In order to evaluate the influence of freeze-thaw action on the durability of concrete structures, this paper presented an experimental study to investigate the effects of freezing-thawing cycles and concrete strength on the bond behavior between steel bars and concrete confined with stirrups. Through freeze-thaw cycles and center pullout tests, the failure mode of pullout specimen, concrete strength, mass loss, dynamic elastic modulus, and bond-slip curves were analyzed. At last, the bond-slip constitutive model was proposed for specimens with stirrup confinement under freeze-thaw action.

Synthesis and biological evaluation of novel pyrimido[4,5-b]quinoline-2,4- dione derivatives as MDM2 ubiquitin ligase inhibitors.

A series of pyrimido[4,5-b]quinoline-2,4-dione derivatives was synthesized and evaluated for their cytotoxic activities in vitro against five human cancer cell lines. Selected compounds were tested for their MDM2 E3 ligase inhibitory activities and p53-MDM2 binding inhibitory activities. Among tested compounds, four sulfur-containing compounds (4-7) displayed enhanced cytotoxic activities and better MDM2 E3 ligase inhibitoty activities in comparison with that of HLI98c.

Design, synthesis and CoMFA studies of N1-amino acid substituted 2,4,5-triphenyl imidazoline derivatives as p53-MDM2 binding inhibitors.

A series of novel N1-amino-acid substituted 2,4,5-triphenyl imidazoline derivatives was designed and synthesized based on our previous studies. All synthesized target compounds were screened for their p53-MDM2 binding inhibitory activities and anti-proliferative activities against five cancer cell lines. Among them, twelve compounds displayed improved binding inhibitory activities and most compounds showed higher cell growth inhibition activities with IC(50) values in the low micromolar range.