Publications by authors named "Xiaoxin You"
Article Synopsis
- Long Interspersed Element 1 (L1) plays a crucial role in regulating the genome and evolution, and its expression is influenced by viral infections, affecting the host's immune response and disease progression.
- In the context of Epstein-Barr virus (EBV) and gastric cancer, research shows that EBV-associated gastric cancer (EBVaGC) exhibits decreased L1 transcription compared to EBV-negative gastric cancer (EBVnGC), particularly affecting young and full-length L1s (FL-L1s).
- The study suggests that increased H3K9me3 levels, linked to heightened TASOR expression, contribute to the repression of FL-L1s, demonstrating how EBV infection can reshape chromatin structure and
Repurposing Axl Kinase Inhibitors for the Treatment of Respiratory Syncytial Virus Infection.
Antimicrob Agents Chemother
March 2023
Article Synopsis
- - Respiratory syncytial virus (RSV) is a major cause of lung infections in infants and the elderly, but there are currently no specific treatments for it.
- - Researchers tested Axl inhibitors, which block a receptor involved in regulating the immune response, and found that they significantly reduced RSV infection in both cell cultures and animal models.
- - The study suggests that Axl inhibitors can enhance the body’s antiviral response, leading to increased immune activity and a reduction in virus levels and inflammation in the lungs.
Axl Mediates Resistance to Respiratory Syncytial Virus Infection Independent of Cell Attachment.
Am J Respir Cell Mol Biol
August 2022
Article Synopsis
- Respiratory syncytial virus (RSV) is a major cause of serious lung infections in infants and young kids, and Axl, a receptor protein, plays a role in this process.
- Research shows that Axl actually helps the virus by suppressing the body's antiviral defenses, as evidence from studies with human cells and Axl-deficient mice indicates increased resistance to RSV.
- The findings suggest that the Axl protein not only acts as a receptor for the virus but also inhibits important immune signaling pathways, which could impact how the body fights off RSV infections.
Ischemic stroke is a common cause of permanent disability in adults worldwide. Inflammation plays a significant role in the pathogenesis of ischemic stroke and its mechanism is complex. Both pro-inflammatory and anti-inflammatory mediators are involved in the pathogenesis of ischemic stroke, an imbalance of which leads to inflammation.
View Article and Find Full Text PDFBackground: Stroke is responsible for increasingly high rates of mortality and disability worldwide. Approximately two million people suffer from stroke for the first time in China each year. The high incidence (50%) of post-stroke disability brings a heavy burden to patients and their caregivers.
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