Association between psychological resilience and symptom burden in postoperative patients with brain gliomas and its influencing factors.

Objectives: This study aimed to explore the relationship between psychological resilience (PR) and symptom burden in postoperative brain glioma (BG) patients and to identify factors influencing this relationship.

Methods: A total of 296 postoperative BG patients were included in this study. Various scales were employed, including the General Information Questionnaire, the Psychological Resilience Scale for PR, the M.

Tunable Integrin-Ligand Coupling Strength Modulates Cellular Adaptive Mechanosensing.

Cells sense and respond to the matrix by exerting traction force through binding of integrins to an integrin-specific ligand. Here, Arg-Gly-Asp (RGD) peptide is covalently conjugated to the double-stranded DNA (dsDNA) and stem-loop DNA (slDNA) tethers with a tension tolerance of 43pN and immobilized on a PEG substrate. Unlike dsDNA, which is ruptured under high tension, leading to the removal of RGD, slDNA remains bound even when ruptured.

A flexible MRF approach to improve kinetic rate estimation with bSSFP-based hyperpolarized [1-C]pyruvate MRI.

Purpose: In this work, we adopt the MR fingerprinting (MRF) framework and leverage its flexibility in quantitative pulse sequence design to propose improved balanced steady-state free precession (bSSFP)-based hyperpolarized Carbon-13 (C) acquisitions for robust metabolic conversion rate quantification.

Methods: Spectrally selective bSSFP-based acquisitions with variable RF excitation were implemented for [1-C]pyruvate and used in conjunction with prior implementation of [1-C]lactate selective bSSFP imaging. MRF framework parameter estimation was performed using dictionary-based template matching.

Baicalin Decreases the LPS-Induced Intestine Inflammatory Responses by ROS/p-ERK/p-P38 Signal Pathways In Vivo and In Vitro.

This study aimed to investigate the role of ROS/MAPK signaling pathways and the effects of baicalin in LPS-induced inflammatory responses in and porcine intestinal epithelial cells (IPEC-J2). : In vivo, 18 male C57BL/6J were randomly divided into three groups ( = 6): control, LPS (3.5 mg/kg LPS administered intraperitoneally [ip] on day 7), and baicalin (200 mg/kg orally for 7 days, with LPS ip on day 7).

Analysis of factors influencing the relationship between voriconazole plasma concentrations and adverse effects in a paediatric population.

Aims: The influence of CYP2C19 polymorphisms on voriconazole plasma concentrations is recognized, but its extent, other contributing factors and risks for adverse reactions remain under-explored.

Methods: This study focused on Japanese paediatric patients recruited between 2020 and 2022 treated with voriconazole. We specifically investigated the occurrence of cholestasis and thrombocytopenia as adverse reactions of voriconazole.

A variant in HMMR/HMMR-AS1 is associated with serum alanine aminotransferase levels in the Ryukyu population.

The Ryukyu archipelago is located southwest of the Japanese islands, and people originally from this region, the Ryukyu population, have a unique genetic background distinct from that of other populations, including people from mainland Japan. However, few genetic studies have focused on the Ryukyu population. In this study, we performed genome-wide association studies (GWAS) on the serum levels of alanine aminotransferase (ALT, n = 15,224), aspartate aminotransferase (AST, n = 15,203), and gamma-glutamyl transferase (GGT, n = 14,496) in the Ryukyu population.

Effects of individualized comprehensive nutritional support on inflammatory markers, serum amylase (AMS), prealbumin (PA), albumin (ALB), calcium ion (Ca2+) in patients with severe pancreatitis.

Background: The aim of the paper was to study the effectiveness of individualized comprehensive nutritional support on inflammatory markers, serum amylase (AMS), prealbumin (PA), albumin (ALB), calcium ion (Ca2+) in patients with severe acute pancreatitis (SAP).

Methods: 102 participants with SAP treated in our hospital were chosen as the study objects. The participants were randomly split into a control group and an observation group and both groups were given routine treatment.

Induction of enhanced stem-directed neutralizing antibodies by HA2-16 ferritin nanoparticles with H3 influenza virus boost.

Current seasonal influenza vaccines offer limited protection against influenza viruses due to genetic drift. The urgent need for a universal influenza vaccine to combat highly mutated strains is evident. This study utilized the conserved HA2 subunit of hemagglutinin (HA) and a short linear epitope of HA2 (HA2-16) from the H3 influenza virus to conjugate with ferritin, resulting in the construction of recombinant immunogens termed HA2-F and HA2-16-F, respectively.

Butyrolactone-I from Marine Fungal Metabolites Mitigates Heat-Stress-Induced Apoptosis in IPEC-J2 Cells and Mice Through the ROS/PERK/CHOP Signaling Pathway.

Heat stress poses a significant challenge to animal husbandry, contributing to oxidative stress, intestinal mucosal injury, and apoptosis, which severely impact animal health, growth, and production efficiency. The development of safe, sustainable, and naturally derived solutions to mitigate these effects is critical for advancing sustainable agricultural practices. Butyrolactone-I (BTL-I), a bioactive compound derived from deep-sea fungi (Aspergillus), shows promise as a functional feed additive to combat heat stress in animals.

Population-specific reference panel improves imputation quality for genome-wide association studies conducted on the Japanese population.

To improve imputation quality for genome-wide association studies (GWAS) conducted on the Japanese population, we developed and evaluated four Japanese population-specific reference panels. These panels were constructed through the augmentation of the 1000 Genomes Project (1KG) panel using Japanese whole genome sequencing (WGS) data, with sample sizes ranging from 1 K to 7 K individuals enrolled through the Biobank Japan (BBJ) project, and sequencing depths ranging from 3× to 30×. Among these panels, an augmented reference panel comprising 7472 WGS samples of mixed depth (1KG+7K) exhibit the greatest improvement in imputation quality relative to the Trans-Omics for Precision Medicine (TOPMed) reference panel.

Retraction of "Feprazone Prevents Free Fatty Acid (FFA)-Induced Endothelial Inflammation by Mitigating the Activation of the TLR4/MyD88/NF-κB Pathway".

[This retracts the article DOI: 10.1021/acsomega.0c05826.

The effect of ultraviolet-C on the senescence of bitter gourd fruit and the key factors analyzed by transcriptomic and metabolomic analyses.

Bitter gourd (Momordica charantia L.) is a tropical and subtropical vegetable that is popular for its rich nutritional content. However, its immature fruit has a short shelf life and spoils easily.

Time-resolved MR fingerprinting for T* signal extraction: MR fingerprinting meets echo planar time-resolved imaging.

Purpose: This study leverages the echo planar time-resolved imaging (EPTI) concept in MR fingerprinting (MRF) framework for a new time-resolved MRF (TRMRF) approach, and explores its capability for fast simultaneous quantification of multiple MR parameters including T, T, T*, proton density, off resonance, and B .

Methods: The proposed TRMRF method uses the concept of EPTI to track the signal change along the EPI echo train for T* weighting with a k-t Poisson-based sampling order designed for acquisition. A two-dimensional decomposition algorithm was designed for the image reconstruction, enabling fast and precise subspace modeling.

Insights and implications for transcriptomic analysis of heat stress-induced intestinal inflammation in pigs.

Background: Heat stress (HS) can affect the physiology and metabolism of animals. HS-induced intestinal inflammation in pigs is a common disease, causing severe diarrhea, that can result in substantial economic losses to the pig industry, but the molecular mechanisms and pathogenicity of this disease are not fully understood. The objective of this study was to identify the differentially expressed genes (DEGs) and long noncoding RNAs (DELs) related to inflammation in the colon tissues of pigs under constant (1, 7, and 14 days) HS.

Human acellular amniotic membrane/polycaprolactone vascular grafts prepared by electrospinning enable vascular remodeling in vivo.

Background: Vascular transplantation is an effective treatment for severe vascular lesions. The design of the bioactive and mechanical properties of small-caliber vascular grafts is critical for their application in tissue engineering. In this study, we sought to develope a small-caliber vascular graft by electrospinning a mixture of a human acellular amniotic membrane (HAAM) and polycaprolactone (PCL).

Development of a pharmacokinetic/pharmacodynamic evaluation model for osteomyelitis and usefulness of tedizolid as an alternative to vancomycin against MRSA osteomyelitis.

Objectives: This study aimed to develop a suitable osteomyelitis model for pharmacokinetic/pharmacodynamic (PK/PD) evaluation and to investigate the target PK/PD values of vancomycin and tedizolid against methicillin-resistant Staphylococcus aureus (MRSA) osteomyelitis.

Methods: An osteomyelitis model was established by implanting an MRSA-exposed sterilized suture in the tibia of normal mice and mice with cyclophosphamide-induced neutropenia. The suitability of the osteomyelitis mouse model for PK/PD evaluation was assessed using vancomycin as an indicator.

Circulating CD45RAFoxp3 Treg cells serve as a biomarker for predicting minimal clinical manifestations status of myasthenia gravis.

Aims: Regulatory T cells (Tregs) are key mediators of the induction of immune tolerance; however, the mechanisms by which they regulate myasthenia gravis (MG) are not fully understood. This study aimed to explore the characteristics of Tregs and their subpopulations in the peripheral blood of patients with minimal clinical manifestations (MM) of MG and identify biomarkers that predict MM-MG for treatment guidance.

Materials And Methods: The clinical data of patients with general MG who visited our hospital were retrospectively analyzed.

R150S mutation in the human oxytocin receptor: Gain-of-function effects and implication in autism spectrum disorder.

This study investigates the rs547238576 (R150S) missense variant in the oxytocin receptor (OXTR) gene, previously observed through screening of rare variants in Japanese individuals with autism spectrum disorders (ASD). Contrary to the anticipated loss-of-function, R150S exhibits gain-of-function effects, enhancing oxytocin (OXT) sensitivity, ligand-binding affinity, and OXT-induced Ca mobilization in vitro. This suggests R150S may alter OXT signaling, potentially contributing to the excitatory/inhibitory imbalance seen in ASD and other psychiatric disorders.

Initial Experience of Metabolic Imaging with Hyperpolarized [1-C]pyruvate MRI in Kidney Transplant Patients.

Background: Kidney transplant is the treatment of choice for patients with end-stage renal disease. Early detection of allograft injury is important to delay or prevent irreversible damage.

Purpose: To investigate the feasibility of hyperpolarized (HP) [1-C]pyruvate MRI for assessing kidney allograft metabolism.