Publications by authors named "Xiaoxi Lin"
Purpose: Acute kidney injury (AKI) secondary to Rhabdomyolysis syndrome represents a life-threatening complication, characterized by notably high incidence and mortality rates. The role of cellular senescence in the progression of AKI has increasingly garnered attention in recent years. Our previous research has demonstrated that remote ischemic postconditioning (RIPC) can attenuate renal cellular senescence and elevation of serum level of interleukin-6 (IL-6) induced by ischemia-reperfusion injury following crush injury.
View Article and Find Full Text PDFBackground: Despite ongoing advancements in medical aesthetics, there remains a lack of consensus regarding a standardized postoperative care protocol following laser treatment for skin pigmentation disorders.
Objectives: To evaluate the influence of postoperative facial cleansing practices on the efficacy and safety of laser therapy among patients diagnosed with pigmentary skin diseases.
Methods: Thirty patients diagnosed with pigmented lesions (freckles and/or solar lentigines) were randomly allocated to two distinct groups.
Background: Both nonablative fractional (NAFL) laser combined with intense pulsed light (IPL) and picosecond alexandrite laser (PSAL) with diffractive lens array (DLA) have been documented for their efficacy in facial rejuvenation.
Objective: To observe the safety and efficacy of PSAL-DLA and IPL-NAFL in the rejuvenation of Chinese individuals.
Methods: Each subject (n = 18) received three treatments on half of their face, with 1-month interval between treatments.
The cellular uptake routes of peptides and proteins are complex and diverse, often handicapping therapeutic success. Understanding their mechanisms of internalization requires chemical derivatization with approaches that are compatible with wash-free and real-time imaging. In this work, we developed a new late-stage labeling strategy for unprotected peptides and proteins, which retains their biological activity while enabling live-cell imaging of uptake and intracellular trafficking.
View Article and Find Full Text PDFBackground: The application of randomized controlled trials (RCTs) outcomes of botulinum toxin type A (BoNT-A) to actual patient care faces a significant hurdle due to research waste (RW). This includes the results of RCTs that have not been published even 4 years after completion and those with insufficiently reported outcomes and design flaws. The prevalence of RW within BoNT-A-associated RCTs remains uncertain.
View Article and Find Full Text PDFPIK3CA-related overgrowth spectrum (PROS) encompasses several rare conditions that lead to overgrowth of various body parts resulting from activating variants in . The absence of ideal cell models significantly impedes progress in PROS research. In this study, we focused on facial infiltrating lipomatosis (FIL) (A disorder within PROS) and aimed to establish and characterize an immortalized PROS cell line.
View Article and Find Full Text PDFBackground: To identify the risk factors for bronchiectasis patients with active pulmonary tuberculosis (APTB) and to develop a predictive nomogram model for estimating the risk of APTB in bronchiectasis patients.
Methods: A retrospective cohort study was conducted on 16,750 bronchiectasis patients hospitalized at the Affiliated Hospital of Guangdong Medical University and the Second Affiliated Hospital of Guangdong Medical University between January 2019 and December 2023. The 390 patients with APTB were classified as the case group, while 818 patients were randomly sampled by computer at a 1:20 ratio from the 16,360 patients with other infections to serve as the control group.
Background: Lipopolysaccharide (LPS) triggers the activation of nuclear factor kappa B (NF-κB) by interacting with Toll-like receptor 4 (TLR4), leading to the production of various proinflammatory enzymes and cytokines that are crucial in the development of acute lung injury (ALI). Mitoxantrone (MTX) has been demonstrated to mitigate the inflammatory response caused by LPS; however, its precise function in the context of ALI is not fully comprehended.
Purpose: This study aimed to investigate the inhibitory effects and underlying mechanisms of MTX against LPS-induced ALI.
Article Synopsis
- Nevus of Ito and Mongolian spots are forms of patchy dermal melanocytosis that can look similar, making diagnosis tricky for doctors.
- The review highlights differences in their epidemiology, clinical features, and treatment options, noting that Mongolian spots usually fade with age while nevus of Ito can persist and turn malignant.
- Innovative treatments, such as lower-energy lasers, are becoming more effective, especially for children, indicating a promising shift in managing these skin conditions.
Background: A notable obstacle in applying the findings of hyaluronic acid (HA)-related randomised controlled trials (RCTs) to real-world patient treatment is trial waste (TW). To date, the extent of TW in RCTs for HA is not clear.
Objectives: To analyse the extents of TW within HA-RCTs and identify protective factors against TW.
Article Synopsis
- The study examines the effectiveness of different sizes of forehead tissue expanders in improving reconstructive outcomes and minimizing donor site deformities following surgery.
- It analyzed data from 79 patients who received either small (50/80 mL) or large (150/200 mL) expanders, finding no major demographic differences between the two groups.
- Results indicated that larger expanders led to less frontal deformation and better overall reconstruction results, suggesting that larger expanders are preferable for forehead procedures.
Article Synopsis
- * The researchers developed high-performance fluorescent biosensors called sensitive to arginine (STAR) that allow for real-time monitoring of arginine levels in cells, mice, and clinical samples.
- * Using STAR, they discovered the influence of different amino acids on arginine levels and found that serum arginine levels tend to rise with age, which could help in assessing the progression of conditions like vitiligo.
Article Synopsis
- Capillary malformation-arteriovenous malformation (CM-AVM) is a rare genetic disorder linked to mutations in the RASA1 and EPHB4 genes, characterized by abnormal blood vessel formations.
- This study focused on 59 East Asian patients to analyze the phenotypic characteristics of CM-AVM and explore the relationship between genetic variants and clinical manifestations.
- Results indicated that specific head and neck CM patterns are associated with RASA1 mutations, where a higher variant allele frequency (above 30%) increases the likelihood of multifocal CMs, highlighting the importance of genetic factors in understanding CM-AVM progression.
Unlabelled: A series of randomized controlled trials (RCTs) have advanced the therapeutic approaches for vascular anomalies (VA). However, a notable obstacle in applying the findings of these trials to real-world patient care is trial waste (TW). To date, the extent of TW in RCTs for VA is not clear.
View Article and Find Full Text PDFPosttranslational modifications (PTMs) of proteins play central roles in regulating the protein structure, interactome, and functions. A notable modification site is the aromatic side chain of Tyr, which undergoes modifications such as phosphorylation and nitration. Despite the biological and physiological importance of Tyr-PTMs, our current understanding of the mechanisms by which these modifications contribute to human health and disease remains incomplete.
View Article and Find Full Text PDFBackground: Atrophic acne scars (AAS) are disfiguring and permanent changes caused by inflammatory acne. Fractional carbon dioxide is a common ablative device used to treat this condition. However, issues such as unclear effectiveness, frequent treatments, and potential side effects exist.
View Article and Find Full Text PDFFacial infiltrating lipomatosis (FIL) is a congenital disorder. The pathogenesis of FIL is associated with mutations, but the underlying mechanisms remain undetermined. We found that the adipose tissue in FIL demonstrated adipocytes hypertrophy and increased lipid accumulation.
View Article and Find Full Text PDFBackground: Facial infiltrating lipomatosis is characterized by excessive growth of adipose tissue. Its etiology is associated with somatic phosphatidylinositol 3-kinase catalytic subunit alpha (PIK3CA) variants, but the specific mechanisms are not yet fully understood.
Methods: We collected facial adipose tissue from both FIL patients and non-FIL individuals, isolated the stromal vascular fraction (SVF) and performed single-cell transcriptome sequencing on these samples.
Purpose: To analyze the changes in the characteristics of randomized controlled trials (RCTs) in the field of scarring over the last two decades, unveil the components of research waste (RW) within these RCTs, and identify targets for improvement.
Methods: A search was conducted on ClinicalTrials.gov for RCTs registered from January 2000 to December 2023, using "scar" as the keyword.