Construction of a mitochondrial-targeting near-infrared fluorescent probe for detection of viscosity changes in type 2 diabetes mellitus and nonalcoholic steatohepatitis.

The intracellular viscosity plays a pivotal role as a physicochemical factor and an important indicator of organelles performance. Abnormal changes in subcellular viscosity are often associated with cellular malfunction and various diseases. Nonalcoholic steatohepatitis (NASH) is the most common liver disease related with type 2 diabetes mellitus (T2DM), and both are linked to aberrant mitochondrial viscosity.

Negative Regulation of RNF90 on RNA Virus-Triggered Antiviral Immune Responses Targeting MAVS.

The antiviral innate immunity is the first line of host defense against viral infection. Mitochondrial antiviral signaling protein (MAVS, also named Cardif/IPS-1/VISA) is a critical protein in RNA virus-induced antiviral signaling pathways. Our previous research suggested that E3 ubiquitin-protein ligases RING-finger protein (RNF90) negatively regulate cellular antiviral responses by targeting STING for degradation, though its role in RNA virus infection remains unknown.

Joint Raindrop and Haze Removal from a Single Image.

In a recent study, it was shown that, with adversarial training of an attentive generative network, it is possible to convert a raindrop degraded image into a relatively clean one. However, in real world, raindrop appearance is not only formed by individual raindrops, but also by the distant raindrops accumulation and the atmospheric veiling, namely haze. Current methods are limited in extracting accurate features from a raindrop degraded image with background scene, the blurred raindrop regions, and the haze.