(Rubiaceae), a new species from south-western China and northern Vietnam.

, a new species from south-western China and northern Vietnam, is described and illustrated. The new species is characterised by the glabrous surfaces on almost all plant parts, congested inflorescences and broad-ovate to ovate bracts 9-22 × 4-11 mm. It morphologically differs from the closest species, , mainly in most plant parts being glabrous, bracts broad-ovate to ovate, apex acute or sometimes obtuse, corollas inside with a ring of white hairs at the middle and anthers inserted near the middle in long-styled flowers.

Polyphyly of (Urticaceae) congruent with plastome structural variation.

is a taxonomically challenging group within the nettle family (Urticaceae). The polyphyly of the genus has been proposed by previous studies with respect to five genera (, , , , and ). Extensive homoplasy of morphological characters has made generic delimitation problematic.

Factors associated with antiretroviral treatment adherence among people living with HIV in Guangdong Province, China: a cross sectional analysis.

Background: Understanding factors associated with antiretroviral treatment (ART) adherence is crucial for ART success among people living with HIV (PLHIV) in the "test and treat" era. Multiple psychosocial factors tend to coexist and have a syndemic effect on ART adherence. We aimed to explore factors associated with ART adherence and the syndemic effect of multiple psychosocial factors on ART adherence among PLHIV newly starting ART in Guangdong Province, China.

-Glucosidase Inhibitory Phytochemical Components of Chinese Endemic Plant var. .

var. is an endemic plant in China. There have been no chemical or pharmacological studies of this plant reported before.

Chloramine Disinfection of Levofloxacin and Sulfaphenazole: Unraveling Novel Disinfection Byproducts and Elucidating Formation Mechanisms for an Enhanced Understanding of Water Treatment.

The unrestricted utilization of antibiotics poses a critical challenge to global public health and safety. Levofloxacin (LEV) and sulfaphenazole (SPN), widely employed broad-spectrum antimicrobials, are frequently detected at the terminal stage of water treatment, raising concerns regarding their potential conversion into detrimental disinfection byproducts (DBPs). However, current knowledge is deficient in identifying the potential DBPs and elucidating the precise transformation pathways and influencing factors during the chloramine disinfection process of these two antibiotics.

 (Loganiaceae), a new species from a karst region in Guangxi, China.

, a new species from Guangxi, China, is described and illustrated in this study. It is morphologically similar to because of the terete stems, creeping and branched at the base, the leaves which are pilose on both surfaces and the bilobed capsules with two erect horns. The new species can be distinguished from by its taller habit, up to 20-50 cm tall, its linear leaves, 4-18 × 0.

Suppression of PI3Kp110β Reduces Cell Viability and Induces Apoptosis in Human Esophageal Cancer.

Objective: Activation of PI3K pathway has been reported to promote survival, tumorigenicity and metastasis in the esophageal cancer (EC), and the PI3Kp110β (one of PI3K family) contributed to tumorigenesis in types of cancers. However, it is still unclear whether PI3Kp110β effects the progression of EC.

Methods: RT-qPCR and western blot were used to detect the expression of PI3Kp110β in the patients with EC and ECA-109 cells transfected with si-PI3Kp110β.

YTHDF2 interference suppresses the EMT of cervical cancer cells and enhances cisplatin chemosensitivity by regulating AXIN1.

M6A reader YTH structural domain family 2 (YTHDF2) has been recognized to play an oncogenic role in numerous tumors, but its role in cervical cancer has not been extensively discussed yet. This paper was designed to explore the role of YTHDF2 in cervical cancer and identify its underlying mechanism. The expression of YTHDF2 was first determined in cervical cancer cells by quantitative reverse-transcription polymerase chain reaction and western blot.

A new species of Music frog (Anura, Ranidae, ) from Mt Daming, Guangxi, China.

, a new music frog species, is proposed, based on a series of specimens collected from Mt Daming, Guangxi, southern China. The new species is close to , , , and from southwestern and south-central China and northern Indochina, while the relationships among these species remain unresolved. sp.

, gen. et sp. nov., the youngest ellimmichthyiform (clupeomorph) fish to date from the Oligocene of South China.

A new ellimmichthyiform, , gen. et sp. nov.

A new species of Leptobrachella (Anura: Megophryidae) from southern Guangxi, China.

This study describes a new member of the genus Leptobrachella, Leptobrachella shangsiensis sp. nov., based on morphological, acoustic and molecular analyses from southern Guangxi, China.

Apigenin Combined With Gefitinib Blocks Autophagy Flux and Induces Apoptotic Cell Death Through Inhibition of HIF-1α, c-Myc, p-EGFR, and Glucose Metabolism in EGFR L858R+T790M-Mutated H1975 Cells.

Cancer cells are characterized by abnormally increased glucose uptake and active bio-energy and biosynthesis to support the proliferation, metastasis, and drug resistant survival. We examined the therapeutic value of the combination of apigenin (a natural small-molecule inhibitor of Glut1 belonging to the flavonoid family) and gefitinib on epidermal growth factor receptor (EGFR)-resistant mutant non-small cell lung cancer, to notably damage glucose utilization and thus suppress cell growth and malignant behavior. Here, we demonstrate that apigenin combined with gefitinib inhibits multiple oncogenic drivers such as c-Myc, HIF-1α, and EGFR, reduces Gluts and MCT1 protein expression, and inactivates the 5' adenosine monophosphate-activated protein kinase (AMPK) signaling, which regulates glucose uptake and maintains energy metabolism, leading to impaired energy utilization in EGFR L858R-T790M-mutated H1975 lung cancer cells.

Rediscovery of Rhacophorus yaoshanensis and Theloderma kwangsiensis at their type localities after five decades.

Rhacophorus yaoshanensis Liu Hu, 1962 and Theloderma kwangsiensis Liu Hu, 1962 were described by Liu Hu (1962) based on two specimens and one specimen, respectively, from the Dayaoshan Ranges, Guangxi, China. Since these two species were described, no additional specimens have been collected from their type localities, presenting an issue for phylogenetic studies of the genera. Five decades later, we have rediscovered R.

[Population Status of Centropus sinensis in Guangxi Province].

Objective: T0 understand the population distribution, species abundance and habitats requirement of a medicinal animal, Centropus sinensis, in Guangxi Province.

Methods: Line transect methods were used to census population number and habitat types in 18 counties or cities of Guangxi.

Results: Centropus sinensis distributed in all study area, with a higher population density in the south than in the north.

Physical mapping of 32 genetic markers on the Pseudomonas aeruginosa PAO1 chromosome.

The Pseudomonas aeruginosa chromosome was fractionated with the enzymes SpeI and DpnI, and genomic fragments were separated by PFGE and used for mapping a collection of 40 genes. This permitted the localization of 8 genes previously mapped and of 32 genes which had not been mapped. We showed that a careful search of databases and identification of sequences that were homologous to known genes could be used to design and synthesize DNA probes for the mapping of P.