Purpose: To evaluate the efficacy and safety of oral ibrexafungerp (HS-10366) versus placebo in Chinese patients with vulvovaginal candidiasis (VVC).
Methods: A double-blind, placebo-controlled, randomized, multicenter phase III study was conducted in symptomatic VVC patients. Patients received (2:1) twice-daily oral ibrexafungerp 300 mg or matching placebo for 1 day.
Vulvovaginal candidiasis (VVC) is a common condition among women. Fluconazole remains the dominant treatment option for VVC. Oteseconazole is a highly selective inhibitor of fungal CYP51.
View Article and Find Full Text PDFFor an interferometric fiber-optic gyroscope (IFOG), the angle random walk, which represents the sensitivity of rotation detection, is mainly limited by the relative intensity noise (RIN) of a broadband source. Using a single-mode fiber ring resonator (SM-FRR) to filter the spectrum of a broadband light source is a common strategy for reducing the RIN at the proper IFOG frequency. However, this method depends on the polarization cross-coupling within the SM-FRR.
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