Publications by authors named "Xiaowan Li"

This study examined the effects of sodium bicarbonate (SC), curcumin (CC), and their combination (CC + SC) on the structural and gel properties of bovine myofibrillar proteins (MPs) under oxidative conditions. The results demonstrated that the addition of CC and SC significantly reduced carbonyl formation associated with protein oxidation (P < 0.05), with the combination of CC + SC showing the strongest inhibitory effect.

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Background: Heart failure (HF) patients admitted to the intensive care unit (ICU) often face high short-term mortality rates. This study aims to investigate the relationship between lactate dehydrogenase (LDH) levels and all-cause mortality in critically ill patients with HF.

Methods: Data from the MIMIC-IV database were extracted for subjects eligible for HF diagnosis.

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  • BTLA is an inhibitory immune checkpoint that interacts with HVEM to regulate immune balance and maintain immune tolerance on the same cell, while also affecting different immune cells to suppress immune responses.
  • Dysregulation of the BTLA/HVEM interaction can lead to impaired immune cell function, allowing tumor cells to evade immune detection and progress.
  • Research indicates that BTLA and HVEM are often abnormally expressed in various tumors, making them potential targets for future immunotherapy approaches in treating hematologic malignancies.
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Background: Rice, a staple food for over half of the global population, exhibits significant diversity in grain shape characteristics, which impact not only appearance and milling quality but also grain weight and yield. Identifying genes and loci underlying these traits is crucial for improving rice breeding programs. Previous studies have identified multiple quantitative trait loci (QTLs) and genes regulating grain length, width, and length-width ratio; however, further investigation is necessary to elucidate their regulatory pathways and their practical application in crop improvement.

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Esophageal cancer (EC) is the sixth leading cause of cancer-related deaths, and its treatment poses significant challenges. In recent years, photodynamic, photothermal, and chemodynamic therapies have emerged as alternative strategies for tumor intervention. However, limitations such as poor tumor targeting, insufficient microenvironment responsiveness, and unclear mechanisms hinder their application.

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Background: Although serum bicarbonate is a reliable predictor of various disease complications, its relationship with postoperative delirium (POD) remains unclear. Our research aimed to assess the effect of baseline serum bicarbonate levels on the incidence of POD in cardiac surgery patients.

Methods: A retrospective analysis was conducted on cardiac surgery patients who met specific inclusion and exclusion criteria, using data from the Marketplace for Information in Critical Care Medicine (MIMIC-IV) database.

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Background: Cervical cancer remains the second most common cause of death in women and poses a growing public health challenge. It is urgent to increase cervical cancer screening rates in Kenya as per the 2018 Kenya National Cancer Screening Guidelines. Addressing access to care may serve as a target to achieve this goal; however, how individual dimensions of access to care are associated with the utilization of cervical cancer screening services in low- and middle-income countries, including Kenya, remains unclear.

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Aims: Examining the connection between the triglyceride-glucose (TyG) index and chronic kidney disease (CKD) was the aim of this investigation.

Methods: Data from the National Health and Nutrition Examination Survey (NHANES) covering the years 1999-2020 were analyzed in this study. The TyG index was calculated as Ln (triglycerides (mg/dl) * fasting glucose (mg/dl)/2).

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Article Synopsis
  • Multi-drug resistant bacteria are a major concern for antibiotic treatment, and LysECD7, an endolysin from phages, shows potential as a treatment option.
  • The researchers genetically fused LysECD7 with specific peptides to enhance its effectiveness, leading to the selection of the fusion protein Lys-Li5-MSI for further improvement.
  • Modifications to the selected fusion protein, including the addition of a fatty acid, resulted in an improved pharmacokinetic profile and greater therapeutic success in treating infections in mice.
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Visual information is important for accurate spatial coding and memory-guided navigation. As a crucial area for spatial cognition, the medial entorhinal cortex (MEC) harbors diverse spatially tuned cells and functions as the major gateway relaying sensory inputs to the hippocampus containing place cells. However, how visual information enters the MEC has not been fully understood.

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  • The study investigates the relationship between monocyte-to-lymphocyte ratio (MLR) and prostate cancer (PCa), finding a positive correlation, which suggests that higher MLR may indicate a higher risk of PCa.
  • Data from the National Health and Nutrition Examination Survey (NHANES) was analyzed, with results showing that MLR has a strong ability to predict PCa compared to other inflammatory biomarkers.
  • The conclusion emphasizes that elevated MLR levels in American adults could signal a greater risk for developing prostate cancer, highlighting the potential importance of monitoring this inflammatory marker.
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Disorder of complement response is a significant pathogenic factor causing some autoimmune and inflammation diseases. The Complement Inhibitor (OmCI), a small 17 kDa natural protein, was initially extracted from soft tick salivary glands. The protein was found binding to complement C5 specifically, inhibiting the activation of the complement pathway, which is a successful therapeutic basis of complement-mediated diseases.

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  • - The study aimed to investigate the relationship between the systemic inflammation response index (SIRI) and chronic kidney disease (CKD) using data from the National Health and Nutrition Examination Survey (NHANES) spanning 1999 to 2020.
  • - Findings revealed a positive correlation between SIRI and CKD, with SIRI levels increasing the likelihood of low estimated glomerular filtration rate (eGFR) and albuminuria, suggesting SIRI could be a strong indicator of kidney health issues.
  • - The research concluded that SIRI outperformed other inflammatory biomarkers in predicting CKD, albuminuria, and low-eGFR, suggesting its potential utility in clinical assessment.
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  • - Two-dimensional (2D) materials like ReS are effective for enhancing Raman spectroscopy (SERS) through interactions that improve signal strength from probe molecules.
  • - A new method involving dynamic coulomb repulsion is proposed, allowing for better electronic interaction by creating an uneven distribution of hot electrons when the ReS/graphene heterostructure is excited by a laser.
  • - Using R6G as a probe, this technique enhances detection limits to 10 M and achieves a signal enhancement factor of 2.15 × 10, while also demonstrating uniformity, stability, and unique properties that could apply to other 2D heterostructures for better SERS performance.
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Aims: This investigation examined the possibility of a relationship between neutrophil-to-lymphocyte ratio (NLR) and diabetic kidney disease (DKD) in type 2 diabetes mellitus (T2DM) patients.

Methods: Adults with T2DM who were included in the National Health and Nutrition Examination Survey (NHANES) between 1999 and 2020 were the subjects of the current cross-sectional investigation. Low estimated glomerular filtration rate (eGFR) (< 60 mL/min/1.

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Background: The psychological state of patients with post stroke limb movement disorders undergoes a series of changes that affect rehabilitation training and recovery of limb motor function.

Aim: To determine the correlation between motor rehabilitation and the psychological state of patients with limb movement disorders after stroke.

Methods: Eighty patients with upper and lower limb dysfunction post stroke were retrospectively enrolled in our study.

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Aims: We aimed to investigate the potential association between weight-adjusted-waist index (WWI) and chronic kidney disease (CKD).

Design And Methods: This research examined data collected from the National Health and Nutrition Examination Survey (NHANES) spanning from 1999 to 2020. CKD was defined as the low estimated glomerular filtration rate (eGFR) or the existence of albuminuria (urinary albumin-to-creatinine ratio (ACR) ≥ 30mg/g).

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Ultrasound has been widely used for physical modifications of starch because of its effectiveness and environment friendliness; however, only a few reports have focused on the effect of varying ultrasonic treatments on the physicochemical properties of potato flour. In the present study, ultrasound at varying power levels (200, 300, 400, 500, and 600 W) and time intervals (20, 40, 60, 80, and 100 min) were used to obtain sonicated flour. Sonicated potato flour exhibited a significant (P < 0.

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Mitochondrial viscosity is a critical factor affecting numerous physiological processes, including phagocytosis. Abnormal viscosity in mitochondria is related to some pathological activities and diseases. Evaluating and detecting the changes in mitochondrial viscosity in vivo is crucial.

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Alzheimer's disease (AD) and Parkinson's disease (PD) are the most common neurodegenerative diseases (NDDs) threatening the lives of millions of people worldwide, including especially elderly people. Currently, due to the lack of a timely diagnosis and proper intervention strategy, AD and PD largely remain incurable. Innovative diagnosis and therapy are highly desired.

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  • This study investigates Layer 1 interneurons (L1INs) in the medial entorhinal cortex (MEC) to understand their role in brain function, as their microcircuitry is not well understood.
  • Researchers identified three distinct types of L1INs, each with unique morphological and electrical characteristics, and discovered different connectivity patterns compared to the neocortex.
  • The study also highlights a dorsoventral gradient in L1IN microcircuits, where specific cells show varied input and inhibitory effects on principal neurons, helping to clarify the function of L1INs in the MEC.
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Quinones are potential pollutants and redox active compounds widely distributed in environmental media. In this study, methyl-p-benzoquinone (MBQ) was introduced into Fe(III)/peroxydisulfate system (Fe(III)/PDS) to expedite the conversion of Fe(III) to Fe(II) and the degradation of atrazine (ATZ), ultimately establishing an environmentally friendly system of "treating pollution with pollution". MBQ/Fe(III)/PDS system showed superior performance to traditional Fe(II)/PDS system in pH range of 2-7.

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In this study, natural pyrite (NP) was used to activate peroxydisulfate (PDS) for imidacloprid (IMD) degradation. NP was characterized by X-ray diffraction (XRD), X-ray fluorescence spectrometry (XRF), scanning electron microscopy (SEM), transmission electron microscopy (TEM) and X-ray photoelectron spectroscopy (XPS). Effects of key reaction parameters (NP dosage, PDS concentration and initial pH) and co-existing ions on IMD degradation in the NP/PDS system were investigated.

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  • Adhesion G protein-coupled receptors (aGPCRs) play crucial roles in various physiological functions and present promising targets for disease treatment, yet their activation mechanisms are not fully understood.* -
  • The study focuses on the cryo-electron microscopy structures of GPR110, an aGPCR, revealing unique ligand engagement models and activation conformations, as well as insights into how G-proteins interact with the receptor.* -
  • Key findings highlight differences in how different G-proteins engage with GPR110, offering a clearer understanding of the activation process through the removal of an inhibitory domain and the role of a stalk peptide.*
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Four new daphnane-type diterpenes named tianchaterpenes C-F (-) and six known ones were isolated from . Their structures were elucidated based on chemical and spectral analyses. The comparisons of calculated and experimental electronic circular dichroism (ECD) methods were used to determine the absolute configurations of new compounds.

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