Publications by authors named "Xiaotong Xing"

A series of organic-inorganic composite geopolymer paste samples were prepared with slag-based geopolymer and three types of hydrophilic organic polymers, i.e., PVA, PAA, and CPAM, by ordinary molding and pressure-mixing processes.

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Controllable self-assembly of the DNA-linked gold nanoparticle (AuNP) architecture for biomedical applications remains a key challenge. Here, we describe the use of the programmed DNA tetrahedral structure to control the assembly of three different types of AuNPs (∼20, 10, and 5 nm) by organizing them into defined positioning and arrangement. A DNA-assembled "core-satellite" architecture is built by DNA sequencing where satellite AuNPs (10 and 5 nm) surround a central core AuNP (20 nm).

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Article Synopsis
  • - DNAzymes, discovered in 1994, are stable, easy to synthesize, and highly sensitive molecules used in biosensing and therapy, especially RNA-cleaving DNAzymes which act as reporters to transmit detectable signals.
  • - The review focuses on recent advancements in RNA-cleaving DNAzyme-based amplification strategies for enhanced biosensing, covering applications in diagnostics and disease treatment.
  • - Two main amplification strategies are detailed: direct response strategies using designed single-stranded DNAzymes, and combinational strategies involving complex methods like cascade reactions, CRISPR-Cas12a, and DNA walkers, along with a discussion of current challenges and future prospects.
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As a "star material", 2D transition metal carbides and/or nitrides (MXenes) have tremendous potential applications in biosensor development and molecular imaging. MXenes have a lot of advantages due to their large specific surface, excellent electrical conductivity, adjustable band gap, and easy modification. MXenes that immobilized with DNA strands, proteins, enzymes, or other bioluminescent materials on the surface, have been used to measure small molecules with extraordinary sensitivity and remarkable limit of detection.

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In this work, two series of chemically reactive polymers, silane coupling agents (SCAs) and water-soluble polymers, were specifically designed as an additive to improve the ductility of slag geopolymer paste by vibration pressure technique. The influences of organic polymers on the fluidity, rheological behavior, mechanical property, porosity, and toughening mechanism of slag geopolymer were investigated. The polycondensation and bonding characteristics of organic-inorganic products were calculated by H liquid nuclear magnetic resonance (NMR) technology and Fourier transform infrared (FT-IR).

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Aggregation-induced emission (AIE)-active luminogens (AIEgens) have demonstrated exciting potential for the application in cancer phototheranostics. However, simultaneously achieving tumor-activated bright emission, enhanced reactive oxygen species (ROS) generation, high tumor accumulation, and minimized ROS depletion remains challenging. Here, a metal-organic framework (MOF) hybrid AIEgen theranostic platform is designed, termed A-NUiO@DCDA@ZIF-Cu, composed of an AIEgen-loaded hydrophobic UiO-66 (A-NUiO@DCDA) core and a Cu-doped hydrophilic ZIF-8 (ZIF-Cu) shell.

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Objective: To observe the effect of acupuncture for regulating spleen and stomach on aspirin resistance in patients with type 2 diabetes mellitus (T2DM) and explore the effect mechanism.

Methods: A total of 68 T2DM patients complicated with aspirin resistance were randomized into an observation group and a control group, 34 cases in each one. On the base of the conventional treatment for diabetes, aspirin enteric-coated tablets were prescribed for oral administration, 100 mg each time, once daily in the control group.

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Static gains are often required for control, diagnosis and optimization of nonlinear dynamic systems. This paper proposes a new approach to estimate static gains for nonlinear dynamic systems from steady-state values hidden in historical data. First, steady-state values of system inputs and outputs are extracted by automatically finding data segments in steady-state conditions.

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Synopsis of recent research by authors named "Xiaotong Xing"

  • - Xiaotong Xing's research focuses on innovative applications of organic-inorganic composites, with a notable emphasis on enhancing mechanical properties of slag-based geopolymers and studying their interaction with various hydrophilic polymers in construction materials.
  • - In the biomedical field, Xing has explored the development of DNA assembly techniques for constructing plasmonic nanostructures, which can be applied for sensitive detection of microRNA and imaging in tumor studies, showcasing significant advancements in cancer diagnostics.
  • - Additionally, Xing has investigated RNA-cleaving DNAzymes as amplifiers in biosensing and therapeutic strategies, highlighting their stability and sensitivity for improving diagnostic and treatment methods in diverse healthcare applications.