Frequent and mild scrotal heat stress in mice epigenetically alters glucose metabolism in the male offspring.

Several studies have reported that health problems occur in assisted reproductive technology (ART)-conceived offspring. Recently, investigations have demonstrated that paternal environmental conditions influence offspring health. However, it is unclear whether the factors that cause male infertility per se affect offspring health and contribute to health problems in ART-born children.

sp. nov., isolated from the production water of a water-flooded oil reservoir in PR China.

A novel, moderately thermophilic, Gram-stain-negative bacterium, designated strain J18, was isolated from a water-flooded oil reservoir. Cells were aerobic, oxidase- and catalase-positive, with a polar flagellum. Growth occurred at 35-60 °C and at pH 6-8.

Regulation of Cathode-Electrolyte Interphase via Electrolyte Additives in Lithium Ion Batteries.

As the power supply of the prosperous new energy products, advanced lithium ion batteries (LIBs) are widely applied to portable energy equipment and large-scale energy storage systems. To broaden the applicable range, considerable endeavours have been devoted towards improving the energy and power density of LIBs. However, the side reaction caused by the close contact between the electrode (particularly the cathode) and the electrolyte leads to capacity decay and structural degradation, which is a tricky problem to be solved.

Prognosis evaluation of universal acute coronary syndrome: the interplay between SYNTAX score and ApoB/ApoA1.

Background: Acute coronary syndrome (ACS) is a group of clinical syndromes associated with substantial morbidity and mortality rate. SYNTAX and SYNTAX II score used to be a reference for surgical selection of coronary revascularization and prognosis evaluation in patients with 3-vessel or left main artery disease. In addition, apoB/apoA1 is an important predictor of ACS risk.

Characteristics and mechanism of anammox granular sludge with different granule size in high load and low rising velocity sewage treatment.

An integrated investigation to structural, activity and microbial diversity of anammox granular sludge (AnGS) in a wastewater treatment system with high ammonia nitrogen load was performed and aimed to establish the relationship between granular size and performance. With the increase in granule size, the main component of extracellular polymeric substances (EPS) changed from slime EPS to tightly-bound EPS, while the organic component remained the same, and the specific anammox activity increased. However, the results of qPCR and high-throughput sequencing showed that for granules with sizes inferior than 4.

A big data approach to improving the vehicle emission inventory in China.

Estimating truck emissions accurately would benefit atmospheric research and public health protection. Here, we developed a full-sample enumeration approach TrackATruck to bridge low-frequency but full-size vehicles driving big data to high-resolution emission inventories. Based on 19 billion trajectories, we show how big the emission difference could be using different approaches: 99% variation coefficients on regional total (including 31% emissions from non-local trucks), and ± as large as 15 times on individual counties.

[Effects of "Grain for Green" program and coal mining on sediment production in a typical small watershed of Yushenfu Mining Region, Northwest China].

Soil erosion in the ecologically fragile zone is severely affected by the intensified coal mining activities in the Yushenfu Mining Region of the Loess Plateau. Soil erosion controlling projects such as the "Grain for Green" program are continuously implemented by the government, which has effectively mitigated or even controlled soil erosion. Coal mining results in new environmental problems, which has changed the erosion characteristics and sediment transport in watersheds.

Calreticulin regulated intrinsic apoptosis through mitochondria-dependent and independent pathways mediated by ER stress in arsenite exposed HT-22 cells.

Arsenic is a naturally occurring environmental toxicant. Chronic exposure to arsenic is linked with neurological damage. Although the mechanisms remain to be elucidated, it is currently believed that neural cell apoptosis is one of the underlying mechanisms of arsenic-induced neurotoxicity.

Low-temperature radiofrequency coblation reduces treatment interval and post-operative pain of laryngotracheal recurrent respiratory papillomatosis.

Laryngeal papillomatosis is a benign disease in the larynx but with the potential to develop into significant complications as a result of its high recurrence rate. CO2 laser and radiofrequency controlled ablation (coblation) have been used to treat recurrent respiratory papillomatosis, but detailed comparisons of their respective treatment outcomes are not fully investigated. This retrospective study examines the procedure time, time interval between interventions, blood loss during operation, post-operative complications and pain scores among patients who received either CO2 laser or radiofrequency coblation interventions for laryngotracheal recurrent respiratory papillomatosis.

Malignant melanotic Xp11 neoplasms exhibit a clinicopathologic spectrum and gene expression profiling akin to alveolar soft part sarcoma: a proposal for reclassification.

The classification of the distinct group of mesenchymal neoplasms, first described as 'Xp11 translocation perivascular epithelioid cell tumor (PEComa)' and for which the term 'melanotic Xp11 neoplasm' or 'Xp11 neoplasm with melanocytic differentiation' has recently been proposed, remains challenging and controversial. We collected 27 melanotic Xp11 neoplasms, the largest series to date, for a comprehensive evaluation. Fourteen of the cases, together with eight alveolar soft part sarcomas (ASPS), nine conventional PEComas and a control group of seven normal tissues were submitted to RNA sequencing.

Mitochondrial genomes of three Bostrichiformia species and phylogenetic analysis of Polyphaga (Insecta, Coleoptera).

Here we determined mitogenomes of three Bostrichiformia species. These data were combined with 51 previously sequenced Polyphaga mitogenomes to explore the higher-level relationships within Polyphaga by using four different mitogenomic datasets and three tree inference approaches. Among Polyphaga mitogenomes we observed heterogeneity in nucleotide composition and evolutionary rates, which may have affected phylogenetic inferences across the different mitogenomic datasets.

Genetic Characterization of the O-Antigen and Development of a Molecular Serotyping Scheme for .

is a well-characterized opportunistic pathogen that is closely associated with various nosocomial infections. The O-antigen, which is one of the most variable constituents on the cell surface, has been used widely and traditionally for serological classification of many gram-negative bacteria. is divided into 30 serotypes, based on its O-antigen diversity.

Effect of Electroacupuncture and Counseling on Sub-Threshold Depression: A Study Protocol for a Multicenter Randomized Controlled Trial.

Background: Sub-threshold depression is common and could impair function, as well as increase the risk of developing major depression. Despite evidence of efficacy for electroacupuncture (EA) and counseling in the treatment of sub-threshold depression, the sample size is insufficient and the level of evidence remains low. This study aims to evaluate the effectiveness of sub-threshold depression treatments by comparing the treatment effects among EA, counseling, and combination therapy, as well as to further study their mechanism.

Heat Stress and Pulsed Unfocused Ultrasound: The Viability of these Physical Approaches for Drug Delivery into Testicular Seminiferous Tubules.

Aim: To investigate the application of Scrotal Heat Stress (SHS) and Pulsed Unfocused Ultrasound (PuFUS) to explore Blood-Testis Barrier (BTB) permeability in adult mice.

Background: The BTB provides a stable microenvironment and a unique immune barrier for spermatogenesis. Meanwhile, it blocks macromolecular substances access, including therapeutic agents and antibodies, thereby it decreases the therapeutic or immunocontraception effects.

Association of Genetic Variants With Moyamoya Disease in 13 000 Individuals: A Meta-Analysis.

Background and Purpose- A growing body of evidence indicates genetic components play critical roles in moyamoya disease (MMD). Firm conclusions from studies of this disease have been stymied by small sample sizes and a lack of replicative results. This meta-analysis was conducted to determine whether these genetic polymorphisms are associated with MMD.

gen. nov., sp. nov., a new member of the family isolated from oil reservoir water.

A novel Gram-staining-negative, spiral-shaped bacterium, designated strain 64-1, was isolated from oil reservoir water collected from Liaohe oilfield, north-eastern China. Growth occurred at 15-55 °C and pH 6.0-10.

Coupling Magnetic Single-Crystal Co Mo O with Ultrathin Nitrogen-Rich Carbon Layer for Oxygen Evolution Reaction.

Transition-metal oxides as electrocatalysts for the oxygen evolution reaction (OER) provide a promising route to face the energy and environmental crisis issues. Although palmeirite oxide A Mo O as OER catalyst has been explored, the correlation between its active sites (tetrahedral or octahedral) and OER performance has been elusive. Now, magnetic Co Mo O @NC-800 composed of highly crystallized Co Mo O nanosheets and ultrathin N-rich carbon layer is shown to be an efficient OER catalyst.

An UPLC-MS/MS Method for Simultaneous Determination of Tropicamide and Phenylephrine in Rabbit Ocular Tissues and Plasma.

Mixed eye drops containing 0.5% tropicamide and 0.5% phenylephrine are commercially available for cycloplegic refraction.

Nanostructures for Electrocatalytic CO Reduction.

One of the most effective ways to cope with the problems of global warming and the energy shortage crisis is to develop renewable and clean energy sources. To achieve a carbon-neutral energy cycle, advanced carbon sequestration technologies are urgently needed, but because CO is a thermodynamically stable molecule with the highest carbon valence state of +4, this process faces many challenges. In recent years, electrochemical CO reduction has become a promising approach to fix and convert CO into high-value-added fuels and chemical feedstock.

Quantum chemical calculations on the mechanism and kinetics of ozone-initiated removal of p-coumaryl alcohol in the atmosphere.

p-Coumaryl alcohol (p-CMA), as the simplest lignin precursor, was determined in the process of lignin polymer degradation and wood smoke. However, its transformation and migration in the atmosphere have not been well clarified. In this work, the gas-phase reaction mechanisms and kinetic parameters of ozone-initiated removal of p-CMA were performed by using quantum chemical calculations.

Molecular characterization and functional analysis of a Rel gene in the Pacific oyster.

The nuclear factor-κB (NF-κB) signaling pathway plays a crucial role in regulating many physiological processes such as development, inflammation, apoptosis, cell proliferation, differentiation and immune responses. And the NF-κB/Rel family members were considered as the most important transcription factors in the NF-κB signaling pathway. In this study, we cloned a Rel homolog gene (named as CgRel2) from the Pacific oyster, Crassostrea gigas.

Predictive factors associated with glycaemic response to exenatide in Chinese patients with type 2 diabetes mellitus.

What Is Known And Objective: Exenatide is widely used in the treatment of type 2 diabetes mellitus (T2DM) because of its established effect on lowering glucose and promotion of weight loss. However, therapeutic response to exenatide varies considerably among patients with T2DM. The purpose of this study was to determine which variables can predict the response to exenatide and to individualize specific therapies for patients with T2DM who need treatment with exenatide.

Photothermal hierarchical carbon nanotube/reduced graphene oxide microspherical aerogels with radially orientated microchannels for efficient cleanup of crude oil spills.

High viscosity and low fluidity of heavy crude oils usually hinder their rapid diffusion into porous adsorbents, causing a low efficiency of oil spill remediation. Photothermal effect is thus adopted to rapidly reduce the viscosity of heavy crude oil by in situ solar light heating. Photothermal carbon nanotube/reduced graphene oxide (CNT/RGO) microspherical aerogels are synthesized by fabrication of graphene oxide (GO)-based microspherical aerogels with numerous radially orientated microchannels, followed by growing CNTs inside the microchannels and high-temperature reduction of the GO components.

EGFR activation-induced decreases in claudin1 promote MUC5AC expression and exacerbate asthma in mice.

Claudin1 plays a critical role in maintaining the epithelial barrier, and mucus hypersecretion induced by epidermal growth factor receptor (EGFR) activation is a pivotal pathological feature of asthma. The relationship between claudin1 expression and mucus hypersecretion and EGFR activation is still poorly understood. In this report, we showed that claudin1 expression correlated with asthma stage, in both patients with asthma and in the house dust mite (HDM)-induced mouse asthma model.

A Case of 2019 Novel Coronavirus in a Pregnant Woman With Preterm Delivery.

We present a case of a 30-week pregnant woman with the 2019 novel coronavirus (COVID-19) delivering a healthy infant with no evidence of COVID-19.