A hybrid oxidation approach for converting high-strength urine ammonia into ammonium nitrate.

Nutrient resources contained in human urine have great potential to alleviate global agricultural fertilizer demand. Microbial nitrification is a recognized strategy for stabilizing urine ammonia into ammonium nitrate, a common fertilizer worldwide, but faces a core bottleneck of process instability due to microbial inhibition. This study reports a new approach by developing a hybrid oxidation process involving three stages-microbial ammonia oxidation, chemical nitrite oxidation and microbial nitrite oxidation.

Integrated urban wastewater management through on-site generation and application of ferrous carbonate.

Integrated urban water management is an increasingly popular concept that cost-effectively maximizes system-wide performance by holistically considering all aspects of water and wastewater sectors. An innovative technology enabling production of high-quality bioenergy and an iron salt, ferrous carbonate (FeCO), represents a significant opportunity for integrated urban water management. This study experimentally evaluates the effect of in-sewer FeCO dosing on the performance of sewers and the downstream wastewater treatment plants.

Bioplastic polyhydroxyalkanoate conversion in waste activated sludge.

Polyhydroxyalkanoates (PHA) have been proposed as a promising solution for plastic pollution due to their biodegradability and diverse applications. To promote PHA as a competitive commercial product, an attractive alternative is to produce and recover PHA in the use of mixed cultures such as waste activated sludge from wastewater treatment plants. PHA can accumulate in sludge with a potential range of 40%-65% g PHA/g VSS.

Multifaceted benefits of magnesium hydroxide dosing in sewer systems: Impacts on downstream wastewater treatment processes.

Magnesium hydroxide [Mg(OH)] is a non-hazardous chemical widely applied in sewer systems for managing odour and corrosion. Despite its proven effectiveness in mitigating these issues, the impacts of dosing Mg(OH) in sewers on downstream wastewater treatment plants have not been comprehensively investigated. Through a one-year operation of laboratory-scale urban wastewater systems, including sewer reactors, sequencing batch reactors, and anaerobic sludge digesters, the findings indicated that Mg(OH) dosing in sewer systems had multifaceted benefits on downstream treatment processes.

Integrated urban water management by coupling iron salt production and application with biogas upgrading.

Integrated urban water management is a well-accepted concept for managing urban water. It requires efficient and integrated technological solutions that enable system-wide gains via a whole-of-system approach. Here, we create a solid link between the manufacturing of an iron salt, its application in an urban water system, and high-quality bioenergy recovery from wastewater.

A critical review of chemical uses in urban sewer systems.

Chemical dosing is the most used strategy for sulfide and methane abatement in urban sewer systems. Although conventional physicochemical methods, such as sulfide oxidation (e.g.

Human fetal mesenchymal stem cells secretome promotes scarless diabetic wound healing through heat-shock protein family.

The high mortality rate of patients with diabetic foot ulcers is urging the appearance of an effective biomedical drug. Senescence is one of the major reasons of aging-induced decline in the diabetic wound. Our previous studies have demonstrated the anti-senescence effect of secretomes derived from human fetal mesenchymal stem cells (hfMSC).

UBE2O ubiquitinates PTRF/CAVIN1 and inhibits the secretion of exosome-related PTRF/CAVIN1.

Background: Exosomes are small vesicles released by cells, which have crucial functions in intercellular communication. Exosomes originated from cell membrane invagination and are released followed by multivesicular bodies (MVBs) fused with the cell membrane. It is known that Polymerase I and Transcript Release Factor (PTRF, also known as Caveolin-associated Protein-1, CAVIN1) plays an important role in caveolae formation and exosome secretion.

Impact of reactive iron in coal mine dust on oxidant generation and epithelial lung cell viability.

Coal workers' pneumoconiosis (CWP) is a preventable occupational lung disease caused by the chronic inhalation of coal mine dust. The inhalation of coal mine dusts can result in the development of a range of lung diseases termed coal mine dust lung diseases, which is not limited to CWP and includes silicosis, bronchitis, emphysema and cancer. For decades, the presence of elemental Fe, C and Si has been proposed to be the causal factors underlying CWP.

Azoramide protects iPSC-derived dopaminergic neurons with PLA2G6 D331Y mutation through restoring ER function and CREB signaling.

The endoplasmic reticulum (ER)-stress-induced cascade events are implicated in Parkinson's disease (PD). The discovery of drug candidates to protect dopaminergic (DA) neurons from ER-stress-induced oxidative damage is important to resolve the pathological aspects of PD and modify its progress. In this study, we found that a recently identified unfolded protein response (UPR) modulator, azoramide, showed protective effects on patient induced pluripotent stem cells-derived midbrain DA neurons with the homozygous phospholipase A2 group 6 (PLA2G6) D331Y mutant.

Hydroxyurea Facilitates Manifestation of Disease Relevant Phenotypes in Patients-Derived IPSCs-Based Modeling of Late-Onset Parkinson's Disease.

Induced pluripotent stem cells (iPSCs)-derived dopaminergic neurons might be reset back to the fetal state due to reprogramming. Thus, it is a compelling challenge to reliably and efficiently induce disease phenotypes of iPSCs-derived dopaminergic neurons to model late-onset Parkinson's disease (PD). Here, we applied a small molecule, hydroxyurea (HU), to promote the manifestation of disease relevant phenotypes in iPSCs-based modeling of PD.

Protective effects of ten oligostilbenes from seeds on interleukin-1β-induced rabbit osteoarthritis chondrocytes.

Background: is an important traditional Chinese herb used to treat osteoarthritis (OA) and oligostilbenes are the main active ingredient of the seeds of . The monomer -resveratrol of this species was demonstrated to have chondroprotective effects as a lead compound for the treatment of osteoarthritis, but it has not been applied due to its low efficacy.

Methods: Oligostilbenes were isolated by chromatography and were identified by NMR and HPLC.

Establishment of a congenital tooth agenesis related gene MSX1 knockout human embryonic stem cell lines by CRISPR-Cas9 technology.

Human MSX1 gene is mapped to chromosome 4 and encodes a 303aa homeobox protein MSX1. MSX1 expression appears during early tooth development of vertebrate embryogenesis. Mutations in this protein are related to human tooth anomalie, cleft lip and palate and congenital ectodermal dysplasia syndrome.