Novel Dual PPAR δ/γ Partial Agonist Induces Hepatic Lipid Accumulation through Direct Binding and Inhibition of AKT1 Phosphorylation, Mediating CD36 Upregulation.

ZLY06 is a dual agonist of peroxisome proliferator-activated receptor (PPAR) δ/γ, showing potential therapeutic effects on metabolic syndrome. However, our research has revealed that ZLY06 exhibits hepatotoxicity in normal C57BL/6J mice, though the precise mechanism remains unclear. This study aims to investigate the manifestations and mechanisms of ZLY06-induced hepatotoxicity.

Highly active catalyst using zeolitic imidazolate framework derived nano-polyhedron for the electro-oxidation of l-cysteine and amperometric sensing.

Herein, N-doped porous carbon nano-polyhedron embedded with CoO (CoO-NPCN) was reported for the electro-catalytic oxidation and amperometric detection of l-cysteine. CoO-NPCN was synthesized by the two-step redox calcination of zeolitic imidazolate framework (ZIF). Surface morphology characterization revealed that CoO-NPCN displayed a uniform size and rhombic dodecahedral shape.

Lattice Engineering on Metal Cocatalysts for Enhanced Photocatalytic Reduction of CO into CH.

Photocatalytic conversion of CO into CH represents an appealing approach to alleviate the world's continued reliance on fossil fuels and global warming resulting from increasing CO concentrations in the atmosphere. However, its practical application is greatly limited by serious electron-hole recombination in the photocatalysts and the production of CO and H as side reactions. Herein, for the first time, it is demonstrated that the photocatalytic reduction of CO to CH can be significantly improved through the simultaneous alloying and hydriding of metal cocatalysts.