miR-205 Regulates Tamoxifen Resistance by Targeting Estrogen Receptor Coactivator MED1 in Human Breast Cancer.

: Estrogen receptor-α coactivator MED1 is overexpressed in 40-60% of human breast cancers, and its high expression correlates with poor disease-free survival of patients undergoing anti-estrogen therapy. However, the molecular mechanism underlying MED1 upregulation and activation in breast cancer treatment resistance remains elusive. : miRNA and mRNA expression analysis was performed using the NCBI GEO database.

Upregulation of PD-L1 contributes to improving the apoptosis of granulosa cells via the PI3K/AKT pathway in PCOS.

Purpose: Polycystic ovary syndrome (PCOS) is a leading cause of anovulatory infertility and closely correlated with apoptosis in ovarian granulosa cells (GCs). Programmed cell death protein-1/programmed cell death ligand-1 (PD-1/PD-L1) pathway plays an important role throughout gestation and the pathogenesis of adverse pregnancy outcomes, but its mechanism in PCOS remains unclear.

Methods: The RNA sequencing data for PCOS patients were downloaded from the Gene Expression Omnibus (GEO) databases.

Heterologous Expression of Type II PKS Gene Cluster Leads to Diversified Angucyclines in J1074.

Heterologous expression has emerged as an effective strategy in activating cryptic gene clusters or improving yield. Eight compounds were successfully obtained by heterologous expression of the type II PKS gene cluster derived from marine sp. HDN155000 in the chassis host J1074.

MOF-derived three-dimensional porous dodecahedral structured bimetallic Mn/Co-C-N composite for high-performance durable oxygen reduction reaction electrocatalysts.

Investigating high-efficiency oxygen reduction reaction (ORR) catalysts is one of the most effective methods for addressing the sluggish kinetics at the fuel cell cathode. Bimetallic three-dimensional porous materials have garnered significant attention due to their diverse structures, large specific surface area and synergistic catalytic effects. Herein, we synthesized a bimetallic three-dimensional porous dodecahedral structure, Mn/Co-C-N, derived from MOF using a straightforward approach.

Circular RNA TAF4B targeting MFN2 accelerates cell growth in bladder cancer through p27 depression and AKT activation.

Introduction: Bladder cancer (BCa) is a common malignancy in the urinary tract. It has high recurrence rates and often requires microscopic examination, which presents significant challenges in clinical treatment. Previous research has shown that circular TAF4B (circTAF4B) is significantly upregulated in BCa and is associated with a poor prognosis.

Development of a standardized and reproducible murine femoral distraction osteogenesis model.

Objective: Distraction osteogenesis (DO) has been widely used to treat bone defects as its effectiveness in bone regeneration. Currently, distraction devices for establishing DO models are mainly developed for rats or large animals. However, a mouse DO model is in great need for in-depth mechanistic investigations using various transgenic mice.

Selective Copolymerization from Mixed Monomers of Phthalic Anhydride, Propylene Oxide and Lactide Using Nano-Sized Zinc Glutarate.

Selective polymerization with heterogeneous catalysts from mixed monomers remains a challenge in polymer synthesis. Herein, we describe that nano-sized zinc glutarate (ZnGA) can serve as a catalyst for the selective copolymerization of phthalic anhydride (PA), propylene oxide (PO) and lactide (LA). It was found that the ring-opening copolymerization (ROCOP) of PA with PO occurs firstly in the multicomponent polymerization.

Soliton and lump and travelling wave solutions of the (3 + 1) dimensional KPB like equation with analysis of chaotic behaviors.

Nonlinear evolution equations (NLEEs) have a wide range of applications in various fields, including physics, engineering, biology, economics, and more. These equations are used to describe complex systems that change over time, where the state or behavior of the system not only depends on the current situation, but may also be related to the past. A deep understanding of the solutions to NLEEs is of great significance for predicting and controlling the behavior of complex systems.

Arsenic(III) sequestration by terrestrial-derived soil protein: Roles of redox-active moieties and Fe(III).

Glomalin-related soil protein (GRSP) has demonstrated significant potential for water purification and remediation of heavy metals in soils; however, its redox reactivity for As(III) sequestration and the corresponding redox-active component are still poorly understood. This study investigated the photochemical properties of GRSP and its mechanism of oxidation/adsorption of As(III). The results showed that UV irradiation triggered electron transfer and the production of reactive oxygen species (ROS) in GRSP, thereby facilitating As(III) oxidation with promotion rates ranging from 43.

Amphibians rise to flourishing under climate change on the Qinghai-Tibetan Plateau.

Amphibian populations are declining globally due to climate change. However, the impacts on the geographic distribution of amphibians on the Qinghai-Tibetan Plateau (QTP), a global biodiversity hotspot with 112 species of amphibians that is sensitive to global climate change, remains unclear. In this study, MaxEnt and barycentre shift analyses were performed to reveal the impact of climate change on the potential future habitats of amphibians on the QTP using the BCC-CSM2-MR global climate model of the Coupled Model Intercomparison Projects Phase 6 (CMIP6) climate pattern with three shared socioeconomic pathways (SSP).

Augmenting osteoporotic bone regeneration through a hydrogel-based rejuvenating microenvironment.

Osteoporotic bone defects pose a significant challenge for bone regeneration as they exhibit impaired healing capacity and delayed healing period. To address this issue, this study introduces a hydrogel that creates a rejuvenating microenvironment, thereby facilitating efficient bone repair during the initial two weeks following bone defect surgery. The hydrogel, named GelHFS, was created through host-guest polymerization of gelatin and acrylated β-cyclodextrin.

Magnetically Powered Microrobotic Swarm for Integrated Mechanical/Photothermal/Photodynamic Thrombolysis.

Current thrombolytic drugs exhibit suboptimal therapeutic outcomes and potential bleeding risks due to their limited circulation time, inadequate thrombus penetration, and off-target biodistribution. Herein, a photosensitizer-loaded, red cell membrane-encapsuled multiple magnetic nanoparticles aggregate is successfully developed for integrated mechanical/photothermal/photodynamic thrombolysis. Red cell membrane coating endows magnetic particles with prolonged blood circulation and superior biocompatibility.

Distribution and ultrastructural characteristics of enteric glial cell in the chicken cecum.

Enteric glial cell (EGC) is involved in neuroimmune regulation within the enteric nervous system (ENS); however, limited information exists on the distribution and ultrastructure of EGC in the poultry gut. We aim to investigate the morphological features and distribution of EGC in the chicken cecum. Here, we investigated the distribution and ultrastructural features of chicken cecum EGC using immunohistochemistry (IHC) and transmission electron microscopy (TEM).

Exosomal Src from hypoxic vascular smooth muscle cells exacerbates ischemic brain injury by promoting M1 microglial polarization.

Inflammatory response mediated by M1 microglia is a crucial factor leading to the exacerbation of brain injury after ischemic stroke (IS). Under the stimulation of IS, vascular smooth muscle cells (VSMCs) switch to the synthetic phenotype characterized by exosome secretion. Previous studies have shown that exosomes play an important role in the regulation of microglial polarization.

Carrier effects of face mask-derived microplastics on metal ions: Enhanced adsorption by photoaging combined with biofilms, exemplified with Pb(Ⅱ).

Face masks have emerged as a significant source of microplastics (MPs) under the influence of biotic and abiotic interactions. However, the combined effects of abiotic photoaging and biofilm-loading on mask-derived MPs as carriers of metal ions are not clear. We investigated the Pb(Ⅱ) adsorption onto polypropylene (PP) and polyurethane (PU) mask-derived MPs treated by photoaging, biofilm-loading, and both combinations, evaluating the composite risks.

Base-resolution mC profiling across the mammalian transcriptome by bisulfite-free enzyme-assisted chemical labeling approach.

5-methylcytosine (mC) is a prevalent RNA modification crucial for gene expression regulation. However, accurate and sensitive mC sites identification remains challenging due to severe RNA degradation and reduced sequence complexity during bisulfite sequencing (BS-seq). Here, we report mC-TAC-seq, a bisulfite-free approach combining TET-assisted mC-to-fC oxidation with selective chemical labeling, therefore enabling direct base-resolution mC detection through pre-enrichment and C-to-T transitions at mC sites.

β-Mangostin targets and suppresses glioma via STING activation and tumor-associated microglia polarization.

Glioma, a common and highly malignant central nervous system tumor, markedly influences patient prognosis via interactions with glioma-associated macrophages. Previous research has revealed the anticancer potential of β-mangostin, a xanthone derivative obtained from the mangosteen fruit. This research investigated the role of β-mangostin on microglia in the glioma microenvironment and evaluated the efficacy of β-mangostin combined with anti-PD-1 antibody (αPD-1) in glioma-bearing mice.

Targeting SUMOylation with an injectable nanocomposite hydrogel to optimize radiofrequency ablation therapy for hepatocellular carcinoma.

Background: Incomplete radiofrequency ablation (iRFA) in hepatocellular carcinoma (HCC) often leads to local recurrence and distant metastasis of the residual tumor. This is closely linked to the development of a tumor immunosuppressive environment (TIME). In this study, underlying mechanisms and potential therapeutic targets involved in the formation of TIME in residual tumors following iRFA were explored.