Ephs in cancer progression: complexity and context-dependent nature in signaling, angiogenesis and immunity.

Eph receptors constitute the largest family of receptor tyrosine kinases, comprising 14 distinct members classified into two subgroups: EphAs and EphBs.. Despite their essential functions in normal physiological processes, accumulating evidence suggests that the involvement of the Eph family in cancer is characterized by a dual and often contradictory nature.

A Real-Time and Robust Neural Network Model for Low-Measurement-Rate Compressed-Sensing Image Reconstruction.

Compressed sensing (CS) is a popular data compression theory for many computer vision tasks, but the high reconstruction complexity for images prevents it from being used in many real-world applications. Existing end-to-end learning methods achieved real time sensing but lack theory guarantee for robust reconstruction results. This paper proposes a neural network called RootsNet, which integrates the CS mechanism into the network to prevent error propagation.

EphB1 promotes the differentiation and maturation of dendritic cells in non-small cell lung cancer.

EphB1 is implicated in numerous physiological and pathological processes, including nervous system diseases, cardiovascular diseases and cancers. It binds to membrane-bound ligands and drives bidirectional signaling. EphB1, along with its ligand ehrinB, plays a pivotal role in activating immune cells.

Brain-like position measurement method based on improved optical flow algorithm.

In this paper, a brain-like navigation scheme based on fuzzy kernel C-means (FKCM) clustering assisted pyramid Lucas Kanade (LK) optical flow algorithm is developed to measure the position of vehicle. The Speed Cell and Place Cell in animals' brain are introduced to construct the brain-like navigation mechanism which involves the optical flow method and image template matching to imitate the cells above-mentioned separately. To eliminate the singular values during optical flow calculation, the output of pyramid LK algorithm is clustered by FKCM algorithm firstly.

Increasing the antioxidant capacity of ceria nanoparticles with catechol-grafted poly(ethylene glycol).

Ceria nanoparticles are remarkable antioxidants due to their large cerium(III) content and the possibility of recovering cerium(III) from cerium(IV) after reaction. Here we increase the cerium(III) content of colloidally stable nanoparticles (, nanocrystals) using a reactive polymeric surface coating. Catechol-grafted poly(ethylene glycols) (PEG) polymers of varying lengths and architectures yield materials that are non-aggregating in a variety of aqueous media.

Efficient Near-Field Radiofrequency Imaging of Impact Damage on CFRP Materials with Learning-Based Compressed Sensing.

Carbon fiber-reinforced polymer (CFRP) is a widely-used composite material that is vulnerable to impact damage. Light impact damages destroy the inner structure but barely show obvious change on the surface. As a non-contact and high-resolution method to detect subsurface and inner defect, near-field radiofrequency imaging (NRI) suffers from high imaging times.

An Anti-Turbulence Self-Alignment Method for SINS under Unknown Latitude Conditions.

For the alignment problem of strapdown inertial navigation system (SINS) under the complex environment of unknown latitude, angular oscillation interference, and line interference, the ant colony simulated annealing algorithm of gravity vector optimization is proposed to obtain the gravity apparent motion vector optimization equation, and the polynomial fitting method is proposed to simultaneously perform latitude estimation and self-alignment in combination with the alignment principle of SINS. Simulations and experiments show that the proposed method has more robust anti-interference capability than the traditional interference-based alignment method, the latitude estimation accuracy is improved by six times, the self-alignment yaw angle error RMSE value after obtaining the latitude is within 0.7°, and the roll angle and pitch angle error values are within 0.

A D-2-hydroxyglutarate biosensor based on specific transcriptional regulator DhdR.

D-2-Hydroxyglutarate (D-2-HG) is a metabolite involved in many physiological metabolic processes. When D-2-HG is aberrantly accumulated due to mutations in isocitrate dehydrogenase or D-2-HG dehydrogenase, it functions in a pro-oncogenic manner and is thus considered a therapeutic target and biomarker in many cancers. In this study, DhdR from Achromobacter denitrificans NBRC 15125 is identified as an allosteric transcriptional factor that negatively regulates D-2-HG dehydrogenase expression and responds to the presence of D-2-HG.

An interaction-modeling mechanism for context-dependent Text-to-SQL translation based on heterogeneous graph aggregation.

For the context-dependent Text-to-SQL task, the generation of SQL query is placed in a multi-turn interaction scenario. Each turn of Text-to-SQL must take historical interactive information and database schema into account. Accordingly, how to encode and integrate these different types of texts (the question sentence, the corresponding SQL query, and database schema) is a tough problem.

Comparison of complications and visual outcomes between big-bubble deep anterior lamellar keratoplasty and penetrating keratoplasty for fungal keratitis.

Background: To compare the postoperative complications and visual outcomes of big-bubble deep anterior lamellar keratoplasty (BB-DALK) and penetrating keratoplasty (PK) for fungal keratitis (FK).

Methods: This retrospective study included 94 cases of BB-DALK for FK and 161 cases of PK for FK from a tertiary ophthalmology care centre.

Results: The most common FK pathogens were Fusarium (n = 84, 32.

2D Gadolinium Oxide Nanoplates as T Magnetic Resonance Imaging Contrast Agents.

Millions of people a year receive magnetic resonance imaging (MRI) contrast agents for the diagnosis of conditions as diverse as fatty liver disease and cancer. Gadolinium chelates, which provide preferred T contrast, are the current standard but face an uncertain future due to increasing concerns about their nephrogenic toxicity as well as poor performance in high-field MRI scanners. Gadolinium-containing nanocrystals are interesting alternatives as they bypass the kidneys and can offer the possibility of both intracellular accumulation and active targeting.

Unambiguous measurement range and error tolerance in dual-wavelength interferometry.

In dual or multiwavelength interferometry, the traditional equivalent wavelength method is widely used for phase recovery to enlarge the unambiguous measurement range (UMR). In fact, however, this method ignores information of size and sign (positive or negative) of single wavelength wrapped phases, and the extension of the UMR is not sufficient. For the reflective measurement, the largest UMR of the dual or multiwavelength interferometry is half of the least-common multiple (LCM) of single wavelengths, called the LCM effective wavelength, which is often several times the equivalent wavelength.

Libraries of Uniform Magnetic Multicore Nanoparticles with Tunable Dimensions for Biomedical and Photonic Applications.

Multicore iron oxide nanoparticles, also known as colloidal nanocrystal clusters, are magnetic materials with diverse applications in biomedicine and photonics. Here, we examine how both of their characteristic dimensional features, the primary particle and sub-micron colloid diameters, influence their magnetic properties and performance in two different applications. The characterization of these basic size-dependent properties is enabled by a synthetic strategy that provides independent control over both the primary nanocrystal and cluster dimensions.

Metabolic Engineering of for Production of Acetoin.

Acetoin is a potential platform compound for a variety of chemicals. MW3, a thermophilic and generally regarded as safe (GRAS) microorganism, can produce 2,3-butanediol with a high concentration, yield, and productivity. In this study, MW3 was metabolic engineered for acetoin production.

Combination of iterated cubature Kalman filter and neural networks for GPS/INS during GPS outages.

To improve the performance of the Global Positioning System/Inertial Navigation System (GPS/INS) integrated navigation system, current research studies merely combine neural networks with nonlinear filter methods. Few studies focus on how to optimize the parameters of the neural network and how to further improve the small error accumulated into the next filter step due to the imprecise design of the filter when setting the initial parameters in the GPS/INS integrated system. In this article, a dual optimization method consisting of an iterated cubature Kalman filter-Feedforward Neural Network (ICKF-FNN) and a radial basis function-cubature Kalman filter (RBF-CKF) is proposed to compensate the position and velocity errors of the integrated system during GPS outages.

A rapid measurement method for structured surface in white light interferometry.

White light interferometry (WLI) is an effective and widely-used technique for structured surface measurement. However, it requires multiframe interferograms with vertical scanning to realise large-scale measurement, which is time consuming and computationally intensive. This paper proposes a rapid surface measurement method to realise surface recovery with a single interferogram by white light interferometry.

Regulation of Glutarate Catabolism by GntR Family Regulator CsiR and LysR Family Regulator GcdR in Pseudomonas putida KT2440.

Glutarate, a metabolic intermediate in the catabolism of several amino acids and aromatic compounds, can be catabolized through both the glutarate hydroxylation pathway and the glutaryl-coenzyme A (glutaryl-CoA) dehydrogenation pathway in KT2440. The elucidation of the regulatory mechanism could greatly aid in the design of biotechnological alternatives for glutarate production. In this study, it was found that a GntR family protein, CsiR, and a LysR family protein, GcdR, regulate the catabolism of glutarate by repressing the transcription of and , two key genes in the glutarate hydroxylation pathway, and by activating the transcription of and , two key genes in the glutaryl-CoA dehydrogenation pathway, respectively.

Attitude measurement based on imaging ray tracking model and orthographic projection with iteration algorithm.

In the field of vision-based attitude estimation, camera model and attitude solving algorithm are the key technologies, which determine the measurement accuracy, effectiveness and applicability. Aiming at this issue, in this paper we probe into the generic imaging model and then develop a corresponding generic camera calibration method using two auxiliary calibration planes. The camera model is named as imaging ray tracking model.

Determine turntable coordinate system considering its non-orthogonality.

In industrial measurement and laboratory research, many measured objects are placed on the three-axis turntable. In this paper, we propose a fast and practical method to determine the turntable coordinate system with the aid of spatial coordinate of point cloud data. By sphere fitting, plane fitting, and point projection, the scattered point cloud data are combined together to obtain initial direction vectors.

Correction of errors due to uneven intensity distribution and inaccurate phase shifts in prism-based simultaneous phase-shifting interferometry.

Simultaneous phase-shifting interferometry (SPSI) is a suitable technique for dynamic surface measurement due to its rapid measurement capability. Based on whether there are obvious multiple phase-shifting channels in the setup, it can be divided into the multi-channel type and the pixelated phase-mask type. For the former type, two important error sources are the uneven intensity distribution among different phase-shifting channels and inaccurate phase shifts in each phase-shifting channel.

Attitude calculation method based on full-sky atmospheric polarization mode.

In the natural world, insects such as bees and sand ants can navigate with the aid of polarized skylight. Inspired by this, bio-inspired navigation systems based on polarized skylight have attracted considerable attention recently. As an important navigation parameter, attitude information is critical for control and navigation of a vehicle.

Seamless global positioning system/inertial navigation system navigation method based on square-root cubature Kalman filter and random forest regression.

In this paper, a seamless navigation dual-model based on Square-Root Cubature Kalman Filter (SRCKF) and Random Forest Regression (RFR) is developed to enhance the performance of the Global Positioning System (GPS)/Inertial Navigation System (INS) integrated navigation system. By using the proposed method, the system can ensure seamless navigation ability even during GPS signal outages. In the proposed dual-model, sub-model 1 that directly relates the specific force of INS to the measurement of filter and sub-model 2 that directly relates the cubature points and innovation of SRCKF to the error caused by filter are established.

d-2-Hydroxyglutarate dehydrogenase plays a dual role in l-serine biosynthesis and d-malate utilization in the bacterium .

is a very large bacterial genus in which several species can use d-malate for growth. However, the enzymes that can metabolize d-malate, such as d-malate dehydrogenase, appear to be absent in most species. d-3-Phosphoglycerate dehydrogenase (SerA) can catalyze the production of d-2-hydroxyglutarate (d-2-HG) from 2-ketoglutarate to support d-3-phosphoglycerate dehydrogenation, which is the initial reaction in bacterial l-serine biosynthesis.

Expression of PERK-eIF2α-ATF4 pathway signaling protein in the progression of hepatic fibrosis in rats.

Objective: This study aims to observe changes in the expression of the hepatic endoplasmic reticulum stress PERK-eIF2α-ATF4 signaling pathway protein in the progression of CCl-induced hepatic fibrosis in rats.

Methods: Male Wistar rats were sacrificed at the end of the 2, 4, 8 and 12 weeks, respectively. A specific test was performed to compare the pathological changes of hepatic tissues in the model and normal groups.

Increased glutarate production by blocking the glutaryl-CoA dehydrogenation pathway and a catabolic pathway involving L-2-hydroxyglutarate.

Glutarate is a five carbon platform chemical produced during the catabolism of L-lysine. It is known that it can be catabolized through the glutaryl-CoA dehydrogenation pathway. Here, we discover that Pseudomonas putida KT2440 has an additional glutarate catabolic pathway involving L-2-hydroxyglutarate (L-2-HG), an abnormal metabolite produced from 2-ketoglutarate (2-KG).