Publications by authors named "Xiaoting Du"

Chronic hepatitis B (CHB) remains a significant health challenge worldwide. The current treatments for CHB achieve less than 10% cure rates, majority of the patients are on therapy for life. Therefore, cure of CHB is a high unmet medical need.

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In general, image restoration involves mapping from low-quality images to their high-quality counterparts. Such optimal mapping is usually nonlinear and learnable by machine learning. Recently, deep convolutional neural networks have proven promising for such learning processing.

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Replication of the positive-strand RNA viruses generates double-stranded RNAs (dsRNAs) that are recognized by host pattern recognition receptors (PRRs) to trigger innate immune responses. Formation of the viral replication complex (RC) has been thought to shield dsRNA from being recognized by innate sensors. To elucidate the RC-mediated evasion of innate recognition, we selected poliovirus (PV) as a model.

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The cytoplasmic RNA sensors, retinoic acid-inducible gene I and melanoma differentiation-associated gene 5, play crucial roles in innate sensing of hepatitis C virus (HCV). However, the exact identity of the IFN inducer generated during HCV infection is poorly understood. To identify the IFN inducer, we extracted the RNAs from HCV-replicating cells and introduced these into IFN signalling-competent cells to examine IFN production.

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Unlabelled: Like almost all of the positive-strand RNA viruses, hepatitis C virus (HCV) induces host intracellular membrane modification to form the membrane-bound viral replication complex (RC), within which viral replicases amplify the viral RNA genome. Despite accumulated information about how HCV co-opts host factors for viral replication, our knowledge of the molecular mechanisms by which viral proteins hijack host factors for replicase assembly has only begun to emerge. Purification of the viral replicase and identification of the replicase-associated host factors to dissect their roles in RC biogenesis will shed light on the molecular mechanisms of RC assembly.

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Unlabelled: The cellular innate immune system recognizing pathogen infection is essential for host defense against viruses. In parallel, viruses have developed a variety of strategies to evade the innate immunity. The hepatitis B virus (HBV), a DNA virus that causes chronic hepatitis, has been shown to inhibit RNA helicase RIG-I-mediated interferon (IFN) induction.

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A novel method for rapid determination of eight lipophilic pesticides in vegetables was developed using dispersive liquid-liquid micro-extraction (DLLME) coupled with gas chromatography-tandem mass spectrometry (GC-MS/MS). The analyte in the vegetable was extracted with water-acetone (5 : 1, v/v) solution. Then, the extract was transferred into a centrifugal tube with 25 mg primary secondary amine (PSA), 50 mg C18 and 25 mg graphitized carbon black powder.

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Synopsis of recent research by authors named "Xiaoting Du"

  • - Xiaoting Du's research primarily focuses on viral infections, particularly hepatitis B and C, exploring mechanisms of viral replication and evasion of host immune responses, with an emphasis on novel therapeutic targets like GST-HG131 for chronic hepatitis B.
  • - In addition to viral research, Du contributes to advancements in image processing technologies, particularly through the development of a Cross-Scale Residual Network framework aimed at enhancing image super-resolution and restoring image quality using machine learning techniques.
  • - The author's work also includes methodological innovations in pesticide detection in agricultural products, showcasing a rapid extraction and analysis technique for lipophilic pesticide residues using novel liquid-liquid microextraction methods coupled with advanced chromatography.

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